Skip to main content
SpringerLink
Log in

Glycoproteins of the Synapse

  • Chapter
Complex Carbohydrates of Nervous Tissue

Abstract

A consideration of the current state of our knowledge (or should I say ignorance) of the glycoproteins in CNS synapses is pivotal to an understanding of the function of the complex carbohydrates of nerve tissues. Just as snyapses fulfill the crucial role in the establishment, construction, reconstruction, and reinforcement of neuronal pathways of communication, so do glycoproteins subserve the task of establishing and maintaining contact among cells and provide a framework for information transfer at the molecular level. Thus, they may provide key structural and sensory elements not only in the maintenance of synaptic contacts but also in their establishment during synaptogenesis and in their possible modification as a result of experience.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Altman, J., 1972a, Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer, J. Comp. Neurol 145: 353–398.

    PubMed  CAS  Google Scholar 

  • Altman, J., 1972b, Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer, J. Comp. Neurol 145:399–464.

    CAS  Google Scholar 

  • Altman, J., 1972c, Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layer, J. Comp. Neurol 145: 465–514.

    PubMed  CAS  Google Scholar 

  • Banker, G., Crain, B., and Cotman, C. W., 1972, Molecular weights of the polypeptide chains of synaptic plasma membranes, Brain Res. 42: 508–513.

    PubMed  CAS  Google Scholar 

  • Barondes, S. H., 1970, Brain glycomacromolecules and interneuronal recognition, in: The Neurosciences: Second Study Program ( F. O. Schmitt, ed.), pp. 747–760, Rockefeller University Press, New York.

    Google Scholar 

  • Barondes, S. H., 1974, Synaptic macromolecules: Identification and metabolism, Annu. Rev. Biochem. 43: 147–168.

    PubMed  CAS  Google Scholar 

  • Barondes, S. H., 1976 (ed.), Neuronal Recognition, Plenum Press, New York.

    Google Scholar 

  • Barondes, S. H.,and Rosen, S. D., 1976, Cell surface carbohydrate-binding proteins: Role in cell recognition, in: Neuronal Recognition ( S. H. Barondes, ed.), pp. 331–356, Plenum Press, New York.

    Google Scholar 

  • Bittiger, H., 1976, Fractionation of rat brain by affinity binding on concanavalin A-sepharose: Separation of mitochondria and postsynaptic densities, Brain Res. 24: 5–6.

    Google Scholar 

  • Bittiger, H.,and Schnebli, H. P., 1974, Binding of concanavalin A and ricin to synaptic junctions of rat brain, Nature (London) 249: 370–371.

    Google Scholar 

  • Blomberg, F., Cohen, R. S., and Siekevitz, P., 1977, The structure of postsynaptic densities isolated from dog cerebral cortex. II. Characterization and arrangement of some of the major proteins within the structure, J. Cell Biol. 74: 204–225.

    PubMed  CAS  Google Scholar 

  • Bondareff, S. and Sjdstrand, J., 1969, Cytochemistry of synaptosomes, Exp. Neurol. 24: 450–458.

    PubMed  CAS  Google Scholar 

  • Brackenbury, R., Thiery, J.-P., Rutishauser, U., and Edelman, G. M., 1977, Adhesion among neural cells of the chick embryo. I. An immunological assay for molecules involved in cell- cell binding, J. Biol. Chem. 252: 6835–6840.

    PubMed  CAS  Google Scholar 

  • Breckenridge, W. C., Breckenridge, J. E., and Morgan, I. G., 1972, Glycoproteins of the synaptic region, Adv. Exp. Med. Biol. 32: 135–153.

    PubMed  CAS  Google Scholar 

  • Bretscher, M. S., and Raff, M. C., 1975, Mammalian plasma membranes, Nature (London) 258: 43–49.

    CAS  Google Scholar 

  • Brunngraber, E. G., 1969, Possible role of glycoproteins in neural function, Perspect. Biol. Med. 12: 467–470.

    PubMed  CAS  Google Scholar 

  • Chiu, T.-C., and Babitch, J. A., 1978, Topography of glycoproteins: The chick synaptosomal plasma membrane, Biochim. Biophys. Acta 570: 112–123.

