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Structure and Distribution of Glycoproteins and Glycosaminoglycans

  • Chapter
Complex Carbohydrates of Nervous Tissue

Abstract

The glycosaminoglycans (called mucopolysaccharides in the older nomenclature) are high-molecular-weight linear carbohydrate polymers that are generally composed of disaccharide repeating units of a uronic acid (D-gluc- uronic acid or L-iduronic acid) and a hexosamine (N-acetylglucosamine or N-acetylgalactosamine). In the case of the sulfated glycosaminoglycans, the polysaccharide chains are O-glycosidically linked at their reducing ends to a protein moiety through the characteristic -glucuronosyl-galactosyl- galactosyl-xylosyl-serine sequence.

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References

  • Adams, C. W. M., and Bayliss, O. B., 1968, Histochemistry of myelin. VII. Analysis of lipid-protein relationships and absence of acid mucopolysaccharide, J. Histochem. Cytochem. 16: 119.

    Article  PubMed  CAS  Google Scholar 

  • Akasaki, M., Kawasaki, T., and Yamashina, I., 1975, The isolation and characterization of glycopeptides and mucopolysaccharides from plasma membranes of normal and regenerating livers of rats, FEBS Lett. 59: 100.

    Article  PubMed  CAS  Google Scholar 

  • Allen, W. S., Otterbein, C., Varma, R., Varma, R. S., and Wardi, A. H., 1976, Nondialyzable sulfated sialoglycopeptide fractions derived from bovine heifer brain glycoproteins: Isolation, characterization, and carbohydrate-peptide linkage studies, J. Neurochem. 26: 879.

    Article  PubMed  CAS  Google Scholar 

  • Balazs, E. A. (ed.), 1970, Chemistry and Biology of the Intercellular Matrix, Vol. 2, Glycosaminoglycans and Proteoglycans, Academic Press, London.

    Google Scholar 

  • Balsamo, J., and Lilien, J., 1975, The binding of tissue-specific adhesive molecules to the cell surface: A molecular basis for specificity, Biochemistry 14: 167.

    Article  PubMed  CAS  Google Scholar 

  • Barondes, S. H., 1974, Synaptic macromolecules: Identification and metabolism, Annu. Rev. Biochem. 43: 147.

    Article  PubMed  CAS  Google Scholar 

  • Behnke, O., 1975, Studies on isolated microtubules: Evidence for a clear space component, Cytobiologie 11: 366.

    Google Scholar 

  • Bhavanandan, V. P., and Davidson, E. A., 1975, Mucopolysaccharides associated with nuclei of cultured mammalian cells, Proc. Natl. Acad. Sci. U.S.A. 72: 2032.

    Article  PubMed  CAS  Google Scholar 

  • Bogoch, S., 1968, The Biochemistry of Memory, Oxford University Press, New York.

    Google Scholar 

  • Bondareff, W., 1967, Demonstration of an intercellular substance in mouse cerebral cortex, Z. Zellforsch. 81: 366.

    Article  PubMed  CAS  Google Scholar 

  • Branford White, C. J., and Hudson, M., 1977, Characterization of a chondroitin sulphate proteoglycan from ovine brain, J. Neurochem. 28: 581.

    Article  Google Scholar 

  • Brunngraber, E. G., 1972, Biochemistry, function and neuropathology of glycoproteins in brain tissue, in: Functional and Structural Proteins of the Nervous System (A. N. Davison, P. Mandel, and I. G. Morgan, eds.), pp. 109–133, Plenum Press, New York.

    Google Scholar 

  • Brunngraber, E. G., and Brown, B. D., 1964, Fractionation of brain macromolecules. II. Isolation of protein-linked sialomucopolysaccharides from subcellular, particulate fractions from rat brain, J. Neurochem. 11: 449.

    Article  PubMed  CAS  Google Scholar 

  • Brunngraber, E. G., Aro, A., and Brown, B. D., 1970, Differential determination of glucosamine, galactosamine, and mannosamine in glycopeptides derived from brain tissue glycoproteins, Clin. Chim. Acta 29: 333.

    Article  PubMed  CAS  Google Scholar 

  • Brunngraber, E. G., Hof, H., Susz, J., Brown, B. D., Aro, A., and Chang, I., 1973, Glycopeptides from rat brain glycoproteins, Biochim. Biophys. Acta 304: 781.

