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Humoral Factors in Graves’ Ophthalmopathy

  • Chapter
Thyroid Autoimmunity

Abstract

The existence of specific receptors for thyrotropin (TSH) has been demonstrated in non-thyroidal cells such as fat cells of different animal species (1–5), as well as in retro-orbital tissue and lymphocytes (6), in fibroblasts, mouse L-cells, and neural membranes (7–10), in testicular and adrenal cells (11), and even in bacteria (12). It has been also demonstrated that TSH can exert a biological activity in fat cells (13–15) and this possibility lead many investigators to speculate whether Graves’ ophthalmopathy could reflect an autoimmune reaction involving shared orbital and thyroid antigens (16–18).

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Author information

Authors and Affiliations

  1. Clinica Medica III, Universita’ di Firenze, Firenze, Italy

    Roberto Toccafondi, Carlo M. Rotella, Roberto Zonefrati & Annalisa Tanini

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  1. Roberto Toccafondi
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  2. Carlo M. Rotella
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  3. Roberto Zonefrati
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  4. Annalisa Tanini
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Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    A. Pinchera  & G. F. Fenzi  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    S. H. Ingbar

  3. University of Miami, Miami, Florida, USA

    J. M. McKenzie

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© 1987 Plenum Press, New York

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Toccafondi, R., Rotella, C.M., Zonefrati, R., Tanini, A. (1987). Humoral Factors in Graves’ Ophthalmopathy. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0945-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8258-7

  • Online ISBN: 978-1-4613-0945-1

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