    Google Scholar 

  • Churchill, L., Cotman, C., Banker, G., Kelly, P., and Shannon, L., 1976, Carbohydrate composition of central nervous system synapses: Analysis of isolated synaptic junctional complexes and postsynaptic densities, Biochim. Biophys. Acta 448: 57–72.

    PubMed  CAS  Google Scholar 

  • Cohen, R. S., Blomberg, F., Berzins, K., and Siekevitz, P., 1977, The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition, J. Cell Biol. 74: 181–203.

    PubMed  CAS  Google Scholar 

  • Cook, G. M. W., and Stoddard, R. W., 1973, Surface Carbohydrates of the Eukaryotic Cell, pp. 257–270, Academic Press, New York.

    Google Scholar 

  • Cotman, C. W., 1974, Isolation of synaptosomal and synaptic plasma membrane fractions, Methods Enzymol. 31: 445–452.

    PubMed  CAS  Google Scholar 

  • Cotman, C. W., and Taylor, D., 1972, Isolation and structural studies on synaptic complexes from rat brain, J. Cell Biol. 55: 696–711.

    PubMed  CAS  Google Scholar 

  • Cotman, C. W., and Taylor, D., 1974, Localization and characterization of concanavalin A receptors in the synaptic cleft, Cell Biol. 62: 226–242.

    Google Scholar 

  • Cotman, C. W., Banker, G., Churchill, L., and Taylor, D., 1974, Isolation of postsynaptic densities from rat brain, J. Cell Biol. 63: 441–455.

    PubMed  CAS  Google Scholar 

  • Dahl, J. L., and Hokin, L. E., 1974, The sodium-potassium adenosinetriphosphatase, Annu. Rev. Biochem. 43: 327–356.

    PubMed  CAS  Google Scholar 

  • Davis, G. A., and Bloom, F. E., 1973, Isolation of synaptic junctional complexes from rat brain, Brain Res. 62: 135–153.

    PubMed  CAS  Google Scholar 

  • Dicesare, J. L., and Rapport, M. M., 1973, Availability of neuraminidase of gangliosides and sialoglycoproteins in neuronal membranes, J. Neurochem. 20: 1781–1783.

    CAS  Google Scholar 

  • Eccles, J. C., Ito, M., and Szentagothai, J., 1967, The Cerebellum as a Neuronal Machine, Springer-Verlag, Berlin.

    Google Scholar 

  • Edds, M. V., Barkley, D. S., and Fambrough, D. M. (eds.), 1973, Genesis of Neuronal Patterns, NRP Bulletin, Vol. 10, No. 3.

    Google Scholar 

  • Edelman, G. M., 1976, Surface modulation in cell recognition and cell growth, Science 192: 218–226.

    PubMed  CAS  Google Scholar 

  • Fiszer, S., and de Robertis, E., 1967, Action of Triton X-100 on ultrastructure and membrane- bound enzymes of isolated nerve endings from rat brain, Brain Res. 5: 31–44.

    CAS  Google Scholar 

  • Fried, R. C., and Blaustein, M. P., 1978, Retrieval and recycling of synaptic vesicle membrane in pinched-off nerve terminals (synaptosomes), J. Cell Biol. 78: 685–700.

    PubMed  CAS  Google Scholar 

  • Garfield, S., Hausmann, R. E., and Moscona, A. A., 1974, Embryonic cell aggregation: Absence of galactosyltransferase activity in retina-specific cell-aggregating factor, Cell Differ. 3: 215–219.

    PubMed  CAS  Google Scholar 

  • Gerisch, G., 1977, Membrane sites implicated in cell adhesion: Their developmental control in Dictyostelium diseoideum, in: Cell Biology 1976–77 ( B. R. Brinkley and K. P. Porter, eds.), pp. 36–42, Rockefeller University Press, New York.

    Google Scholar 

  • Gombos, G., and Zanetta, J.-P., 1977, Recent methods for the separation and analysis of central nervous system glycoproteins, Res. Methods Neurochem. 4: 307–363.

