Skip to main content
SpringerLink
Log in

Data Analysis from Michaelis-Menten Kinetics: Ins and Outs

  • Chapter
Kinetic Data Analysis

Abstract

One can observe Michaelian kinetics in the case when the enzyme does not follow Michaelis-Menten mechanism and one can determine deviations from Michaelis-Menten kinetics with an enzyme that follows Michaelian mechanism. The discrepancies between the measured kinetics and real mechanism may be due to the existence of isoenzymes, the non-identical behaviour of subunits in oligomeric enzymes, the association-dissociation of oligomers, the instability of the enzyme under assay conditions, the effect of ligands, interaction with proteins, other macromolecules or membrances, etc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Michaelis, L. and Menten, M.L. (1913), Biochem. Z. 49, 333 - 369.

    CAS  Google Scholar 

  2. Lineweaver, H. and Burk, D. (1934) J. Amer. Chem. Soc. 56, 658 - 666.

    Article  CAS  Google Scholar 

  3. Eadie, G.S. (1942) J. Biol. Chem. 146, 85 - 93.

    CAS  Google Scholar 

  4. Hofstee, B.J.H. (1952) Science, 116, 329 - 331.

    Article  CAS  Google Scholar 

  5. Hanes, C.S. (1932) Biochem. J. 26, 1406 - 1421.

    CAS  Google Scholar 

  6. Eisenthal, R. and Cornish-Bowden, A. (1974) Biochem. J. 139, 715 - 720.

    CAS  Google Scholar 

  7. De Miguel Merino, F. (1974) Biochem. J. 143, 93 - 95.

    Google Scholar 

  8. Fajszi, Cs. and Endrênyi, L. (1974) FEBS Lett. 4£, 240-246.

    Google Scholar 

  9. Briggs, G.E. and Haidane, J.B.S. (1925) Biochem. J. 19, 338- 339.

    Google Scholar 

  10. van Slyke, D.D. and Cullen, G.E. (1914) J. Biol. Chem. 19, 141 - 180.

    Google Scholar 

  11. Walter, C. (1965) “Steady State Applications in Enzyme Kinetics”, Ronald Press, New York.

    Google Scholar 

  12. Gutfreund, H. (1972) “Enzymes: Physical Principles”, Wiley- Interscience, London.

    Google Scholar 

  13. Walter, C. (1974) J. Theor. Biol. 44, 1 - 5.

    Article  CAS  Google Scholar 

  14. Walter, C. and Morales, M. (1964) J. Biol. Chem. 239, 1277 - 1283.

    CAS  Google Scholar 

  15. Wong, J.T.F. (1965) J. Amer. Chem. Soc. 87, 1788 - 1793.

    Article  CAS  Google Scholar 

  16. Walter, C. (1966) J. Theor. Biol. 15, 1 - 33.

    Article  Google Scholar 

  17. Heineken, F.G., Tsuchiya, H.M. and Aris, R. (1967) Math. Biosci. 95 - 113.

    Google Scholar 

  18. Heineken, F.G., Tsuchiya, H.M. and Aris, R. (1967) Math. Biosci. 1, 115 - 141.

    Article  Google Scholar 

  19. Otten, H.A. and Duysens, L.N.M. (1973) J. Theor. Biol. 39, 387 - 396.

    Article  CAS  Google Scholar 

  20. Otten, H.A. (1974) Math. Biosci, 19, 155 - 161.

    Article  Google Scholar 

  21. Bartha, F. (1980) J. Theor. Biol. 82, 141-147

    Google Scholar 

  22. Fischer, E. and Keleti, T. (1975) Acta Biochim. Biophys. Acad. Sei. Hung. 1JD, 221 - 227.

    Google Scholar 

  23. Webb, J.L. (1963) “Enzyme and Metabolie Inhibitors”, Vol. 1, Academic Press, New York.

    Google Scholar 

  24. Dixon, M. and Webb, E.C. (1964) “Enzymes”, 2nd ed., Longmans, London.

    Google Scholar 

  25. Gutfreund, H. (1965) “An Introduction to the Study of Enzymes”, Blackwell, Oxford.

    Google Scholar 

  26. Yakovlev, V.A. (1965) “Kinetika Fermentâtivnovo Kataliza”, Izd. Nauka, Moscow.

    Google Scholar 

  27. Walter, C. (1966) “Enzyme Kinetics”, Ronald Press, New York.

    Google Scholar 

  28. Laidler, K.J. (1968) “The Chemical Kinetics of Enzyme Action”,Clarendon Press, Oxford.

    Google Scholar 

  29. Reiner, J.M. (1969) “Behaviour of Enzyme Systems”, 2nd ed., 367 Van Nostrand-Reinhold, New York.

    Google Scholar 

  30. Dévényi, T., Elödi, P., Keleti, T. and Szabolcsi, G. (1969) “Strukturelle Grundlagen der biologischen Funktion der Proteine”, Akademiai Kiado, Budapest.