    Article  PubMed  CAS  Google Scholar 

  • Brunngraber, E. G., Susz, J. P., and Warecka, K., 1974, Electrophoretic analysis of human brain- specific proteins obtained by affinity chromatography, J. Neurochem. 22: 181.

    Article  PubMed  CAS  Google Scholar 

  • Brunngraber, E. G., Susz, J. P., Javaid, J., Aro, A., and Warecka, K., 1975, Binding of concan- avalin A to the brain-specific proteins obtained from human white matter by affinity chromatography, J. Neurochem. 24: 805.

    CAS  Google Scholar 

  • Buonassisi, V., and Root, M., 1975, Enzymatic degradation of heparin-related mucopolysaccharides from the surface of endothelial cell cultures, Biochim. Biophys. Acta 385: 1.

    Article  PubMed  CAS  Google Scholar 

  • Castejon, H. V., 1970, Histochemical demonstration of acid glycosaminoglycans in the nerve cell cytoplasm of mouse central nervous system, Acta Histochem. 35: 161.

    PubMed  CAS  Google Scholar 

  • Castejon, H. V., and Castejon, O. J., 1976, Electron microscopic demonstration of hyaluronidase sensible proteoglycans at the presynaptic area in mouse cerebellar cortex, Acta Histochem. 55: 300.

    PubMed  CAS  Google Scholar 

  • Chandrasekaran, E. V., BeMiller, J. N., and Leer, S.-C. D., 1978, Isolation, partial characterization, and biological properties of polysaccharides from papain, Carbohydr. Res. 60: 105.

    Article  PubMed  CAS  Google Scholar 

  • Comper, W. D., and Laurent, T. C., 1978, Physiological function of connective tissue polysaccharides, Physiol. Rev. 58: 255.

    PubMed  CAS  Google Scholar 

  • Davis, L. G., Costello, A. J. R., Javaid, J. I., and Brunngraber, E. G., 1976A, 31P nuclear magnetic resonance studies on the phosphoglycopeptides obtained from rat brain glycoprotein, FEBS Lett. 65:35.

    Article  CAS  Google Scholar 

  • Davis, L. G., Javaid, J. I., and Brunngraber, E. G., 1976b, Identification of phosphoglycopro- teins obtained from rat brain, FEBS Lett. 65: 30.

    Article  PubMed  CAS  Google Scholar 

  • Dawson, G., and Tsay, G., 1977, Substrate specificity of human a-L-fucosidase, Arch. biochem. Biophys. 184: 12.

    Article  PubMed  CAS  Google Scholar 

  • Di Benedetta, C., Brunngraber, E. G., Whitney, G., Brown, B. D., and Aro, A., 1969, Compositional patterns of sialofucohexosaminoglycans derived from rat brain glycoproteins, Arch. biochem. Biophys. 131: 404.

    Article  PubMed  Google Scholar 

  • Dietrich, C. P., Sampaio, L. O., and Toledo, O. M. S., 1976, Characteristic distribution of sulfated mucopolysaccharides in different tissues and their respective mitochondria, Biochem. Biophys. Res. Commun. 71: 1.

    Article  PubMed  CAS  Google Scholar 

  • Dorai, D. T., and Bachhawat, B. K., 1977, Purification and properties of brain alkaline phosphatase, J. Neurochem. 29: 503.

    Article  PubMed  CAS  Google Scholar 

  • Dutton, G. R., and Barondes, S. H., 1970, Glycoprotein metabolism in developing mouse brain, J. Neurochem. 17: 913.

    Article  PubMed  CAS  Google Scholar 

  • Eipper, B. A., 1972, Rat brain microtubule protein: Purification and determination of cova- lently bound phosphate and carbohydrate, Proc. Natl. Acad. Sci. U.S.A. 69: 2283.

    Article  PubMed  CAS  Google Scholar 

  • Feit, H., and Shelanski, M. L., 1975, Is tubulin a glycoprotein?, Biochem. Biophys. Res. Commun. 66: 920.

    Article  PubMed  CAS  Google Scholar 

  • Finne, J., 1975, Structure of the O-glycosidically linked carbohydrate units of rat brain glycoproteins, Biochim. Biophys. Acta 412: 317.

    PubMed  CAS  Google Scholar 

  • Finne, J., and Krusius, T., 1976, O-glycosidic carbohydrate units from glycoproteins of different tissues: Demonstration of a brain-specific disaccharide, α-galactosyl-(l→3)-N-acetylgalactosamine, FEBS Lett. 66: 94.