    Google Scholar 

  • Gombos, G., Chandour, M. S., Vincendon, G., Reeber, A., and Zanetta, J.-P., 1977, Formation of the neuronal circuitry of rat cerebellum: Plasma membrane modifications, in: Maturation of Neurotransmission ( E. Giacobini, A. Vernadakis, and S. Karger, eds.), Symposium on Maturation Aspects of Neurotransmission Mechanisms, Saint Vincent (Aosta), Italy.

    Google Scholar 

  • Guidotti, G., 1976, The structure of membrane transport systems, Trends Biochem. Sci. 1: 11–13.

    CAS  Google Scholar 

  • Gurd, J. W., 1976, Fractionation of rat brain acetylcholinesterase by lectin affinity chromatography, J. Neurochem. 27: 1257–1259.

    PubMed  CAS  Google Scholar 

  • Gurd, J. W., 1977a, Synaptic plasma membrane glycoproteins: Molecular identification of lectin receptors, Biochemistry 16: 369–374.

    PubMed  CAS  Google Scholar 

  • Gurd, J. W., 1977b, Identification of lectin receptors associated with rat brain postsynaptic densities, Brain Res. 126:154–159.

    Google Scholar 

  • Gurd, J. W., 1978, Biosynthesis of synaptic membranes: Incorporation of [3H]leucine into proteins and glycoproteins of rat brain synaptic plasma membranes, Brain Res. 142: 201–204.

    Google Scholar 

  • Gurd, J. W., and Mahler, H. R., 1974, Fractionation of synaptic plasma membrane glycoproteins by lectin affinity chromatography, Biochemistry 13: 5193–5198.

    PubMed  CAS  Google Scholar 

  • Gurd, J. W., Jones, L. R., Mahler, H. R., and Moore, W. J., 1974, Isolation and partial characterization of rat brain synaptic plasma membranes, J. Neurochem. 22: 281–290.

    PubMed  CAS  Google Scholar 

  • Heuser, J. E., 1977, Synaptic vesicle exocytosis revealed in quick-frozen frog neuromuscular junctions treated with 4-amino-pyridine and given a single electrical shock, in: Society for Neuroscience Symposia, Vol. II, Approaches to the Cell Biology of Neurons ( W. M. Cowan and J. A. Ferrendelli, eds.), pp. 215–239, Society for Neuroscience, Bethesda, Maryland.

    Google Scholar 

  • Hughes, R. C., 1976, Membrane Glycoproteins: A Review of Structure and Function, Butter- worths, London.

    Google Scholar 

  • Jones, D. H.,and Matus, A. I., 1974, Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation, Biochim, Biophys. Acta 356: 276–287.

    CAS  Google Scholar 

  • Kelly, P. T., and Cotman, C. W., 1977, Identification of glycoproteins, proteins at synapses in the central nervous system, J. Biol. Chem. 252: 786–793.

    PubMed  CAS  Google Scholar 

  • Kelly, P. T., and Cotman, C. W., 1978, Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide, J. Cell Biol 79: 173–183.

    PubMed  CAS  Google Scholar 

  • Kelly, P., Cotman, C. W., Gentry, C., and Nicolson, G. L., 1976, Distribution and mobility of lectin receptors on synaptic membranes of identified neurons in the central nervous system, J. Cell Biol 71: 487–496.

    PubMed  CAS  Google Scholar 

  • Kobiler, D., and Barondes, S. H., 1978, Lectin activity from embryonic chick brain, heart and liver: Changes with development, Dev. Biol 60: 326–330.

    Google Scholar 

  • Kobiler, D., Beyer, E. C., and Barondes, S. H., 1978, Developmentally regulated lectins from chick muscle, brain, and liver have similar chemical and immunological properties, Dev. Biol 64: 265–272.

    PubMed  CAS  Google Scholar 

  • Krusius, T., Finne, J., Margolis, R. U.,and Margolis, R. K., 1978, Structural features of microsomal, synaptosomal, mitochondrial and soluble glycoproteins of brain, Biochemistry 17: 3849–3854.

