Thyroid Autoimmunity

1. Front Matter

   Pages i-xvi

   PDF

2. Graves’ Disease a Paradigm For Autoimmunity

   • D. D. Adams, A. Knight, J. G. Knight, P. Laing

   Pages 1-10

3. Nature of Thyroid Autoantigens: The TSH Receptor

   • John Chan, Michele De Luca, Pilar Santisteban, Osamu Isozaki, Sid Shifrin, Salvatore M. Aloj et al.

   Pages 11-26

4. Progress in Understanding the Thyroid Microsomal Antigen

   • Leslie J. Degroot, Luc Portmann, Noboru Hamada

   Pages 27-34

5. A Possible Role of Bacterial Antigens in the Pathogenesis of Autoimmune Thyroid Disease

   • Sidney H. Ingbar, Mordechai Weiss, Gary W. Cushing, Dennis L. Kasper

   Pages 35-44

6. “ATRA 1”: a New Autoantigen in Autoimmune Thyroid Disease

   • B. Rapoport, H. Hirayu, P. Seto, R. P. Magnusson, S. Filetti

   Pages 45-52

7. Monoclonal Antibodies in the Study of Thyriod Autoantigens and Autoantibodies

   • J. Ruf, B. Czarnocka, M. E. Toubert, C. Alquier, C. De Micco, M. Henry et al.

   Pages 53-62

8. Lats/Tsab: Then And Now

   • J. M. McKenzie

   Pages 63-68

9. Pathogenic Roles of TSH-Receptor Antibodies in Graves’ Disease

   • Shigenobu Nagataki

   Pages 69-76

10. Physiopathological Relevance of Thyroid Stimulating Antibody (TSAb) Measurements in Graves’ Disease

    • Jacques Orgiazzi, Anne-Marie Madec, Rene Mornex

    Pages 77-82

11. TSH Receptor Autoantibodies Affecting Thyroid Cell Function

    • G. F. Fenzi, P. Vitti, C. Marcocci, L. Chiovato, E. Macchia

    Pages 83-90

12. Heterogeneity of TSH Receptor-directed Antibodies (TRAb) and Their Significance

    • Margita Zakarija

    Pages 91-98

13. Humoral Factors in Graves’ Ophthalmopathy

    • Roberto Toccafondi, Carlo M. Rotella, Roberto Zonefrati, Annalisa Tanini

    Pages 99-108

14. Immunoregulatory Abnormalities in Autoimmune Thyroid Disease

    • Robert Volpé, Vas V. Row

    Pages 109-115

15. Intrathyroidal Lymphocytes, Thyroid Autoantibodies and Thyroid Destruction

    • S. M. McLachlan, C. A. S. Pegg, M. C. Atherton, S. Middleton, P. Rooke, C. Thompson et al.

    Pages 117-124

16. Cellular Mechanism for Autoimmune Damage in Thyroid-Associated Ophthalmopathy

    • J. How, Y. Hiromatsu, P. Wang, M. Salvi, J. R. Wall

    Pages 125-133

17. Thyroid Infiltrating T Lymphocytes in Hashimoto’s Thyroiditis: Phenotypic and Functional Analysis at Single Cell Level

    • G. F. Del Prete, A. Tiri, S. Mariotti, A. Pinchera, S. Romagnani, M. Ricci

    Pages 135-144

18. An In Vitro Model for Thyroid Autoimmunity

    • B. E. Wenzel, R. Gutekunst, S. Grammerstorf, P. C. Scriba

    Pages 145-152

19. Genetic Aspects Of Graves’disease

    • A. M. McGregor, S. Ratanachaiyavong, C. Gunn, K. W. Lee, P. S. Barnett, C. Darke et al.

    Pages 153-158

20. Thyroid and Related Autoimmune Disorders: Challenging the Dogmas

    • Gian Franco Bottazzo, Ian Todd, Antonino Belfiore Rita Mirakian, Ricardo Pujol-Borrell

    Pages 159-173

In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.

• autoimmune disease
• autoimmunity
• diseases
• immunity
• pathogenesis

• University of Pisa, Pisa, Italy

  A. Pinchera, G. F. Fenzi

• Harvard Medical School, Boston, USA

  S. H. Ingbar

• University of Miami, Miami, USA

  J. M. McKenzie

Policies and ethics