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Characterization of Lamina I Projection Neurons: Physiology and Anatomy

  • Chapter
Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord

Abstract

The primary afferent input to the most superficial part of the dorsal horn has been shown to originate from slowly conducting (Aδ and C) fibers. Recordings from individual slowly conducting myelinated (Burgess and Perl, 1967; Perl, 1968) and unmyelinated (Bessou and Perl, 1969; Beitel and Dubner, 1976; Kumazawa and Perl, 1977) fibers demonstrated that a large proportion of these small fibers required high threshold cutaneous stimulation for their activation and could be classified as various types of nociceptors. Thus, it follows that regions in which small diameter afferents terminate play a role in pain mechanisms. Christensen and Perl (1970), in a study designed specifically to discover cells responding to high-threshold mechanoreceptors, found a concentration of such cells in the marginal zone (lamina I) of the cat. Their report concluded that lamina I represents a specialized sensory nucleus containing neurons important for nociception and for detection of thermal changes in the skin (Christensen and Perl, 1970). Although some lamina I neurons appear to receive primary afferent input exclusively from nociceptors, others receive convergent input from a variety of peripheral receptors (Willis et al, 1974; Price and Browe, 1975; Cervero et al, 1976 Price et al 1976).

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Authors and Affiliations

  1. Neurobiology and Anesthesiology Branch, National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, 20892, USA

    Janice L. K. Hylden, Richard L. Nahin, Fernand Anton & Ronald Dubner

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  4. Ronald Dubner
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Editors and Affiliations

  1. University of Bristol Medical School, Bristol, UK

    F. Cervero

  2. National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, USA

    G. J. Bennett

  3. University of Bristol Medical School, Bristol, UK

    P. M. Headley

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© 1989 Plenum Press, New York

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Hylden, J.L.K., Nahin, R.L., Anton, F., Dubner, R. (1989). Characterization of Lamina I Projection Neurons: Physiology and Anatomy. In: Cervero, F., Bennett, G.J., Headley, P.M. (eds) Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0825-6_15

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  • DOI: https://doi.org/10.1007/978-1-4613-0825-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8101-6

  • Online ISBN: 978-1-4613-0825-6

  • eBook Packages: Springer Book Archive

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