Abstract
This chapter addresses the complex relationship between sympathetic activity and the main factors affecting arterial distensibility. Sympathetic nervous system is considered one of the major elements involved in the regulation of mean arterial pressure, affecting heart rate, left ventricular contractility, and systemic vascular resistance. Actually, in hypertensive patients a permanent increase in mean arterial pressure may cause structural changes in viscoelastic properties of arterial wall, causing a permanent reduction in arterial distensibility. Moreover, heart rate, left ventricular function, and mean arterial pressure can also be considered major functional factors which can cause transient changes in arterial viscoelastic properties. Evidence is available that sympathetic activity plays a major role in modulating the mechanical properties of muscular arteries. This explains the reduction in distensibility of muscular arteries shown under particular conditions of stress, such as exposure to high altitude and, in general, to hypoxia. Changes in sympathetic activity may be influenced by baroreflex regulation of cardiovascular homeostasis. Reflex changes of arterial tone and modifications of cardiac output are the result of this regulation. A carotid and aortic stiffness may be associated with reduced cardiovagal baroreflex sensitivity, with a consequent increase in blood pressure variability, and also with a higher speed of changes in beat-to-beat systolic blood pressure fluctuations typical of hypertension.
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References
Salvi P. Pulse waves. How vascular hemodynamics affects blood pressure. Milan: Springer; 2012.
Lantelme P, Khettab F, Custaud MA, Rial MO, Joanny C, Gharib C, et al. Spontaneous baroreflex sensitivity: toward an ideal index of cardiovascular risk in hypertension? J Hypertens. 2002;20(5):935–44.
Lantelme P, Mestre C, Lievre M, Gressard A, Milon H. Heart rate: an important confounder of pulse wave velocity assessment. Hypertension. 2002;39(6):1083–7.
Albaladejo P, Copie X, Boutouyrie P, Laloux B, Declere AD, Smulyan H, et al. Heart rate, arterial stiffness, and wave reflections in paced patients. Hypertension. 2001;38(4):949–52.
Sa Cunha R, Pannier B, Benetos A, Siche JP, London GM, Mallion JM, et al. Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects. J Hypertens. 1997;15(12 Pt 1):1423–30.
Weissler AM, Harris WS, Schoenfeld CD. Systolic time intervals in heart failure in man. Circulation. 1968;37(2):149–59.
Campese VM, Shaohua Y, Huiquin Z. Oxidative stress mediates angiotensin II-dependent stimulation of sympathetic nerve activity. Hypertension. 2005;46(3):533–9.
Mircoli L, Mangoni AA, Giannattasio C, Mancia G, Ferrari AU. Heart rate-dependent stiffening of large arteries in intact and sympathectomized rats. Hypertension. 1999;34(4 Pt 1):598–602.
Mangoni AA, Mircoli L, Giannattasio C, Mancia G, Ferrari AU. Effect of sympathectomy on mechanical properties of common carotid and femoral arteries. Hypertension. 1997;30(5):1085–8.
Mangoni AA, Mircoli L, Giannattasio C, Ferrari AU, Mancia G. Heart rate-dependence of arterial distensibility in vivo. J Hypertens. 1996;14(7):897–901.
Armentano RL, Barra JG, Levenson J, Simon A, Pichel RH. Arterial wall mechanics in conscious dogs. Assessment of viscous, inertial, and elastic moduli to characterize aortic wall behavior. Circ Res. 1995;76(3):468–78.
Tan I, Butlin M, Liu YY, Ng K, Avolio AP. Heart rate dependence of aortic pulse wave velocity at different arterial pressures in rats. Hypertension. 2012;60(2):528–33.
Salvi P, Palombo C, Salvi GM, Labat C, Parati G, Benetos A. Left ventricular ejection time, not heart rate, is an independent correlate of aortic pulse wave velocity. J Appl Physiol. 2013;115(11):1610–7.
Boudoulas H. Systolic time intervals. Eur Heart J. 1990;11(Suppl I):93–104.
Reant P, Dijos M, Donal E, Mignot A, Ritter P, Bordachar P, et al. Systolic time intervals as simple echocardiographic parameters of left ventricular systolic performance: correlation with ejection fraction and longitudinal two-dimensional strain. Eur J Echocardiogr. 2010;11(10):834–44.
