Concepts in Viral Pathogenesis

1. Front Matter

   Pages i-xviii

   PDF

2. Host Control of Viral Spread

   1. Front Matter

      Pages 1-2

      PDF

   2. Early Non-immune Control

      1. Interferon and Viral Pathogenesis

         • G. John Stanton, S. Baron

         Pages 3-10

      2. Natural Killer Cells in Viral Infection

         • Paolo Casali, Giorgio Trinchieri

         Pages 11-19

      3. The Role of the Complement System in Host Defense Against Virus Diseases

         • Neil R. Cooper

         Pages 20-25

      4. Proteolytic Cleavage and Virus Pathogenesis

         • Andreas Scheid, Purnell W. Choppin

         Pages 26-31

   3. Immune Control—Humoral

      1. Mechanisms of Virus Neutralization

         • Benjamin Mandel

         Pages 32-38

      2. Antibody- and Complement-Dependent Lysis of Virus-Infected Cells

         • J. G. P. Sissons

         Pages 39-45

   4. Immune Control—Cellular

      1. The Inflammatory Response to Acute Viral Infections

         • Diane E. Griffin

         Pages 46-52

      2. MHC Restriction and Cytotoxic T Lymphocytes

         • P. C. Doherty, R. M. Zinkernagel

         Pages 53-57

      3. Antibody-Dependent Cellular Cytotoxicity (ADCC) Mediated by Human Killer Lymphocytes (K-Cells)

         • Peter Perlmann

         Pages 58-64

      4. Cloning of Functional T Lymphocytes

         • Jean-Charles Cerottini, H. Robson MacDonald

         Pages 65-70

   5. Genetic Control

      1. Host Genes that Influence Susceptibility to Viral Diseases

         • Margo A. Brinton, Kenneth J. Blank, Neal Nathanson

         Pages 71-78

      2. Host Genes Controlling the Immune Response

         • Hugh O. McDevitt

         Pages 79-85

      3. On the Role of Recombinant Retroviruses in Murine Leukemia

         • John H. Elder

         Pages 86-93

3. Host Range and Tissue Tropism

   1. Front Matter

      Pages 95-95

      PDF

   2. Viral Receptors: Expression, Regulation and Relationship to Infectivity

      • Patrick R. McClintock, Abner Louis Notkins

      Pages 97-101

   3. Viral Genes and Tissue Tropism

      • Bernard N. Fields

      Pages 102-108

   4. Utilization of Host Proteins as Virus Receptors

      • Gregory H. Tignor, Abigail L. Smith, Robert E. Shope

      Pages 109-116

   5. Host Range and Tissue Tropisms: Antibody-Dependent Mechanisms

      • James S. Porterfield, M. Jane Cardosa

      Pages 117-122

The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil­ lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati­ cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read­ a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

• Antigen
• Hepatitis
• Immune System
• Interferon
• Monoclonal Antibodies
• Regulation
• Virus
• Viruses
• antiviral drug
• autoimmunity
• infection
• infections
• inflammatory response
• influence
• viral infection
• infectious diseases

• National Institutes of Health, Bethesda, USA

  Abner Louis Notkins

• Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, USA

  Michael B. A. Oldstone

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