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Role of Nitric Oxide in Tumor Angiogenesis

  • Chapter
Angiogenesis in Brain Tumors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 117))

Abstract

Nitric oxide (NO) is an important signalling molecule that acts in many tissues to regulate different physiological and pathological processes. We have contributed to demonstrate that NO stimulates angiogenesis and mediates the effect of different angiogenic molecules. In human tumors NOS expression and activity correlate with tumor growth and aggressiveness, through angiogenesis stimulation and regulation of angiogenic factor expression. Drugs affecting the NOS pathway appear promising antitumor strategies by reducing edema, inhibiting angiogenesis and facilitating the delivery of chemotherapeutical agents.

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Authors and Affiliations

  1. Section of Pharmacology, Dept. Molecular Biology and C.R.1.S.M.A, University of Siena Pharmacy School, Via A. Moro 2, 53100, Siena, Italy

    Lucia Morbidelli, Sandra Donnini & Marina Ziche

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  1. Lucia Morbidelli
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  2. Sandra Donnini
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  3. Marina Ziche
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Editors and Affiliations

  1. Neurosurgery Carl Gustav Carus Hospital, Technical University of Dresden, Dresden, Germany

    Matthias Kirsch

  2. Neurosurgery Children’s Hospital Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Peter McL. Black

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Morbidelli, L., Donnini, S., Ziche, M. (2004). Role of Nitric Oxide in Tumor Angiogenesis. In: Kirsch, M., Black, P.M. (eds) Angiogenesis in Brain Tumors. Cancer Treatment and Research, vol 117. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8871-3_11

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  • DOI: https://doi.org/10.1007/978-1-4419-8871-3_11

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