    Google Scholar 

  31. Plowman, K.M. (1972) “Enzyme Kinetics”, McGraw-Hill, New York.

    Google Scholar 

  32. Ricard, J . (1973) “Cinétique et mecanismes d’action desenzymes”, Doin, Paris.

    Google Scholar 

  33. Segel, I.H. (1975) “Enzyme Kinetics”, Wiley, New York-Sydney- London -Toron to.

    Google Scholar 

  34. Wong, J.T.F. (1975) “Kinetics of Enzyme Mechanisms”, Academic Press, London-New York-San Francisco.

    Google Scholar 

  35. Fromm, H.J. (1975) “Initial Rate Enzyme Kinetics”, Springer, New York-Heidelberg-Berlin.

    Book  Google Scholar 

  36. Cornish-Bowden, A. (1976) “Principles of Enzyme Kinetics”, Butterworths, London-Boston.

    Google Scholar 

  37. Berezin, I.V. and Klyosov, A.A. (1976) “Prakticheskiy Kurs Khimicheskoy i Fermentativnoy Kinetiki”, Izd. Moscow Univ., Moscow.

    Google Scholar 

  38. Keleti, T. (1976) “Az enzimkinetika alapjai”, 2nd ed., Tankönyvkiado, Budapest.

    Google Scholar 

  39. Ferdinand, W. (1976) “The Enzyme Molecule”, Wiley, London- New York-Sydney.

    Google Scholar 

  40. Engel, P. (1977) “Enzyme Kinetics”, Wiley, New York.

    Google Scholar 

  41. Levitzki,.A. (1978) “Quantitative Aspects of Allosteric Mechanisms”, Springer, Berlin-Heidelberg - New York.

    Book  Google Scholar 

  42. Kurganov, B.I. (1978) “Allostericheskie Fermenti”, Izd. Nauka, Moscow.

    Google Scholar 

  43. Cleland, W.W. (1963) Biochim. Biophys. Acta, 67, 104 - 137.

    Article  CAS  Google Scholar 

  44. Dalziel, K. (1957) Acta Chem. Scand. 11, 1706 - 1723.

    Article  CAS  Google Scholar 

  45. Dalziel, K. (1969) Biochem. J. 114, 547 - 556.

    CAS  Google Scholar 

  46. Fisher, J.R. and Hoagland, W.D., Jr. (1968) Adv. Biol. Med. Phys. 12, 163 - 211.

    CAS  Google Scholar 

  47. Peller, L. and Alberty, R.A. (1961) Progr. React. Kin. U 237 - 260.

    Google Scholar 

  48. Wong, J.T.F. and Hanes, C.S. (1962) Can. J. Biochem. Physiol. 40, 763-844.

    Google Scholar 

  49. Wong, J.T.F. and Hanes, C.S. (1969) Arch. Biochem. Biophys. 135, 50 - 59.

    Article  CAS  Google Scholar 

  50. Keleti, T., Ovâdi, J. and Batke, J. (1975/76) J. Mol. Catal. 1, 173 - 200.

    Google Scholar 

  51. Straub, F.B. and Szabolcsi, G. (1964) In “Molekularnaya Biologiya”, pp. 182 - 187, Izd. Nauka, Moscow.

    Google Scholar 

  52. Monod, J., Wyman, J. and Changeux, J.P. (1965) J. Mol. Biol. 12, 88 - 118.

    Article  CAS  Google Scholar 

  53. Koshland, D.E., Jr., Nemethy, G. and Filmer, D. (1966) Biochemistry, 5, 365 - 385.

    Article  CAS  Google Scholar 

  54. Citri, N. (1973) Adv. Enzymol. 37, 397 - 648.

    CAS  Google Scholar 

  55. Florini, J.R. and Vestling, C.S. (1957) Biochim. Biophys. Acta, 25, 575 - 578.

    Article  CAS  Google Scholar 

  56. Keleti, T. (1965) Acta Physiol Keleti, T. and Batke, J. (1965) Acta Physiol. Acad. Sci. Hung. 28, 195 - 207.