    CAS  Google Scholar 

  • Lis, H., and Sharon, N., 1973, The biochemistry of plant lectins (phytohemagglutinins), Annu. Rev. Biochem. 42: 541–574.

    PubMed  CAS  Google Scholar 

  • Llinas, R. R., and Heuser, J. E. (eds.), 1978, Depolarization-Release Coupling Systems in Neurons, MIT Press, Boston.

    Google Scholar 

  • Mahadik, S. P., Hungund, B., and Rapport, M. M., 1978, Topographic studies of glycoproteins of intact synaptosomes from rat brain cortex, Biochim. Biophys. Acta 511: 240–250.

    PubMed  CAS  Google Scholar 

  • Mahler, H. R., 1977, Proteins of the synaptic membrane, Neurochem. Res. 2: 119–147.

    CAS  Google Scholar 

  • Mahler, H. R., Wang, Y.-J., De Bias, A., and Crawford, G., 1977, Topography of membrane proteins at vertebrate synapses, in: Mechanisms, Regulation and Special Functions of Pro- tein Synthesis in the Brain ( S. Roberts, A. Lajtha, and W. H. Gispen, eds.), pp. 205–220, Elsevier/North-Holland Biomedical Press, New York.

    Google Scholar 

  • Marchisio, P. C., Gremo, F., and Sjostrand, J., 1975, Axonal transport in embryonic neurons: The possibility of a proximo-distal axolemmal transfer of glycoproteins, Brain Res. 85: 281–285.

    PubMed  CAS  Google Scholar 

  • Margolis, R. K., Margolis, R. U., Preti, C., and Lai, D., 1975, Distribution and metabolism of glycoproteins and glycosaminoglycans in subcellular fractions of brain, Biochemistry 14: 4797–4804.

    PubMed  CAS  Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1977, Metabolism and function of glycoproteins and gly-cosaminoglycans in nervous tissue, Int. J. Biochem. 8: 85–91.

    CAS  Google Scholar 

  • Matus, A., 1977, The chemical synapse in structure and function, in: Intracellular Junctions and Synapses in Development ( J. D. Feldman, N. B. Gilula, and J. O. Pitts, eds.), Chapman and Hall, London.

    Google Scholar 

  • Matus, A. I., and Taff-Jones, D. H., 1978, Morphology and molecular composition of isolated postsynaptic junctional structures, Proc. R. Soc. London Ser. 2? 203: 135–151.

    CAS  Google Scholar 

  • Matus, A. I., and Walters, B. B., 1976, Type 1 and 2 synaptic junctions: Differences in distribution of concanavalin A binding sites and stability of the junctional adhesion, Brain Res. 108: 249–256.

    PubMed  CAS  Google Scholar 

  • Matus, A., De Petris, S., and Raff, M. C., 1973, Mobility of concanavalin A receptors in myelin and synaptic membranes, Nature (London) New Biol. 244: 278–279.

    CAS  Google Scholar 

  • McBride, W. J., Mahler, H. R., Moore, W. J., and White, F. P., 1970, Isolation and characterization of membranes from rat cerebral cortex, J. Neurobiol. 2: 73–92.

    PubMed  CAS  Google Scholar 

  • McQuarrie, C., Salvaterra, P. M., De Bias, A., Routes, J., and Mahler, H. R., 1976, Studies on nicotinic acetylcholine receptors in mammalian brain. V. Preliminary characterization of membrane bound a-bungarotoxin receptors in rat cerebral cortex, J. Biol. Chem. 251: 6335–6339.

    PubMed  CAS  Google Scholar 

  • McQuarrie, C., Salvaterra, P. M.,and Mahler, H. R., 1978, Studies on nicotinic acetylcholine acceptors in mammalian brain. Interaction of solubilized protein with cholinergic ligands, J. Biol. Chem. 253: 2743–1247.

    CAS  Google Scholar 

  • Michaelis, E. K., Michaelis, M. L.,and Boyarski, L. L., 1974, High-affinity glutamic acid binding to brain synaptic membranes, Biochim. Biophys. Acta 367: 338–348.

    CAS  Google Scholar 

  • Mintz, G., and Glaser, L., 1978, Specific glycoprotein changes during development of the chick neural retina, J. Cell Biol. 79: 132–137.