    Article  PubMed  CAS  Google Scholar 

  • Finne, J., and Rauvala, H., 1977, Determination (by methylation analysis) of the substitution pattern of 2-amino-2-deoxyhexitols obtained from O-glycosylic carbohydrate units of glycoproteins, Carbohydr. Res. 58: 57.

    Article  PubMed  CAS  Google Scholar 

  • Finne, J., Krusius, T., Rauvala, H., and Hemminki, K., 1977, The disialosyl group of glycoproteins: Occurrence in different tissues and cellular membranes, Eur. J. Biochem. 77: 319.

    Article  PubMed  CAS  Google Scholar 

  • Finne, J., Krusius, T., Margolis, R. K., and Margolis, R. U., 1979. Novel mannitol-containing oligosaccharides obtained by mild alkaline borohydride treatment of a chondroitin sulfate proteoglycan from brain (submitted for publication).

    Google Scholar 

  • Glimelius, B., Norling, B., Westermark, B., and Wasteson, A., 1978, Composition and distribution of glvcosaminoglycans in cultures of human normal and malignant glial cells, Biochem. J. 172: 443.

    PubMed  CAS  Google Scholar 

  • Gombos, G., and Zanetta, J. P., 1978, Recent methods for the separation and analysis of central nervous system glycoproteins, in: Research Methods in Neuro chemistry, Vol. 4 ( N. Marks and R. Rodnight, eds.), pp. 307–343, Plenum Press, New York.

    Google Scholar 

  • Gottschalk, A. (ed.), 1972, Glycoproteins Their Composition, Structure and Function, 2nded., Elsevier, Amsterdam.

    Google Scholar 

  • Hughes, R.C., 1976, Membrane Glycoproteins A Review of Structure and Function, Butter- worths, London.

    Google Scholar 

  • Hüttich, K., Müller, H., and Unger, E., 1977, Concanavalin A-Bindung an zyklisch reassem- blierte Mikrotubuli aus Schweinehirn-Tubulin, Acta Histochem. 58: 324.

    PubMed  Google Scholar 

  • Katzman, R. L., 1972, Isolation of N-acetyllactosamine and galactosyl-jS-D-(l→4)-N-acetyl- lactosamine from beef brain glycopeptides, J. Biol. Chem. 247: 3744.

    PubMed  CAS  Google Scholar 

  • Katzman, R. L., 1974, Absence of arabinose in bovine brain hyaluronic acid as analysed by gas-liquid chromatography and mass spectrometry, Biochim. Biophys. Acta 372: 52.

    Article  CAS  Google Scholar 

  • Kiang, W.-L., Crockett, C. P., Margolis, R. K., and Margolis, R. U., 1978, Glycosaminoglycans and glycoproteins associated with microsomal subfractions of brain and liver, Biochemistry 17: 3841.

    Article  PubMed  CAS  Google Scholar 

  • Kornfeld, R., and Kornfeld, S., 1976, Comparative aspects of glycoprotein structure, Annu. Rev. Biochem. 45: 217.

    Article  PubMed  CAS  Google Scholar 

  • Kraemer, P. M., 1971, Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cells, Biochemistry 10: 1437.

    Article  PubMed  CAS  Google Scholar 

  • Kraemer, P. M., and Smith, D. A., 1974, High molecular weight heparan sulfate from the cell surface, Biochem. Biophys. Res. Commun. 56: 423.

    Article  PubMed  CAS  Google Scholar 

  • Krusius, T., and Finne, J., 1977, Structural features of tissue glycoproteins Fractionation and methylation analysis of glycopeptides derived from rat brain, kidney and liver, Eur. J. Biochem. 78: 369.

    Article  PubMed  CAS  Google Scholar 

  • Krusius, T., and Finne, J., 1978, Characterization of a novel sugar sequence from rat brain glycoproteins containing fucose and sialic acid, Eur. J. Biochem. 84: 395.

    Article  PubMed  CAS  Google Scholar 

  • Krusius, T., Finne, J., Karkkainen, J., and Jarnefelt, J., 1974, Neutral and acidic glycopeptides in adult and developing rat brain, Biochim. Biophys. Acta 365: 80.

    PubMed  CAS  Google Scholar 

  • Krusius, T., Finne, J., Margolis, R. U., and Margolis, R. K., 1978, Structural features of microsomal, synaptosomal, mitochondrial and soluble glycoproteins of brain, Biochemistry 17: 3849.