    CAS  Google Scholar 

  57. Keleti, T. (1965) Acta Physiol Keleti, T. and Batke, J. (1965) Acta Physiol. Acad. Sci. Hung. 28, 195 - 207.

    CAS  Google Scholar 

  58. Keleti, T. and Telegdi, M. (1966) Enzymologia, 31, 39 - 50.

    CAS  Google Scholar 

  59. Volkenstein, M.V. and Goldstein, N. (1966) Biochim. Biophys. Acta, 115, 478 - 485.

    Article  CAS  Google Scholar 

  60. Botts, D.J. and Morales, M. (1953) Trans. Faraday Soc. 49, 696 - 707.

    Article  CAS  Google Scholar 

  61. Hearon, J.Z., Bernhard, S.A., Friess, S.L., Botts, D.J. and Morales, M.F. (1959) In “The Enzymes” (P.D. Boyer, H. Lardy and K. Myrback,) Vol. 1, pp. 49 - 142, Adademic Press, New York.

    Google Scholar 

  62. Walter, C. (1962) Biochemistry, 652-658.

    Google Scholar 

  63. Frieden, C. (1964) J. Biol. Chem. 239, 3522 - 3531.

    CAS  Google Scholar 

  64. Keleti, T. (1968) Acta Biochim. Biophys. Acad. Sci. Hung. 3 247 - 258.

    CAS  Google Scholar 

  65. Cennamo, C. (1968) J. Theor. Biol. 21 _, 260 - 277.

    Google Scholar 

  66. Cennamo, C. (1969) J. Theor. Biol. Z3, 53-71.

    Google Scholar 

  67. Staub, M. and Denes, G. (1966) Biochim. Biophys. Acta, 128, 82 - 91.

    CAS  Google Scholar 

  68. Farago, A. and Denes, G. (1967) Biochim. Biophys. Acta, 136, 6 - 18.

    Article  CAS  Google Scholar 

  69. Keleti, T. (1967) J. Theor. Biol. 16, 337-355.

    Google Scholar 

  70. Fajszi, Cs. and Keleti, T. (1976) In “Mathematical Models of Metabolic Regulation” (T. Keleti and S. Lakatos, Eds.) Symp. Biol. Hung. Vol. 18, pp. 105–119, Akademiai Kiado, Budapest.

    CAS  Google Scholar 

  71. Keleti, T. (1975) In “Mechanism of Action and Regulation of Enzymes” (T. Keleti, ed.) Proc. 9th FEBS Meeting, Vol. 32, pp. 3 - 27, Akademiai Kiado, Budapest and North-Holland, Amsterdam.

    Google Scholar 

  72. Keleti, T. and Fajszi, Cs. (1971) Math. Biosci. 12_, 197 - 215.

    Google Scholar 

  73. Keleti, T. (1975) In “Physical Chemistry of Oscillatory Phenomena”, Faraday Symp. of Chem. Soc., Vol. 9, pp. 219 - 220, University Press, Aberdeen.

    Google Scholar 

  74. Ginsburg, A. and Stadtman, E.R. (1970) Ann. Rev. Biochem. 39, 429–472.

    Article  CAS  Google Scholar 

  75. Hess, B. and Boiteux, A. (1972) In “rotein-Protein Inter actions” (R. Jaenicke and E. Helmreich, Eds.) Proc. 23rd Mosbach Colloqu. pp. 271 - 297, Springer, Berlin-Heidelberg- New York.

    Google Scholar 

  76. Keleti, T., Batke, J., Ovadi, J., Jancsik, V. and Bartha, F. (1977) Adv. Enzyme Regul. 15, 233 - 265.

    Article  CAS  Google Scholar 

  77. Salerno, C., Ovadi, J., Churchich, J. and Fasella, P. (1975) In “Mechanism of Action and Regulation of Enzymes” (T. Keleti, ed.) Proc. 9th FEBS Meeting, Vol. 32, pp. 147- 160, Akademiai Kiado, Budapest and North-Holland, Amsterdam. Friedrich, P. (1974) Acta Biochim. Biophys. Acad. Sci. Hung. 9, 159-173.