    PubMed  CAS  Google Scholar 

  • Morgan, I. G., 1976, Synaptosomes and cell separation, Neuroscience 1: 159–165.

    PubMed  CAS  Google Scholar 

  • Morgan, I. G., and Gombos, G., 1976, Biochemical studies of synaptic macromolecules: Are there specific synaptic components?, in: Neuronal Recognition ( S. H. Barondes, ed.), pp. 179–202, Plenum Press, New York.

    Google Scholar 

  • Morgan, I. G., Breckenridge, W. C., Vincendon, G., and Gombos, G., 1973A, The proteins of nerve-ending membranes, in: Proteins of the Nervous System (D. J. Schneider, R. H. Angeletti, R. A. Bradshaw, A. Grasso, and B. W. Moore, eds.), pp. 171–192, Raven Press, New York.

    Google Scholar 

  • Morgan, I. G., Marinari, U. M., Dutton, G. R., Vincendon, G.,and Gombos, G., 19736, The biosynthesis of synaptic glycoproteins, in: Methodologie de la Structure et du Metabolisme des Glycoconjugues (Glycoproteins et Glycolipids), Vol. 2, pp. 1043–1055, CNRS, Paris.

    Google Scholar 

  • Morgan, I. G., Zanetta, J.-P., Breckenridge, W. C., Vincendon, G., and Gombos, G., 1973c, The chemical structure of synaptic membranes, Brain Res. 62: 405–411.

    PubMed  CAS  Google Scholar 

  • Morgan, I. G., Gombos, G., and Tettamanti, G., 1977a, Glycoproteins and glycolipids of the nervous system, in: The Glycoconjugates, Vol. 1 ( M. I. Horowitz and W. Pigman, eds.), pp. 351–383, Academic Press, New York.

    Google Scholar 

  • Morgan, I. G., Woolstron, M. E., and Hambley, J. W., 1977B, Biochemical studies of synaptic macromolecules: The developing chick visual system, in: Mechanisms, Regulation and Special Functions of Protein Synthesis in the Brain (S. Roberts, A. Lajtha, and W. H. Gispen, eds.), pp. 231–246, Elsevier/North-Holland Biomedical Press, New York.

    Google Scholar 

  • Moscona, A. A., 1974, Surface specification on embryonic cells: Lectin receptors, cell recognition, and specific cell ligands, in: The Cell Surface in Development ( A. A. Moscona, ed.), pp. 67–99, John Wiley & Sons, New York.

    Google Scholar 

  • Oseroff, A. R., Robbins, P. W., auyond Burger, M. M., 1973, The cell surface membrane: Biochemical aspects and biophysical probes, Annu. Rev. Biochem. 42: 648–682.

    Google Scholar 

  • Rambourg, A., and LeBlond, C. P., 1967, Electron microscope observations on the carbo- hydrate-rich cell coat present at the surface of cells in the rat, J. Cell Biol. 32: 27–53.

    PubMed  CAS  Google Scholar 

  • Rapport, M. M., and Mahadik, S. P., 1977, Topographic studies of glycoproteins and gangliosides in the surface of intact synaptosomes, in: Mechanisms, Regulation and Special Functions of Protein Synthesis in the Brain ( S. Roberts, A. Lajatha, and W. H. Gispen, eds.), pp. 221–230, Elsevier/North-Holland Biomedical Press, New York.

    Google Scholar 

  • Reith, M., Morgan, I. G., Gombos, G., Breckenridge, W. C.,and Vincendon, G., 1972, Synthesis of synaptic glycoproteins. I. The distribution of UDP-galactose: N-acetyl glucosamine galactosyl transferase and thiamine diphosphatase in adult rat brain subcellular fractions, Neurobiology 2: 169–175.

    CAS  Google Scholar 

  • Roseman, S., 1970, The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion, Chem. Phys. Lipids 5: 270–297.

    PubMed  CAS  Google Scholar 

  • Rostas, J. A., Kelly, P. T., and Cotman, C. W., 1977, The identification of membrane glycocom- ponents in polyacrylamide gels: A rapid method using 125I-labeled lectins, Anal. Biochem. 80: 366–372.