Boudoulas H, Karayannacos PE, Lewis RP, Leier CV, Vasko JS. Effect of afterload on left ventricular performance in experimental animals. Comparison of the pre-ejection period and other indices of left ventricular contractility. J Med. 1982;13(5–6):373–85.
Boutouyrie P, Lacolley P, Girerd X, Beck L, Safar M, Laurent S. Sympathetic activation decreases medium-sized arterial compliance in humans. Am J Physiol. 1994;267(4 Pt 2):H1368–76.
Giannattasio C, Mangoni AA, Stella ML, Carugo S, Grassi G, Mancia G. Acute effects of smoking on radial artery compliance in humans. J Hypertens. 1994;12(6):691–6.
Perret F, Mooser V, Waeber B, Yanik T, Jean-Jacques M, Mooser E, et al. Effect of cold pressor test on the internal diameter of the radial artery. Am J Hypertens. 1989;2(9):727–8.
Failla M, Grappiolo A, Emanuelli G, Vitale G, Fraschini N, Bigoni M, et al. Sympathetic tone restrains arterial distensibility of healthy and atherosclerotic subjects. J Hypertens. 1999;17(8):1117–23.
Grassi G, Giannattasio C, Failla M, Pesenti A, Peretti G, Marinoni E, et al. Sympathetic modulation of radial artery compliance in congestive heart failure. Hypertension. 1995;26(2):348–54.
Sonesson B, Vernersson E, Hansen F, Lanne T. Influence of sympathetic stimulation on the mechanical properties of the aorta in humans. Acta Physiol Scand. 1997;159(2):139–45.
Lydakis C, Momen A, Blaha C, Herr M, Leuenberger UA, Sinoway LI. Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure. Eur J Appl Physiol. 2008;102(6):633–41.
Palatini P, Julius S. The role of cardiac autonomic function in hypertension and cardiovascular disease. Curr Hypertens Rep. 2009;11(3):199–205.
Tentolouris N, Argyrakopoulou G, Katsilambros N. Perturbed autonomic nervous system function in metabolic syndrome. Neuromolecular Med. 2008;10(3):169–78.
Goodfellow J, Bellamy MF, Gorman ST, Brownlee M, Ramsey MW, Lewis MJ, et al. Endothelial function is impaired in fit young adults of low birth weight. Cardiovasc Res. 1998;40(3):600–6.
Leeson CP, Kattenhorn M, Morley R, Lucas A, Deanfield JE. Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation. 2001;103(9):1264–8.
Phipps K, Barker DJ, Hales CN, Fall CH, Osmond C, Clark PM. Fetal growth and impaired glucose tolerance in men and women. Diabetologia. 1993;36(3):225–8.
IJzerman R, Stehouwer CD, de Geus EJ, van Weissenbruch MM, Delemarre-van de Waal HA, Boomsma DI. Low birth weight is associated with increased sympathetic activity: dependence on genetic factors. Circulation. 2003;108(5):566–71.
Jansson T, Lambert GW. Effect of intrauterine growth restriction on blood pressure, glucose tolerance and sympathetic nervous system activity in the rat at 3-4 months of age. J Hypertens. 1999;17(9):1239–48.
Ruijtenbeek K, le Noble FA, Janssen GM, Kessels CG, Fazzi GE, Blanco CE, et al. Chronic hypoxia stimulates periarterial sympathetic nerve development in chicken embryo. Circulation. 2000;102(23):2892–7.
Westerbacka J, Vehkavaara S, Bergholm R, Wilkinson I, Cockcroft J, Yki-Jarvinen H. Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity. Diabetes. 1999;48(4):821–7.
Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR. Nitric oxide regulates local arterial distensibility in vivo. Circulation. 2002;105(2):213–7.
Phillips DI, Barker DJ. Association between low birthweight and high resting pulse in adult life: is the sympathetic nervous system involved in programming the insulin resistance syndrome? Diabet Med. 1997;14(8):673–7.
Salvi P, Revera M, Joly L, Reusz G, Iaia M, Benkhedda S, et al. Role of birth weight and postnatal growth on pulse wave velocity in teenagers. J Adolesc Health. 2012;51(4):373–9.
Richalet JP, Larmignat P, Rathat C, Keromes A, Baud P, Lhoste F. Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia. J Appl Physiol (1985). 1988;65(5)):1957–61.