    Google Scholar 

  78. Keleti, T., Batke, J., Ovadi, J., Jancsik, V. and Bartha, F. (1977) Adv. Enzyme Regul. 15, 233–265.

    Google Scholar 

  79. Ovádi, J. and Keleti, T. (1978) Eur. J. Biochem. SS_y 157 - 161.

    Google Scholar 

  80. Ovádi, J., Salerno, C., Keleti, T. and Fasella, P. (1978) Eur. J. Biochem. 90, 499 - 503.

    Article  Google Scholar 

  81. Patthy, L. and Vas, M. (1978) Nature, 276, 94-95.

    Google Scholar 

  82. Keleti, T. (1978) In “New Trends in the Description of the General Mechanism and Regulation of Enzymes” (S. Damjanovich, P. Elodi, and B. Somogyi, Eds.) Symp. Biol. Hung. Vol. 21, pp. 107 - 130, Akademiai Kiado, Budapest.

    Google Scholar 

  83. Friedrich, P., Apro-Kovacs, V.A. and Solti, M. (1977) FEBS Lett. 84, 183 - 186.

    Article  CAS  Google Scholar 

  84. Solti, M. and Friedrich, P. (1979) Eur. J. Biochem. 95, 551 - 559.

    Article  CAS  Google Scholar 

  85. Bartha, F. and Keleti, T. (1979) Oxid. Commun. 75 - 84.

    Google Scholar 

  86. Jancsik, V., Keleti, T., Biczok, Gy., Nagy, M., Szabo, Z. and Wolfram, E. (1975/76) J. Mol. Catal. 137-144.

    Google Scholar 

  87. Jancsik, Vv Keleti, T., Nagy, M., Fenyvesi, E., Bartha, A., Rudas, A., Kovacs, P. and Wolfram, E. (1979) J. Mol. Catal. 6, 41 - 49.

    Google Scholar 

  88. Katchalski, E., Silman, I. and Goldman, R. (1971) Adv. Enzymol. 34, 445 - 536.

    CAS  Google Scholar 

  89. Solti, M. and Friedrich, P. (1976) Mol. Cell. Biochem. 10, 145-152.

    Google Scholar 

  90. Linderstrtfm-Lang, K.U., Schellman, J.A. (1959) In “The Enzymes” (P.D. Boyer, H. Lardy and K. Myrbäck, Eds.) Vol. 1, 2nd ed., pp. 443 - 510, Academic Press, New York.

    Google Scholar 

  91. Schellman, J.A. and Schellman, C. (1964) In “The Proteins”, (H. Neurath, ed.) Vol. 2, 2nd ed., pp. 1 - 137, Academic Press, New York.

    Google Scholar 

  92. Hvidt, Aa. and Nielsen, S.O. (1966) Adv. Protein. Chem. 21, 287 - 386.

    Article  CAS  Google Scholar 

  93. Damjanovich, S. and Somogyi, B. (1978) In “New Trends in the Description of the General Mechanism and Regulation of Enzymes” (S. Damjanovich, P. Elödi and B. Somogyi, Eds.)Symp. Biol. Hung. Vol. 21, pp. 159 - 184, Akademiai Kiado, Budapest.

    Google Scholar 

  94. Závodszky, P., Abaturov, L.B. and Varshavskiy, J.H. (1966) Acta Biochim. Biophys. Acad. Sci. Hung. 389 - 402.

    Google Scholar 

  95. Bolotina, I.A., Markovich, D.S., Volkenstein, M.V. and Závodszky, P. (1967) Biochim. Biophys. Acta 132, 260 - 270.

    CAS  Google Scholar 

  96. Závodszky, P., Johansen, J.T. and Hvidt, Aa. (1975) Eur. J. Biochem. 56, 67 - 72.

    Article  Google Scholar 

  97. Venyaminov, S.Yu., Rajnavölgyi, E., Medgyesi, G.A., Gergely, J. and Zavodszky, P. (1976) Eur. J. Biochem. 67, 81 - 86.

    Article  CAS  Google Scholar 

  98. Jencks, W.P. (1966) In “Current Aspects of Biochemical Energetics” (N.O. Kaplan and E. Kennedy, Eds.) pp. 273 - 298, Academic Press, New York-London.