    Article  PubMed  CAS  Google Scholar 

  • Lindahl, U., and Roden, L., 1972, Carbohydrate-peptide linkages in proteoglycans of animal, plant and bacterial origin, in: Glycoproteins—Their Composition, Structure and Function, 2nd ed. ( A. Gottschalk, ed.), pp. 491–517, Elsevier, Amsterdam.

    Google Scholar 

  • Linker, A., and Hovingh, P., 1973, The heparitin sulfates (heparan sulfates), Carbohydr. Res. 29: 41.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., and Margolis, R. U., 1970, Sulfated glycopeptides from rat brain glycoproteins, Biochemistry 9: 4389.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K. and Margolis, R. U., 1973, Alkali-labile oligosaccharides of brain glycoproteins, Biochim. Biophys. Acta 304: 421.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., Margolis, R. U., and Shelanski, M. L., 1972, The carbohydrate composition of brain microtubule protein, Biochem. Biophys. Res. Commun. 47: 432.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., Margolis, R. U., Preti, C., and Lai, D., 1975, Distribution and metabolism of glycoproteins and glycosaminoglycans in subcellular fractions of brain, Biochemistry 14: 4797.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., Crockett, C. P., Kiang, W.-L.,and Margolis, R. U., 1976A, Glycosaminoglycans and glycoproteins associated with rat brain nuclei, Biochim. Biophys. Acta 451:465.

    Google Scholar 

  • Margolis, R. K., Preti, C., Lai, D., and Margolis, R. U., 1976b, Developmental changes in brain glycoproteins, Brain Res. 112: 363.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., Crockett, C. P., and Margolis, R. U., 1978, Dissociative extraction of brain proteoglycans, J. Neurochem. 30: 1177.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., Thomas, M. D., Crockett, C. P., and Margolis, R. U., 1979, Presence of chon- droitin sulfate in the neuronal cytoplasm, Proc. Natl. Acad. Sci. U.S.A. (in press).

    Google Scholar 

  • Margolis, R. U., 1967, Acid mucopolysaccharides and proteins of bovine whole brain, white matter and myelin, Biochim. Biophys. Acta 141: 91.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U., 1969, Mucopolysaccharides, in: Handbook of Neurochemistry, Vol. 1 ( A. Lajtha, ed.), pp. 245–260, Plenum Press, New York.

    Google Scholar 

  • Margolis, R. U., and Atherton, D. M., 1972, The heparan sulfate of rat brain, Biochim. Biophys. Acta 273: 368.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U.,and Margolis, R. K., 1972A, Sulfate turnover in mucopolysaccharides and glycoproteins of brain, Biochim. Biophys. Acta 264:426.

    Article  CAS  Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1972b, Mucopolysaccharides and glycoproteins, in: Research Methods in Neurochemistry, Vol. 1 ( N. Marks and R. Rodnight, eds.), pp. 249–284, Plenum Press, New York.

    Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1974, Distribution and metabolism of mucopolysaccharides and glycoproteins in neuronal perikarya, astrocytes, and oligodendroglia, Biochemistry 13: 2849.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1977, Metabolism and function of glycoproteins and gly-cosaminoglycans in nervous tissue, Int. J. Biochem. 8: 85.

    Article  CAS  Google Scholar 

  • Margolis, R. U., Margolis, R. K., and Atherton, D. M., 1972, Carbohydrate-peptide linkages in glycoproteins and mucopolysaccharides from brain, J. Neurochem. 19: 2317.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U., Margolis, R. K., Chang, L., and Preti, C., 1975, Glycosaminoglycans of brain during development, Biochemistry 14: 85.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U., Lalley, K., Kiang, W.-L., Crockett, C., and Margolis, R. K., 1976, Isolation and properties of a soluble chondroitin sulfate proteoglycan from brain, Biochem. Biophys. Res. Commun. 73: 1018.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U., Margolis, R. K., Kiang, W.-L., and Crockett, C. P., 1978, Soluble proteoglycans and glycoproteins of brain, in: Glycoconjugate Research: Proceedings of the Fourth International Symposium on Glycoconjugates ( J. D. Gregory and R. W. Jeanloz, eds.), Academic Press, New York.

    Google Scholar 

  • Matthieu, J.-M., Quarles, R. H., Poduslo, J. F., and Brady, R. O., 1975a, [35S]Sulfate incorporation into myelin glycoproteins. I. Central nervous system, Biochim. Biophys. Acta 392:159.