    PubMed  CAS  Google Scholar 

  • Roth, R. S., 1973, A molecular model for cell interactions, Q. Rev. Biol. 48: 541–562.

    Google Scholar 

  • Rothman, J. E., and Lenard, J., 1977, Membrane asymmetry, Science 195: 743–753.

    PubMed  CAS  Google Scholar 

  • Salvaterra, P. M., and Mahler, H. R., 1976, Nicotinic acetylcholine receptor from rat brain: Solubilization, partial purification and characterization, J. Biol. Chem. 251: 6326–6334.

    Google Scholar 

  • Salvaterra, P. M., Gurd, J. M., and Mahler, H. R., 1977, Interactions of the nicotinic acetylcholine receptor from rat brain with lectins, J. Neurochem. 29: 345–348.

    PubMed  CAS  Google Scholar 

  • Schubert, D., Harris, A. J., Heinemann, S., Kidokoro, Y., Patrick, J., and Steinbach, J. H., 1973, Differentiation and interaction of clonal cell lines of nerve and muscle, in: Tissue Culture of the Nervous System ( G. Sato, ed.), pp. 55–85, Plenum Press, New York.

    Google Scholar 

  • Seeds, N. W., 1973, Differentiation of aggregating brain cell cultures, in: Tissue Culture of the Nervous System ( G. Sato, ed.), pp. 35–53, Plenum Press, New York.

    Google Scholar 

  • Sharon, N., 1975, Complex Carbohydrates: Their Chemistry, Biosynthesis and Function, pp. 26- 29, 177–190, Addison-Wesley, Reading, Massachusetts.

    Google Scholar 

  • Shur, B. D., and Roth, S., 1975, Cell surface glycosyltransferase, Biochim. Biophys. Acta 415: 473–512.

    PubMed  CAS  Google Scholar 

  • Simpson, D. L., Thorne, D. R., and Loh, H. H., 1976, Sulfated glycoproteins, glycolipids, and glycosaminoglycans from synaptic plasma and myelin membranes: Isolation and characterization of sulfated glycopeptides, Biochemistry 15: 5449–5457.

    PubMed  CAS  Google Scholar 

  • Simpson, D. L., Thorne, D. R., and Loh, H. H., 1977, Developmentally regulated lectin in neonatal rat brain, Nature (London) 226: 367–369.

    Google Scholar 

  • Stefanovic, V., Mandel, P., and Rosenberg, A., 1975, Activation of acetyl-and butyrylcholines- terase by enzymatic removal of sialic acid from intact neuroblastoma and astroblastoma cells in culture, Biochemistry 14: 5257–5260.

    PubMed  CAS  Google Scholar 

  • Susz, J. P., Hof, H. I., and Brunngraber, E. G., 1973, Isolation of concanavalin A binding glycoproteins from rat brain, FEBS Lett. 32: 289–292.

    PubMed  CAS  Google Scholar 

  • Tettamanti, G., Morgan, I. G., Gombos, G., Vincendon, G., and Mandel, P., 1972, Sub-synap- tosomal localization of brain particulate neuraminidase, Brain Res. 47: 515–518.

    PubMed  CAS  Google Scholar 

  • Tettamanti, G., Preti, A., Lombardo, A., Suman, T., and Zambotti, V., 1975, Membrane- bound neuraminidase in the brain of different animals: Behaviour of the enzyme on endogenous sialo derivatives and rationale for its assay, J. Neurochem. 25: 451 - 456.

    PubMed  CAS  Google Scholar 

  • Thiery, J.-P., Brackenbury, R., Rutishause, U., and Edelman, G. M., 1977, Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina, J. Biol. Chem. 252: 6841–6845.

    PubMed  CAS  Google Scholar 

  • Van Nieuw Amerongen, A., and Roukema, P. A., 1974, GP-350, a sialoglycoprotein from calf brain: Its subcellular localization and occurrence in various brain areas, J. Neurochem. 23: 85–89.