Koller EA, Drechsel S, Hess T, Macherel P, Boutellier U. Effects of atropine and propranolol on the respiratory, circulatory, and ECG responses to high altitude in man. Eur J Appl Physiol Occup Physiol. 1988;57(2):163–72.
Marshall JM. Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev. 1994;74(3):543–94.
Salvi P, Revera M, Faini A, Giuliano A, Gregorini F, Agostoni P, et al. Changes in subendocardial viability ratio with acute high-altitude exposure and protective role of acetazolamide. Hypertension. 2013;61(4):793–9.
Bilo G, Caldara G, Styczkiewicz K, Revera M, Lombardi C, Giglio A, et al. Effects of selective and nonselective beta-blockade on 24-h ambulatory blood pressure under hypobaric hypoxia at altitude. J Hypertens. 2011;29(2):380–7.
Lanfranchi PA, Colombo R, Cremona G, Baderna P, Spagnolatti L, Mazzuero G, et al. Autonomic cardiovascular regulation in subjects with acute mountain sickness. Am J Physiol Heart Circ Physiol. 2005;289(6):H2364–72.
Parati G, Revera M, Giuliano A, Faini A, Bilo G, Gregorini F, et al. Effects of acetazolamide on central blood pressure, peripheral blood pressure, and arterial distensibility at acute high altitude exposure. Eur Heart J. 2013;34(10):759–66.
Bartsch P, Maggiorini M, Schobersberger W, Shaw S, Rascher W, Girard J, et al. Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness. J Appl Physiol (1985). 1991;71(1):136–43.
Mancia G, Mark A. Arterial baroreflexes in humans. In: Shepherd J, Abboud F, editors. Handbook of physiology, section 2. The cardiovascular system IV, vol. 3, Part 2. Bethesda: American Physiologic Society; 1983. p. 755–93.
Boutouyrie P. New techniques for assessing arterial stiffness. Diabetes Metab. 2008;34 Suppl 1:S21–6.
Mattace-Raso FU, van den Meiracker AH, Bos WJ, van der Cammen TJ, Westerhof BE, Elias-Smale S, et al. Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: the Rotterdam Study. J Hypertens. 2007;25(7):1421–6.
Parati G, Lantelme P. Mechanical and neural components of the cardiac baroreflex: new insights into complex physiology. J Hypertens. 2005;23(4):717–20.
Okada Y, Galbreath MM, Shibata S, Jarvis SS, VanGundy TB, Meier RL, et al. Relationship between sympathetic baroreflex sensitivity and arterial stiffness in elderly men and women. Hypertension. 2012;59(1):98–104.
Schillaci G, Bilo G, Pucci G, Laurent S, Macquin-Mavier I, Boutouyrie P, et al. Relationship between short-term blood pressure variability and large-artery stiffness in human hypertension: findings from 2 large databases. Hypertension. 2012;60(2):369–77.
Narkiewicz K, Winnicki M, Schroeder K, Phillips BG, Kato M, Cwalina E, et al. Relationship between muscle sympathetic nerve activity and diurnal blood pressure profile. Hypertension. 2002;39(1):168–72.
Parati G, Saul JP, Di Rienzo M, Mancia G. Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. A critical appraisal. Hypertension. 1995;25(6):1276–86.
Parati G, Ulian L, Santucciu C, Tortorici E, Villani A, Di Rienzo M, et al. Clinical value of blood pressure variability. Blood Press Suppl. 1997;2:91–6.
Parati G, Di Rienzo M, Omboni S, Ulian L, Mancia G. Blood pressure variability over 24 hours: its different components and its relationship to the arterial baroreflex. J Sleep Res. 1995;4(S1):21–9.
Monahan KD, Dinenno FA, Seals DR, Clevenger CM, Desouza CA, Tanaka H. Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol. 2001;281(1):H284–9.
Mancia G, Ferrari A, Gregorini L, Parati G, Pomidossi G, Bertinieri G, et al. Blood pressure and heart rate variabilities in normotensive and hypertensive human beings. Circ Res. 1983;53(1):96–104.
Mancia G, Parati G, Castiglioni P, Tordi R, Tortorici E, Glavina F, et al. Daily life blood pressure changes are steeper in hypertensive than in normotensive subjects. Hypertension. 2003;42(3):277–82.
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Parati, G., Salvi, P. (2014). Arterial Stiffness and the Sympathetic Nervous System. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_14
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