    Article  CAS  Google Scholar 

  • Matthieu, J.-M., Everly, J. L., Brady, R. O., and Quarles, R. H., 1975B, [35S]Sulfate incorporation into myelin glycoproteins. II. Peripheral nervous system, Biochim. Biophys. Acta 392:167.

    Article  Google Scholar 

  • Montreuil, M. J. (ed.), 1974, Actes Colloq. Int. No. 221 (2e Symposium International sur les Glycoconjugues, “La Méthodologie de la Structure et du Metabolisme des Glycoconjugues,” organise a Villeneuve d’Ascq, France), June 1973, Editions du CNRS, Paris.

    Google Scholar 

  • Montreuil, J., 1975, Recent data on the structure of the carbohydrate moiety of glycoproteins—Metabolic and biological implications, Pure Appl. Chem. 42: 431.

    Article  CAS  Google Scholar 

  • Morgan, I. G., 1976, Synaptosomes and cell separation, Neuroscience 1: 159.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, I. G., and Gombos, G., 1976, Biochemical studies of synaptic macromolecules, in: Neuronal Recognition ( S. Barondes, ed.), pp. 179–202, Plenum Press, New York.

    Google Scholar 

  • Morgan, I. G., Gombos, G., and Tettamanti, G., 1977, Glycoproteins and glycolipids of the nervous system, in: The Glycoconjugates, Vol. 1 ( M. I. Horowitz and W. Pigman, eds.), pp. 351–383, Academic Press, New York.

    Google Scholar 

  • Oldberg, A., Hook, M., Obrink, B., Pertoft, H., and Rubin, K., 1977, Structure and metabolism of rat liver heparan sulphate, Biochem. J. 164: 75.

    PubMed  CAS  Google Scholar 

  • Quarles, R. H., and Brady, R. O., 1971, Synthesis of glycoproteins and gangliosides in developing rat brain, J. Neurochem. 18: 1809.

    Article  PubMed  CAS  Google Scholar 

  • Rauvala, H., 1976, The fucoganglioside of human kidney, FEBS Lett. 62: 161.

    Article  PubMed  CAS  Google Scholar 

  • Rauvala, H., and Karkkainen, J., 1977, Methylation analysis of neuraminic acids by gas chromatography-mass spectrometry, Carbohydr. Res. 56: 1.

    Article  PubMed  CAS  Google Scholar 

  • Saigo, K., and Egami, F., 1970, Purification and some properties of acid mucopolysaccharides of bovine brain, J. Neurochem. 17: 633.

    Article  PubMed  CAS  Google Scholar 

  • Simonian, S., Heijlman, J., and Hooghwinkel, G. J. M., 1978A, Studies on the low molecular weight glycoprotein GP-350: Molecular and immunological heterogeneity, J. Neurochem. 31:103.

    Article  CAS  Google Scholar 

  • Simonian, S., Heijlman, J., and Hooghwinkel, G. J. M., 19786, Carbohydrate composition of the soluble and membrane-bound GP-350 fractions, Scand. J. Immunol, (in press).

    Google Scholar 

  • Simpson, D. L., Thorne, D. R., and Loh, H. H., 1976, Sulfated glycoproteins, glycolipids and glycosaminoglycans from synaptic plasma and myelin membranes: Isolation and characterization of sulfated glycopeptides, Biochemistry 15: 5449.

    Article  PubMed  CAS  Google Scholar 

  • Singh, M., and Bachhawat, B. K., 1968, Isolation and characterization of glycosaminoglycans in human brain of different age groups, J. Neurochem. 15: 249.

    Article  CAS  Google Scholar 

  • Singh, M., Chandrasekaran, E. V., Cherian, R., and Bachhawat, B. K., 1969, Isolation and char-acterization of glycosaminoglycans in brain of different species, J. Neurochem. 16: 1157.

    Article  PubMed  CAS  Google Scholar 

  • Stadler, H., and Whittaker, V. P., 1978, Identification of vesiculin as a glycosaminoglycan. Brain Res. 153: 408.

    Article  PubMed  CAS  Google Scholar 

  • Tani, E., and Ametani, T., 1971, Extracellular distribution of ruthenium red positive substance in the cerebral cortex, J. Ultrastruct. Res. 34: 1.

