Abstract
The mechanisms of evolution of RNA virus genomes have recently received less attention than the evolution of DNA genomes (or of RNA retroviruses able to reverse-transcribe their RNA genomes into DNA proviruses). The latter two virus groups can employ all of the myriad mutational and recombinational mechanisms of DNA evolution, which have been intensively investigated during the past decade. On the other hand the genomes of “ordinary,” nonretrovirus RNA viruses rarely, if ever, are reverse-copied into DNA, so they can neither integrate onto host chromosomes, nor recombine or transpose with other DNA elements. Yet the earlier studies of RNA virus genetics [1] showed that they are extremely mutable. The author and his colleagues recently published an extensive review of the literature documenting that RNA viruses not only exhibit very high mutation rates, but that their genomes undergo extremely rapid rates of evolution [2]. Space limitations prevent referencing herein most of the numerous studies upon which these conclusions are based, but the reader can obtain these from the above review.
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References
Granoff A (1961) Induction of Newcastle disease virus mutants. Virology 13:402–408
Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, VandePol S (1982) Rapid evolution of RNA genomes. Science 215:1577–1585
Drake JW (1969) Comparative rates of spontaneous mutation. Nature 221:1132
Morley AA, Trainor KJ, Seshadri R, Ryall R (1983) Measurement of in vivo mutations in human lymphocytes. Nature 302:155–156
Domingo E, Sabo D, Taniguchi T, Weissmann C (1978) Nucleotide sequence heterogeneity of an RNA phage population. Cell 13:735–744
Pringle CR (1982) The genetics of vesiculoviruses. Arch Virol 72:1–34
Clewley JP, Bishop DHL, Kang CY, Coffin J, Schitzlein WM, Reichmann ME (1977) Oligonucleotide fingerprints of RNA species obtained from rhabdoviruses belonging to the vesicular stomatitis virus subgroup. J Virol 23:152–166
Kew OM, Nottay BK, Hatch MH, Nakano JH, Obijeski JF (1981) Multiple genetic changes can occur in the oral poliovaccines upon replication in humans. J Gen Virol 56:337–347
Spindler KR, Horodyski FM, Holland JJ (1982) High multiplicities of infection favor rapid and random evolution of vesicular stomatitis virus. Virology 119:98–108
King AMQ, McCahon D, Slade WR, Newman JWI (1982) Recombination in RNA. Cell 29:921–928
Tolskaya EA, Ramonova LA, Kolensnikova MS, Agol VI (1983) Intertypic recombination in poliovirus: Genetic and biochemical studies. Virology 124:121–132
Fields S, Winter G (1982) Nucleotide sequences of influenza virus segments 1 and 3 reveal mosaic structure of a small virus RNA segment. Cell 28:303–313
Horodyski FM, Nichol ST, Sprindler KR, Holland JJ (1983) Properties of DI particle-resistant mutants of vesicular stomatitis virus isolated from persistent infections and from undiluted passages. Cell 33:801–810
O’Hara PJ, Horodyski FM, Nichol ST, Holland JJ (1984) Vesicular stomatitis virus mutants resistant to defective interfering particles accumulate stable 5′-terminal and fewer 3′-terminal mutations in a stepwise manner. J Virol 49:793–798
Pringle CR, Devine V, Wilkie M, Preston CM, Dolan A, McGeoch DJ (1981) Enhanced mutability associated with a temperature sensitive mutant of vesicular stomatitis virus. J Virol 39:377–389
Prabhakar BS, Hospel MW, McClintock PR, Notkins AL (1982) High frequency of antigenic variants among naturally occurring human Coxsackie B4 virus isolates identified by monoclonal antibodies. Nature 300:374–376
Printz P (1970) Adaptation du virus de la stomatite vésiculate à Drosophila melanogaster. Ann Inst Pasteur, Paris 119:520–537
Mudd JA, Leavitt RW, Kingsbury DT, Holland JJ (1973) Natural selection of mutants of vesicular stomatitis virus by cultured cells of Drosophila melanogaster. J Gen Virol 20:341–351
Jukes TH (1980) Silent nucleotide substitutions and the molecular evolutionary clock. Science 210:973–978
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© 1984 Springer-Verlag New York Inc.
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Holland, J.J. (1984). Continuum of Change in RNA Virus Genomes. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_20
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DOI: https://doi.org/10.1007/978-1-4612-5250-4_20
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