Cell Biology of Extracellular Matrix

1. Front Matter

   Pages i-xvii

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2. Introductory Remarks

   1. Introductory Remarks

      • Elizabeth D. Hay

      Pages 1-4

3. What is Extracellular Matrix?

   1. Collagen

      • T. F. Linsenmayer

      Pages 5-37

   2. Proteoglycans

      • Vincent C. Hascall, Gretchen K. Hascall

      Pages 39-63

   3. Elastin

      • Carl Franzblau, Barbara Faris

      Pages 65-93

   4. Fibronectin and Other Structural Proteins

      • Kenneth M. Yamada

      Pages 95-114

4. How Do Cells Produce the Matrix?

   1. Proteoglycan Biosynthesis

      • Albert Dorfman

      Pages 115-138

   2. Collagen Biosynthesis

      • Bjorn Reino Olsen

      Pages 139-177

   3. Matrix Assembly

      • Robert L. Trelstad, Frederick H. Silver

      Pages 179-215

   4. An Essay on Biological Degradation of Collagen

      • Jerome Gross

      Pages 217-258

5. What Does Matrix Do for Cells?

   1. Glycosaminoglycans in Morphogenesis

      • Bryan P. Toole

      Pages 259-294

   2. Fibronectin and Its Relation to Cellular Structure and Behavior

      • Richard O. Hynes

      Pages 295-334

   3. The Glomerular Basement Membrane

      • Marilyn Gist Farquhar

      Pages 335-378

   4. Collagen and Embryonic Development

      • Elizabeth D. Hay

      Pages 379-409

6. Back Matter

   Pages 411-417

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At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears. After all, the matrix is EXTRAcellular, outside the cells. In this book, however, the authors make a compelling case for the relevance of the matrix to cellular concerns. Not only are numerous cell types, including many epithelia, quite caught up in the business of manufacturing matrix components, but also most of them contain matrix molecules in exoskeletons that are attached to the plasmalemma and that organize or otherwise influence the affairs of the cyto­ plasm. The idea of this book is to present the extracellular matrix to cell biolo­ gists of all levels. The authors are active and busy investigators, recognized experts in their fields, but all were enthusiastic about the prospect of writing for this audience. The chapters are not "review" articles in the usual sense, nor are they rehashes of symposium talks; they were written specifically for this book and they present the "state of the art" in engaging style, with ample references to more technical or historical reviews. The book is rich in electron micro­ graphs and diagrams and for many of the latter, as well as for the design of the cover, we are indebted to Sylvia J. Keene, medical illustrator for the Department of Anatomy at Harvard Medical Scrool. We also owe special thanks to Susan G.

• biology
• cell
• cell biology
• influence

• Department of Anatomy, Harvard Medical School, Boston, USA

  Elizabeth D. Hay

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