    PubMed  Google Scholar 

  • Vincendon, G., Gombos, G., and Morgan, I. G., 1973, The interest of studying glycoproteins in the central nervous system, in: Methodologie de la Structure et du Metabolisme des Glyco-conjugues (Glycoproteins et Glycolipids), Vol. 2, CNRS, Paris.

    Google Scholar 

  • Walters, B. B., and Matus, A. I., 1975a, Ultrastructure of the synaptic junctional lattice from mammalian brain, J. Neurocytol. 4: 369–375.

    PubMed  Google Scholar 

  • Walters, B. B., and Matus, A. I., 1975b, Proteins of the synaptic junction, Biochem. Soc. Trans. 3:109–112.

    Google Scholar 

  • Walters, B. B., and Matus, A. I., 1975c, Tubulin in postsynaptic junctional lattice, Nature (London) 257: 496–498.

    CAS  Google Scholar 

  • Wang, Y.-J., and Mahler, H. R., 1976, Topography of the synaptosomal plasma membrane, J. Cell Biol. 71: 639–658.

    PubMed  CAS  Google Scholar 

  • Wenthold, R. J., Mahler, H. R., and Moore, W. J., 1974, Properties of rat brain acetylcholinesterase, J. Neurochem. 22: 945–949.

    PubMed  CAS  Google Scholar 

  • Whittaker, V. P., Michaelson, I. A., and Kirkland, R. J. A., 1964, The separation of synaptic vesicles from nerve-ending particles (“synaptosomes”), Biochem. J. 90: 293–303.

    PubMed  CAS  Google Scholar 

  • Yohe, H. C., and Rosenberg, A., 1977, Action of intrinsic sialidase of rat brain synaptic membranes on membrane sialolipid and sialoprotein components in situ, J. Biol. Chem. 252: 2412–2418.

    PubMed  CAS  Google Scholar 

  • Zanetta, J. P., and Gombos, G., 1974, Affinity chromatography on Con A-Sepharose of synaptic vesicle membrane glycoproteins, FEBS Lett. 47: 276–478.

    PubMed  CAS  Google Scholar 

  • Zanetta, J. P., Breckenridge, W. C., and Vincendon, C., 1972, Analysis of monosaccharides by gas-liquid chromatography of the 0-methyl glycosides as trifluoroacetate derivatives: Application to glycoprotein and glycolipids, J. Chromatogr. 69: 291–304.

    PubMed  CAS  Google Scholar 

  • Zanetta, J. P., Morgan, I. G., and Gombos, G., 1975, Synaptosomal plasma membrane glycoproteins: Fractionation by affinity chromatography on concanavalin A, Brain Res. 83: 337–348.

    PubMed  CAS  Google Scholar 

  • Zanetta, J. P., Reeber, A., Ghandour, M. S., Vincendon, G., and Gombos, G., 1977a, Glycoproteins of intrasynaptosomal mitochondria, Brain Res. 125: 386–389.

    PubMed  CAS  Google Scholar 

  • Zanetta, J. P., Reeber, A., Vincendon, G. and Gombos, G., 1977b, Synaptosomal plasma membrane glycoproteins. II. Isolation of fucosyl-glycoproteins by affinity chromatography on the Ulex europeus lectin specific for L-fucose, Brain Res. 138:317–328.

    CAS  Google Scholar 

  • Zanetta, J. P., Roussel, G., Ghandour, M. S., Vincendon, G., and Gombos, G., 1978, Postnatal development of rat cerebellum: Massive and transient accumulation of concanavalin A binding glycoproteins in parallel fiber axolemma, Brain Res. 142: 301–319.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular and Cellular Biology Program and Department of Chemistry, Indiana University, Bloomington, Indiana, USA

    Henry R. Mahler

Authors
  1. Henry R. Mahler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New York University Medical Center, New York, New York, USA

    Richard U. Margolis

  2. Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Renée K. Margolis

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Mahler, H.R. (1979). Glycoproteins of the Synapse. In: Margolis, R.U., Margolis, R.K. (eds) Complex Carbohydrates of Nervous Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2925-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2925-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2927-5

  • Online ISBN: 978-1-4613-2925-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation