Skip to main content

Nutrition and Protease Activity

  • Conference paper
Proteases II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 240))

Abstract

The influence of nutritional intake and nutritional status on the activity of tissue proteases has been the subject of research for many years. In general, two different aspects of this subject have been investigated: 1) The effects of protein malnutrition, calorie malnutrition and proteincalorie malnutrition on protease activity and the contribution of proteases to wasting in starvation; and 2) The effect of specific nutrient deficiencies on specific proteases. This manuscript will briefly review these two areas of research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. N.H. Munro, and M.C. Crim, The proteins and amino acids, in: Modern Nutrition in Health and Disease, 7th Edition, M.E.Shils, V.R.Young (eds.), Lea & Febiger, Philadelphia, pp. 1 (1988).

    Google Scholar 

  2. L.J. Hoffer, Starvation, in: Modern Nutrition in Health and Disease, 7th Edition, M.E.Shils, V.R.Young, Lea & Febiger, Philadelphia, pp. 774 (1988).

    Google Scholar 

  3. G.F. Cahill Jr., Starvation in man, N. Engl. J. Med. 282: 668 (1970).

    Article  PubMed  CAS  Google Scholar 

  4. P. Felig, O.E. Owen, J. Wahren, and G.F. Cahill Jr., Amino acid metabolism during prolonged starvation, J. Clin. Invest. 48: 584 (1969).

    Article  PubMed  CAS  Google Scholar 

  5. D.J. Millward, and J.C. Waterlow, Effect of nutrition on protein turnover in skeletal muscle, Federation Proc. 37: 2283 (1978).

    CAS  Google Scholar 

  6. D.J. Millward, The effect of diet on proteolytic activity in rat skeletal muscle, Proc. Nutr. Soc. 31: 3A (1972).

    Article  Google Scholar 

  7. S. Rosochacki, and D.J. Millward, Cathepsin D and acid autolytic activity in skeletal muscle of protein deficient, severely protein-energy restricted and refed rats. Proc. Nutr. Soc. 38(3): 137A (1979).

    Google Scholar 

  8. A. Roobol, and G.A.O. Alleyne, Changes in lysosomal hydrolase activity associated with malnutrition in young rats. Br. J. Nutr. 32: 189 (1974).

    Article  PubMed  CAS  Google Scholar 

  9. K. Wildenthal, A.R. Poole, A.M Glauert, and J.T. Dingle, Dietary Control of cardiac lysosomal enzyme activities. Recent Adv. Studies Cardiac Struct. Metab. 8: 519 (1975).

    CAS  Google Scholar 

  10. I.D. Desai, Regulation of lysosomal enzymes. I. Adaptive changes in enzyme activities during starvation and refeeding. Can. J. Biochem. 47: 785 (1969).

    PubMed  CAS  Google Scholar 

  11. A.M. Samarel, E.A. Ogunro, A.G. Ferguson, P. Allenby, and M. Lesch, Rabbit cardiac immunoreactive cathepsin D content during starvationinduced atrophy. Am. J. Physiol. 240: H222 (1981).

    Google Scholar 

  12. A.L.N. Smith, Effects of starvation on vacuolar apparatus of cardiac muscle tissue determined by electron microscopy, marker-enzyme assays and electrolyte studies. Cytobios 18: 111 (1977).

    PubMed  CAS  Google Scholar 

  13. R.S. Decker, J.S. Crie, A.R. Poole, J.T. Dingle, and K. Wildenthal, Resistance to ischemic damage in hearts of starved rabbits - Relation with lysosomal alterations and delayed release of cathepsin D. Lab. Invest. 43: 197 (1980).

    PubMed  CAS  Google Scholar 

  14. A.L. Goldberg, The regulation of protein turnover by endocrine and nutritional factors, in: Plasticity of Muscle, D. Pette (ed.), Walter de Gruyter & Co., Berlin, p. 469 (1980).

    Google Scholar 

  15. M.D. Thompson, and H.C. Trowell, Pancreatic enzyme activity in duodenal contents of children with a type of kwashiorkor, The Lancet 1: 1031 (1952).

    Article  CAS  Google Scholar 

  16. F. Gomez, R.R. Galvan, J. Cravioto, and S. Frenk, Studies on the undernourished child - Enzymatic activity of the duodenal contents in children affected with third degree malnutrition. Pediatrics 13: 548 (1954).

    Google Scholar 

  17. G.O. Barbezat, and J.D.L. Hansen, The exocrine pancreas and proteincalorie malnutrition, Pediatrics 42: 77 (1968).

    PubMed  CAS  Google Scholar 

  18. J.N.P. Davies, The essential pathology of kwashiorkor. The Lancet 1 : 317 (1948).

    Article  CAS  Google Scholar 

  19. K. Gyr, R.H. Wolf, A.R. Imodi, and O. Felsenfeld, Exocrine pancreatic function in protein-deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test. Gastroenterology 68: 488 (1975).

    PubMed  CAS  Google Scholar 

  20. W.L. Seng, J.A. Glogowski, G. Wolf, M.B. Berman, K.R. Kenyon, and T.C. Kiorpes, The effect of thermal burns on the release of collagenase from corneas of vitamin A-deficient and control rats, Invest. Ophthalmol. Vis. Sci. 19: 1461 (1980).

    PubMed  CAS  Google Scholar 

  21. M.C. Leonard, L.K. Maddison, and A. Pirie, A comparison between the enzymes in the cornea of the vitamin-A deficient rat and those of rat leukocytes, Exp. Eye Res. 33: 479 (1981).

    Article  PubMed  CAS  Google Scholar 

  22. S.S. Twining, D.L. Hatchell, R.A. Hyndiuk, and K.F. Nassif, Acid proteases and histologic correlations in experimental ulceration in vitamin a deficient rabbit corneas. Invest. Ophthalmol. Vis. Sci. 26: 31 (1985).

    PubMed  CAS  Google Scholar 

  23. W.L. Seng, K.R. Kenyon, and G.Wolf, Studies on the source and release of collagenase in thermally burned corneas of vitamin A-deficient and control rats. Invest. Ophthalmol. Vis. Sci. 22: 62 (1982).

    PubMed  CAS  Google Scholar 

  24. I.M. Weinstock, A.D. Goldrich, and A.T. Milhorat, Enzyme studies in muscular dystrophy. I. Muscle proteolytic activity and vitamin E-deficiency. Proc. Soc. Exptl. Biol. Med. 88: 257 (1955).

    CAS  Google Scholar 

  25. T.R. Koszalka, K.E. Mason, and G. Krol, Relation of vitamin E to proteolytic and autolytic activity of skeletal muscle. J. Nutr. 73: 78 (1961).

    CAS  Google Scholar 

  26. A.M Spanier, and J.W.C. Bird, Endogenous cathepsin B inhibitor activity in normal and myopathic red and white skeletal muscle, Muscle & Nerve 5: 313 (1982).

    Article  CAS  Google Scholar 

  27. H. Zalkin, A.L. Tappel, K.A. Caldwell, S. Shibko, I.D. Desai, and T.A. Holliday, Increased lysosomal enzymes in muscular dystrophy of vitamin E-deficient rabbits. J. Biol. Chem. 237: 2678 (1962).

    PubMed  CAS  Google Scholar 

  28. D.D. Dean, O.E. Muniz, I. Berman, J.C. Pita, M.R. Carreno, J.F. Woessner Jr., and D.S. Howell, Localization of collagenase in the growth plate of rachitic rats. J. Clin. Invest. 76: 716 (1985).

    Article  PubMed  CAS  Google Scholar 

  29. M. Das, and R.L. Soffer, Pulmonary angiotensin-converting enzyme. Structural and catalytic properties. J. Biol. Chem. 250: 6762 (1975).

    PubMed  CAS  Google Scholar 

  30. P.G. Reeves, and B.L. O’Dell, An experimental study of the effect of zinc on the activity of angiotensin converting enzyme in serum. Clin. Chem. 31: 581 (1985).

    PubMed  CAS  Google Scholar 

  31. L.P. Dornfeld, M.H. Maxwell, A. Waks, and M. Tuck, Mechnanisms of hypertension in obesity, Kidney Int. 32 (Suppl.22): S254 (1987).

    Google Scholar 

  32. M.L. Tuck, J. Sowers, L.P. Dornfeld, G. Kledzik and M.H. Maxwell, The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients, N. Engl. J. Med. 304: 930 (1981).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this paper

Cite this paper

Kopple, J.D. (1988). Nutrition and Protease Activity. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_50

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1057-0_50

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8313-3

  • Online ISBN: 978-1-4613-1057-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics