Abstract
The influence of nutritional intake and nutritional status on the activity of tissue proteases has been the subject of research for many years. In general, two different aspects of this subject have been investigated: 1) The effects of protein malnutrition, calorie malnutrition and proteincalorie malnutrition on protease activity and the contribution of proteases to wasting in starvation; and 2) The effect of specific nutrient deficiencies on specific proteases. This manuscript will briefly review these two areas of research.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
N.H. Munro, and M.C. Crim, The proteins and amino acids, in: Modern Nutrition in Health and Disease, 7th Edition, M.E.Shils, V.R.Young (eds.), Lea & Febiger, Philadelphia, pp. 1 (1988).
L.J. Hoffer, Starvation, in: Modern Nutrition in Health and Disease, 7th Edition, M.E.Shils, V.R.Young, Lea & Febiger, Philadelphia, pp. 774 (1988).
G.F. Cahill Jr., Starvation in man, N. Engl. J. Med. 282: 668 (1970).
P. Felig, O.E. Owen, J. Wahren, and G.F. Cahill Jr., Amino acid metabolism during prolonged starvation, J. Clin. Invest. 48: 584 (1969).
D.J. Millward, and J.C. Waterlow, Effect of nutrition on protein turnover in skeletal muscle, Federation Proc. 37: 2283 (1978).
D.J. Millward, The effect of diet on proteolytic activity in rat skeletal muscle, Proc. Nutr. Soc. 31: 3A (1972).
S. Rosochacki, and D.J. Millward, Cathepsin D and acid autolytic activity in skeletal muscle of protein deficient, severely protein-energy restricted and refed rats. Proc. Nutr. Soc. 38(3): 137A (1979).
A. Roobol, and G.A.O. Alleyne, Changes in lysosomal hydrolase activity associated with malnutrition in young rats. Br. J. Nutr. 32: 189 (1974).
K. Wildenthal, A.R. Poole, A.M Glauert, and J.T. Dingle, Dietary Control of cardiac lysosomal enzyme activities. Recent Adv. Studies Cardiac Struct. Metab. 8: 519 (1975).
I.D. Desai, Regulation of lysosomal enzymes. I. Adaptive changes in enzyme activities during starvation and refeeding. Can. J. Biochem. 47: 785 (1969).
A.M. Samarel, E.A. Ogunro, A.G. Ferguson, P. Allenby, and M. Lesch, Rabbit cardiac immunoreactive cathepsin D content during starvationinduced atrophy. Am. J. Physiol. 240: H222 (1981).
A.L.N. Smith, Effects of starvation on vacuolar apparatus of cardiac muscle tissue determined by electron microscopy, marker-enzyme assays and electrolyte studies. Cytobios 18: 111 (1977).
R.S. Decker, J.S. Crie, A.R. Poole, J.T. Dingle, and K. Wildenthal, Resistance to ischemic damage in hearts of starved rabbits - Relation with lysosomal alterations and delayed release of cathepsin D. Lab. Invest. 43: 197 (1980).
A.L. Goldberg, The regulation of protein turnover by endocrine and nutritional factors, in: Plasticity of Muscle, D. Pette (ed.), Walter de Gruyter & Co., Berlin, p. 469 (1980).
M.D. Thompson, and H.C. Trowell, Pancreatic enzyme activity in duodenal contents of children with a type of kwashiorkor, The Lancet 1: 1031 (1952).
F. Gomez, R.R. Galvan, J. Cravioto, and S. Frenk, Studies on the undernourished child - Enzymatic activity of the duodenal contents in children affected with third degree malnutrition. Pediatrics 13: 548 (1954).
G.O. Barbezat, and J.D.L. Hansen, The exocrine pancreas and proteincalorie malnutrition, Pediatrics 42: 77 (1968).
J.N.P. Davies, The essential pathology of kwashiorkor. The Lancet 1 : 317 (1948).
K. Gyr, R.H. Wolf, A.R. Imodi, and O. Felsenfeld, Exocrine pancreatic function in protein-deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test. Gastroenterology 68: 488 (1975).
W.L. Seng, J.A. Glogowski, G. Wolf, M.B. Berman, K.R. Kenyon, and T.C. Kiorpes, The effect of thermal burns on the release of collagenase from corneas of vitamin A-deficient and control rats, Invest. Ophthalmol. Vis. Sci. 19: 1461 (1980).
M.C. Leonard, L.K. Maddison, and A. Pirie, A comparison between the enzymes in the cornea of the vitamin-A deficient rat and those of rat leukocytes, Exp. Eye Res. 33: 479 (1981).
S.S. Twining, D.L. Hatchell, R.A. Hyndiuk, and K.F. Nassif, Acid proteases and histologic correlations in experimental ulceration in vitamin a deficient rabbit corneas. Invest. Ophthalmol. Vis. Sci. 26: 31 (1985).
W.L. Seng, K.R. Kenyon, and G.Wolf, Studies on the source and release of collagenase in thermally burned corneas of vitamin A-deficient and control rats. Invest. Ophthalmol. Vis. Sci. 22: 62 (1982).
I.M. Weinstock, A.D. Goldrich, and A.T. Milhorat, Enzyme studies in muscular dystrophy. I. Muscle proteolytic activity and vitamin E-deficiency. Proc. Soc. Exptl. Biol. Med. 88: 257 (1955).
T.R. Koszalka, K.E. Mason, and G. Krol, Relation of vitamin E to proteolytic and autolytic activity of skeletal muscle. J. Nutr. 73: 78 (1961).
A.M Spanier, and J.W.C. Bird, Endogenous cathepsin B inhibitor activity in normal and myopathic red and white skeletal muscle, Muscle & Nerve 5: 313 (1982).
H. Zalkin, A.L. Tappel, K.A. Caldwell, S. Shibko, I.D. Desai, and T.A. Holliday, Increased lysosomal enzymes in muscular dystrophy of vitamin E-deficient rabbits. J. Biol. Chem. 237: 2678 (1962).
D.D. Dean, O.E. Muniz, I. Berman, J.C. Pita, M.R. Carreno, J.F. Woessner Jr., and D.S. Howell, Localization of collagenase in the growth plate of rachitic rats. J. Clin. Invest. 76: 716 (1985).
M. Das, and R.L. Soffer, Pulmonary angiotensin-converting enzyme. Structural and catalytic properties. J. Biol. Chem. 250: 6762 (1975).
P.G. Reeves, and B.L. O’Dell, An experimental study of the effect of zinc on the activity of angiotensin converting enzyme in serum. Clin. Chem. 31: 581 (1985).
L.P. Dornfeld, M.H. Maxwell, A. Waks, and M. Tuck, Mechnanisms of hypertension in obesity, Kidney Int. 32 (Suppl.22): S254 (1987).
M.L. Tuck, J. Sowers, L.P. Dornfeld, G. Kledzik and M.H. Maxwell, The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients, N. Engl. J. Med. 304: 930 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this paper
Cite this paper
Kopple, J.D. (1988). Nutrition and Protease Activity. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_50
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1057-0_50
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8313-3
Online ISBN: 978-1-4613-1057-0
eBook Packages: Springer Book Archive