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Recent Studies on the Metabolism of 5’-Methylthioadenosine

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Natural Sulfur Compounds

Abstract

5’-Methylthioadenosine (MTA) represents one of the main products of S-adenosylmethionine (Ado-Met) metabolism and is distributed ubiquitously in micromolar amounts in several prokaryotes and eukaryotes1, 2. Although the chemical structure of this thioether was elucidated in 19243, its biological role as product of methionine metabolism was demonstrated by Schlenk in 19524, even before the discovery of its precursor Ado-Met5.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Second Chair, University of Naples First Medical School, Naples, Italy

    Vincenzo Zappia, Maria Cartenì-Farina, Giovanna Cacciapuoti & Adriana Oliva

  2. Laboratory for the Chemistry of Molecules of Biological Interest, C.N.R, Naples, Italy

    Agata Gambacorta

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  1. Vincenzo Zappia
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  2. Maria Cartenì-Farina
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  3. Giovanna Cacciapuoti
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  4. Adriana Oliva
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  5. Agata Gambacorta
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Editors and Affiliations

  1. University of Rome, Rome, Italy

    Doriano Cavallini

  2. Institute for Basic Research in Mental Retardation, Staten Island, New York, USA

    Gerald E. Gaull

  3. University of Naples, Naples, Italy

    Vincenzo Zappia

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Zappia, V., Cartenì-Farina, M., Cacciapuoti, G., Oliva, A., Gambacorta, A. (1980). Recent Studies on the Metabolism of 5’-Methylthioadenosine. In: Cavallini, D., Gaull, G.E., Zappia, V. (eds) Natural Sulfur Compounds. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3045-5_11

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  • DOI: https://doi.org/10.1007/978-1-4613-3045-5_11

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  • Print ISBN: 978-1-4613-3047-9

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