    Google Scholar 

  99. Damjanovich, S. and Somogyi, B. (1973) J. Theor. Biol. 41, 567 - 569.

    Article  CAS  Google Scholar 

  100. Careri, G. (1974) In “Quantum Statistical Mechanics in the Natural Sciences” (B. Kursunoglu, S.L. Mintz and S.M. Widmayer, Eds.) pp. 15 - 35, Plenum Press, New York.

    Google Scholar 

  101. Careri, G., Fasella, P. and Gratton, E. (1975) CRC Crit. Rev. Biochem. 3, 141-164. 370

    Google Scholar 

  102. Welch, G.R. (1977) Progr. Biophys. Molec. Biol. 32, 103 - 191.

    Article  CAS  Google Scholar 

  103. McCammon, J.A., Gelin, B.R. and Karplus, M. (1977) Nature, 267, 585 - 590.

    Article  CAS  Google Scholar 

  104. Wuthrich, K. and Wagner, G. (1978) Trends Biochem. Sei. 3 227 - 230.

    Article  Google Scholar 

  105. Karplus, M. and McCammon, J.A. (1979) Nature, 277, 578.

    Article  CAS  Google Scholar 

  106. Suezaki, Y. and Go, N. (1975) Int. J. Peptide Prot. Res. 7, 333 - 334.

    Article  CAS  Google Scholar 

  107. McCammon, J.A., Gelin, B.R., Karplus, M. and Wolynes, P.G. (1976) Nature, 262, 325-326.

    Google Scholar 

  108. Cooper, A. (1976) Proc. Nat. Acad. Sei. US, 73, 2740-2741.

    Google Scholar 

  109. Vas, M. and Boross, L. (1970) Acta Biochim. Biophys. Acad. Sei. Hung. 5, 203-213.

    Google Scholar 

  110. Vas, M. and Boross, L. (1974) Eur. J. Biochem. 43, 237 - 244.

    Article  CAS  Google Scholar 

  111. Vas, M. (1976) Acta Biochim. Biophys. Acad. Sei. Hung. 11, 105 - 112.

    CAS  Google Scholar 

  112. Telegdi, M. and Straub, F.B. (1973) Biochim. Biophys. Acta, 321, 210 - 219.

    CAS  Google Scholar 

  113. Vallee, B.L. and Riordan, J.F. (1978) In “Molecular Inter actions and Activity in Proteins”, Ciba Foundation Symposium 60, pp. 197 - 223, Exerpta Medica, Amsterdam-Oxford- New York.