    Article  PubMed  Google Scholar 

  • Tashiro, T., and Stadler, H., 1978, Chemical composition of cholinergic synaptic vesicles from Torpedo marmorata based on improved purification, Eur. J. Biochem. 90: 479.

    Article  PubMed  CAS  Google Scholar 

  • Toledo, O. M. S., and Dietrich, C. P., 1977, Tissue specific distribution of sulfated mucopolysaccharides in mammals, Biochim. Biophys. Acta 498: 114.

    Article  PubMed  CAS  Google Scholar 

  • Toole, B. P., 1976, Morphogenetic role of glycosaminoglycans in brain and other tissues, in: Neuronal Recognition ( S. Barondes, ed.), pp. 275–329, Plenum Press, New York.

    Google Scholar 

  • Tsay, G. C., Dawson, G., and Sung, S.-S. J., 1976, Structure of the accumulating oligosaccharide in fucosidosis, J. Biol. Chem. 251: 5852.

    PubMed  CAS  Google Scholar 

  • Underhill, C. B., and Keller, J. M., 1977, Heparan sulfates of mouse cells: Analysis of parent and transformed 3T3 cell lines, Cell. Physiol. 90: 53.

    Article  CAS  Google Scholar 

  • Van den Eijnden, D. H., 1973, The subcellular localization of cytidine 5′-monophospho-./V- acetylneuraminic acid synthetase in calf brain, J. Neurochem. 21: 949.

    Article  PubMed  Google Scholar 

  • Van Nieuw Amerongen, A., and Roukema, P. A., 1973, Physico-chemical characteristics and regional distribution studies of GP-350, a soluble sialoglycoprotein from brain, J. Neurochem. 21: 125.

    Article  PubMed  Google Scholar 

  • Van Nieuw Amerongen, A., and Roukema, P.A., 1974, GP-350, a sialoglycoprotein from calf brain: Its subcellular localization and occurrence in various brain areas, J. Neurochem. 23: 85.

    Article  PubMed  Google Scholar 

  • Van Nieuw Amerongen, A., Van den Eijnden, D. H., Heijlman, J., and Roukema, P. A., 1972, Isolation and characterization of a soluble glucose-containing sialoglycoprotein from the cortical grey matter of calf brain, J. Neurochem. 19: 2195.

    Article  PubMed  Google Scholar 

  • Van Nieuw Amerongen, A., Roukema, P. A., and Van Rossum, A. L., 1974, Immunofluorescence study on the cellular localization of GP-350, a sialoglycoprotein from brain, Brain Res. 81: 1.

    Article  Google Scholar 

  • Varma, R., Vercellotti, J. R., and Varma, R. S., 1977, On arabinose as a component of brain hyaluronate—Confirmation by chromatographic, enzymatic and chemical ionization-mass spectrometric analyses, Biochim. Biophys. Acta 497: 608.

    Article  PubMed  CAS  Google Scholar 

  • Vitello, L., Breen, M., Weinstein, H. G., Sittig, R. A., and Blacik, L. J., 1978, Keratan sulfate- like glycosaminoglycan in the cerebral cortex of the brain and its variation with age, Biochim. Biophys. Acta 539: 305.

    Article  PubMed  CAS  Google Scholar 

  • Vos, J., Kuriyama, K., and Roberts, E., 1969, Distribution of acid mucopolysaccharides in subcellular fractions of mouse brain, Brain Res. 12: 172.

    Article  PubMed  CAS  Google Scholar 

  • Warecka, K., Moller, H. J.,Vogel, H.-M., and Tripatzis, I., 1972, Human brain-specific alpha2- glycoprotein: Purification by affinity chromatography and detection of a new component; localization in nervous cells, J. Neurochem. 19: 719.

    CAS  Google Scholar 

  • Yang, H.-J., and Hakomori, S.-I., 1971, A sphingolipid having a novel type of ceramide and lacto-jV-fucopentaose III, J. Biol. Chem. 246: 1192.

    PubMed  CAS  Google Scholar 

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  1. Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York, USA

    Renée K. Margolis

  2. Department of Pharmacology, New York University School of Medicine, New York, New York, USA

    Richard U. Margolis

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  1. New York University Medical Center, New York, New York, USA

    Richard U. Margolis

  2. Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Renée K. Margolis

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Margolis, R.K., Margolis, R.U. (1979). Structure and Distribution of Glycoproteins and Glycosaminoglycans. In: Margolis, R.U., Margolis, R.K. (eds) Complex Carbohydrates of Nervous Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2925-1_3

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