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An Essay on Biological Degradation of Collagen

  • Chapter
Cell Biology of Extracellular Matrix

Abstract

The limitations of language very often tend to confuse concepts. We are intuitively led to believe that the cleavage of a molecule is a “degradative” or catabolic activity. However, enzymatic removal of portions of molecules serves the purpose of activating them if they are enzymes or altering their behavior so that they may now form a highly ordered superstructure, as in the case of the fibrinogen—fibrin conversion or procollagen—collagen transformation in fibril-logenesis. The inactive precursor molecules are “degraded” to shorter sizes that permit their participation in the process for which they were designed. In the case of morphogenesis at the tissue level, total destruction of the extensive collagenous lamellae of the tadpole tail during metamorphosis involves highly synchronized and selective removal of collagen fibrils, the function of this process being to prepare the animal for its transition from an aqueous to a terrestrial environment. On another level during embryonic development, highly localized and in some cases massive programmed death of cells is an important phase of morphogenesis (e.g., limbs and nervous system). From the viewpoint of the dismantled structural or cellular element, it is undergoing degradation, but viewed from the higher level of the tissue or the organism as a whole, the process is merely a phase of essential remodeling to facilitate overall function.

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  1. The Developmental Biology Laboratory, Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA

    Jerome Gross

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  1. Department of Anatomy, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Elizabeth D. Hay

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© 1981 Plenum Press, New York

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Gross, J. (1981). An Essay on Biological Degradation of Collagen. In: Hay, E.D. (eds) Cell Biology of Extracellular Matrix. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0881-2_9

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  • DOI: https://doi.org/10.1007/978-1-4613-0881-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8226-6

  • Online ISBN: 978-1-4613-0881-2

  • eBook Packages: Springer Book Archive

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