    Google Scholar 

  114. Creighton, T.E. (1978) Progr. Biophys. Mol. Biol. 33, 231-297.

    Google Scholar 

  115. Brown, K.G., Erfurth, S.C., Small, E.W. and Peticolas, W.L. (1972) Proc. Nat. Acad. Sei. US, 69, 1467-1469.

    Google Scholar 

  116. Hull, W.E. and Sykes, B.D. (1975) J. Mol. Biol. 98,. 121 - 153.

    Google Scholar 

  117. Lakowicz, J.R. and Weber, G. (1973) Biochemistry, 12, 4171 - 4179

    Article  CAS  Google Scholar 

  118. Eftink, M.R. and Ghiron, C.A. (1976) Biochemistry, 15, 672 - 680.

    Article  CAS  Google Scholar 

  119. Ghose, R.C. and Englander, S.W. (1974) J. Biol. Chem. 249, 7950 - 7955.

    CAS  Google Scholar 

  120. Holowka, D.A. and Cathou, R.E. (1976) Biochemistry, 15, 3379- 3390.

    Google Scholar 

  121. Keleti, T. (1967) Acta Biochim. Biophys. Acad. Sei. Hung. 2, 31-37.

    Google Scholar 

  122. Frieden, C. (1970) J. Biol. Chem. 245, 5788 - 5799.

    Google Scholar 

  123. Frieden, C. (1979) Ann. Rev. Biochem. 48, 471 - 489.

    Article  CAS  Google Scholar 

  124. Ricard, J., Meunier, J.C. and Buc, J. (1974) Eur. J. Biochem. 49, 195 - 208.

    Google Scholar 

  125. Botts, D.J. (1958) Trans. Faraday Soc. S4, 593 - 604.

    Google Scholar 

  126. Fajszi, Cs. and Keleti, T. (1972) Biopolymers, 11, 119-126.

    Google Scholar 

  127. Ovädi, J., Telegdi, M., Batke, J. and Keleti, T. (1971) Eur. J. Biochem. 22_, 430 - 438.

    Google Scholar 

  128. Levitzki, A. (1974) J. Mol. Biol. 90, 451-458.

    Google Scholar 

  129. Markovich, D.S. and Krapivinsky, G.B. (1974) Mol. Biol. ( USSR ) 8, 857-863.

    Google Scholar 

  130. Osborn, H.H. and Hollaway, M.R. (1974) Biochem. J. 143, 651 - 662

    Google Scholar 

  131. Buhner, M., Ford, G.C., Moras, D., Olsen, K.W. and Rossmann, M.G. (1974) J. Mol. Biol. 82, 563 - 585.

    Article  Google Scholar 

  132. Buhner, M., Ford, G.C., Moras, D., Olsen, K.W. and Rossmann, M.G. (1974) J. Mol. Biol. 90, 25-49.

    Google Scholar 

  133. Batke, J., Keleti, T. and Fischer, E. (1974) Eur. J. Biochem. 46, 307 - 315.

    Google Scholar 

  134. Simon, I. (1972) Eur. J. Biochem. 30, 184 - 189.

    Article  CAS  Google Scholar 

  135. Batke, J. (1968) FEBS Lett. 2, 81 - 82.

    Article  CAS  Google Scholar 

  136. Malhotra, O.P. and Bernhard, S.A. (1968) J. Biol. Chem. 243, 1243 - 1252.

    CAS  Google Scholar 

  137. Seydoux, F., Malhotra, O.P. and Bernhard, S.A. (1974) CRC Crit. Rev. Biochem. 2_, 227 - 257.

    Google Scholar 

  138. Lazdunski, M., Peticlerc, C., Chappelet, D. and Lazdunski, C. (1971) Eur. J. Biochem. 20, 124 - 132.

    Article  CAS  Google Scholar 

  139. Lazdunski, M. (1972) Curr. Top. Cell. Regul. 6, 267-310.

    Google Scholar 

  140. Keleti, T. (1971) J. Theor. Biol. 3£, 545 - 551.

    Google Scholar 

  141. Fischer, E., Aranyi, P. and Keleti, T. (1973) Acta Biol. Med. Germ. 31, 153 - 174.

    CAS  Google Scholar 

  142. Batke, J. (1972) J. Theor. Biol. 3£, 313 - 324.

    Google Scholar 

  143. Ovádi, J., Batke, J., Bartha, F. and Keleti, T. (1979) Arch. Biochem. Biophys. 193, 28 - 33.

    Google Scholar 

  144. Kagan, Z.S., Dorozhko, A.I., Kovaleva, S.V. and Yakovleva, L.I. Biochim. Biophys. Acta, 403, 208 - 220.

    Google Scholar 

  145. Kurganov, B.I., Wenzel, K.W., Zimmermann, G., Yakovlev, V.A. and Hoffmann, E. (1975) Bioorg. Khim. ( USSR) U 632 - 645.

    Google Scholar 

  146. Kurganov, B.I. (1967) Mol. Biol. ( USSR ) 1, 17-27.

    Google Scholar 

  147. Nichol, L.W., Jackson, W.J.H. and Winzor, D.J. (1967) Biochemistry, 6», 2449-2456.

    Google Scholar 

  148. Frieden, C. (1967) J. Biol. Chem. 242, 4045 - 4052.

    CAS  Google Scholar 

  149. Kurganov, B.I. (1968) Mol. Biol. (USSR) 2_, 430 - 446.

    Google Scholar 

  150. Kurganov, B.I., Kagan, Z.S., Dorozhko, A.I. and Yakovlev, V.A. (1974) J. Theor. Biol. 47, 1-41.

    Google Scholar 

  151. Kurganov, B.I. (1975) In “Mechanism of Action and Regulation of Enzymes” (T. Keleti, Ed.) Proc. 9th FEBS Meeting, Vol. 32, pp. 29 - 42, Akademiai Kiado, Budapest and North- Holland, Amsterdam.

    Google Scholar 

  152. Kurganov, B.I. (1976) In “Mathematical Models of Metabolic Regulation”. (T. Keleti and S. Lakatos, Eds.) Symp. Biol. Hung. Vol. 18, pp. 31 - 45, Akademiai Kiado, Budapest.

    Google Scholar 

  153. Kurganov, B.I., Dorozhko, A.I., Kagan, Z.S. and Yakovlev, V.A. J. Theor. Biol. 60_, 271-286.

    Google Scholar 

  154. Kurganov, B.I., Dorozhko, A.I., Kagan, Z.S. and Yakovlev, V.A. (1976) J. Theor. Biol. 60, 287–299.

    Article  CAS  Google Scholar 

  155. Kurganov, B.I. (1977) J. Theor. Biol. 68, 521-543.

    Google Scholar 

  156. Phillips, A.T. (1974) CRC Crit. Rev. Biochem. 2_, 343 - 378.

    Google Scholar 

  157. Schonheyder, F. (1952) Biochem. J. 50, 378 - 384.

    CAS  Google Scholar 

  158. Schwert, G.W. (1969) J. Biol. Chem. 244, 1278 - 1284.

    CAS  Google Scholar 

  159. Klesov, A.A. and Berezin, I.V. (1972) Biokhimiya, 37, 170 - 183.

    CAS  Google Scholar 

  160. Bizzozero, S.A., Kaiser, A.W. and Dutter, H. (1973) Eur. J. Biochem. 33, 292 - 300.

    Article  CAS  Google Scholar 

  161. Atkins, G.L. and Nimmo, I.A. (1973) Biochem. J. 135, 779 - 784

    CAS  Google Scholar 

  162. Johansen, G. and Lumry, R. (1961) Compt. Rend. Trav. Lab. Carlsberg, 32, 185-214.

    Google Scholar 

  163. Wilkinson, G.N. (1961) Biochem. J. 80, 324 - 332.

    CAS  Google Scholar 

  164. Cleland, W.W . (1967) Adv. Enzymol. 29, 1–32.

    CAS  Google Scholar 

  165. Bates, D.J. and Frieden, C. (1973) J. Biol. Chem. 248, 7878- 7884.

    Google Scholar 

  166. Bates, D.J. and Frieden, C. (1973) J. Biol. Chem. 248, 7885- 7890.

    Google Scholar 

  167. Yun, S.-L. and Suelter, C.H. (1977) Biochim. Biophys. Acta, 480, 1 - 13.

    CAS  Google Scholar 

  168. Fernley, H.N. (1974) Eur. J. Biochem. 43, 377 - 378.

    Article  CAS  Google Scholar 

  169. Nimmo, I.A. and Atkins, G.L. (1974) Biochem. J. 141, 913 - 914.

    CAS  Google Scholar 

  170. Darvey, I.G., Shrager, R. and Kohn, L.D. (1975) J. Biol. Chem. 250, 4690 - 4701.

    Google Scholar 

  171. Halwachs, W. (1978) Biotechn. Bioeng. 20, 281 - 285.

    Google Scholar 

  172. Petersen, L.C. and Degn, H. (1978) Biochim. Biophys. Acta, 526, 85 - 92.

    CAS  Google Scholar 

  173. Duggleby, R.G. and Morrison, J.F. (1977) Biochim. Biophys. Acta, 48, 297 - 312.

    Google Scholar 

  174. Duggleby, R.G. and Morrison, J.F. (1978) Biochim. Biophys. Acta, 526, 398-409.

    Google Scholar 

  175. Chandler, J.P., Hill, D.E. and Spivey, H.O. (1972) Comput. Biomed. Res. 5, 515 - 534.

    Article  CAS  Google Scholar 

  176. London, J.W., Shaw, L.M. and Garfinkel, D. (1977) Anal. Chem. 49, 1716 - 1719.

    Article  CAS  Google Scholar 

  177. Hill, C.M. Waight, R.D. and Bardsley, W.G. (1977) Mol. Cell. Biochem. 15, 173 - 178.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Enzymology Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary

    T. Keleti

Authors
  1. T. Keleti
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Toronto, Toronto, Canada

    Laszlo Endrenyi

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Keleti, T. (1981). Data Analysis from Michaelis-Menten Kinetics: Ins and Outs. In: Endrenyi, L. (eds) Kinetic Data Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3255-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3255-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3257-2

  • Online ISBN: 978-1-4613-3255-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation