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Complex Carbohydrates of Nervous Tissue

  • Richard U. Margolis
  • Renée K. Margolis

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Robert W. Ledeen
    Pages 1-23
  3. Abraham Rosenberg
    Pages 25-43
  4. Renée K. Margolis, Richard U. Margolis
    Pages 45-73
  5. C. J. Waechter, M. G. Scher
    Pages 75-102
  6. George W. Jourdian
    Pages 103-125
  7. Robert R. Townsend, Yu-Teh Li, Su-Chen Li
    Pages 127-137
  8. John G. Wood, Barbara J. McLaughlin
    Pages 139-164
  9. Henry R. Mahler
    Pages 165-184
  10. Karl H. Pfenninger, Marie-France Maylié-Pfenninger
    Pages 185-191
  11. Richard H. Quarles
    Pages 209-233
  12. Richard T. Ambron, James H. Schwartz
    Pages 269-289
  13. Giuliana Giannattasio, Antonia Zanini, Jacopo Meldolesi
    Pages 327-345
  14. Richard U. Margolis, Renée K. Margolis
    Pages 377-386
  15. Back Matter
    Pages 397-401

About this book

Introduction

It is only relatively recently that neurochemists and neurobiologists have shown appreciable interest in the class of macromolecules now generally re­ ferred to as complex carbohydrates, although gangliosides were, of course, first identified and studied in brain. The glycosaminoglycans fell chiefly within the province of connective-tissue biochemists, and earlier informa­ tion concerning the structure and metabolism of glycoproteins was largely limited to the more accessible glycoproteins and oligosaccharides (such as those found in plasma, milk, and urine), or ones which are relatively simple to prepare in a soluble and manageable form. Techniques were later devised for the isolation and purification of tightly bound membrane glycoproteins, where initial studies concentrated mainly on the erythrocyte, for which large amounts of a single cell population are available. Because of the structural complexity of nervous tissue and the large numbers, low concentrations, and membrane-bound form of many of its complex carbohydrates, progress has occurred more slowly in this area.

Keywords

adenosine brain carbohydrates cognition complexity myelin nervous system neurons tumor

Editors and affiliations

  • Richard U. Margolis
    • 1
  • Renée K. Margolis
    • 2
  1. 1.New York University Medical CenterNew YorkUSA
  2. 2.Downstate Medical CenterState University of New YorkBrooklynUSA

Bibliographic information