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Analogy Between Endothelial/Mesangial Cell and Endothelial/Vascular Smooth Muscle Cell Interactions

Role of Growth Factors and Mechanotransduction

  • Chapter
Endocrinology of the Vasculature

Part of the book series: Contemporary Endocrinology ((COE,volume 1))

Abstract

There are many parallels between renal glomerular and vascular structure and function. Endothelial cells line both glomeruli and vessels, and mesangial cells are modified vascular smooth muscle cells (VSMC) (1-3). Endothelial and mesangial cells together account for about 85% of the total number of cells that make up the glomerulus (1 2), and these cells are distinguished by their biological characteristics and function (1-4). Both produce a variety of mitogens and cytokines known to have autocrine and paracrine activity. Their ability to produce growth factors is relevant given the anatomic relationship of the cells to each other. Anatomically, the glomerular basement membrane incompletely surrounds the endothelial wall, leaving an area of direct contact between the mesangial cells and the endothelium (2). This simulates the anatomical and functional relationship between endothelial cells and VSMC in the vasculature (3,4).

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Authors
  1. George L. Bakris MD
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  2. Paul R. Standley PhD
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  3. Carlos E. Palant MD
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  4. Mary F. Walsh PhD
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  5. James R. Sowers MD
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  1. School of Medicine, Wayne State University, Detroit, Michigan, USA

    James R. Sowers MD

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Bakris, G.L., Standley, P.R., Palant, C.E., Walsh, M.F., Sowers, J.R. (1996). Analogy Between Endothelial/Mesangial Cell and Endothelial/Vascular Smooth Muscle Cell Interactions. In: Sowers, J.R. (eds) Endocrinology of the Vasculature. Contemporary Endocrinology, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0231-8_24

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  • DOI: https://doi.org/10.1007/978-1-4612-0231-8_24

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