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Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacologic Strategy toward Prevention of Metastases

  • Chapter
Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

Recent reports from several laboratories have emphasized the role of platelets in the development of certain tumor metastases (for review see 1). Platelets interact with certain tumor emboli, and in so doing, appear to enhance their survival in vivo. Both platelets as well as tumor cells adhere to subendothelial basement membrane. Platelets secrete permeability factors (2, 3) as well as tumor cell growth factors (4–7), which theoretically should assist in tumor cell penetration of the vessel wall and development of extravascular secondary tumor colonies.

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Authors
  1. Simon Karpatkin
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  2. Edward Pearlstein
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Karpatkin, S., Pearlstein, E. (1984). Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacologic Strategy toward Prevention of Metastases. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_11

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

  • eBook Packages: Springer Book Archive

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