Angiogenesis in Brain Tumors

  • Matthias Kirsch
  • Peter McL. Black

Part of the Cancer Treatment and Research book series (CTAR, volume 117)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Principles of Angiogenesis in the Central Nervous System

    1. Front Matter
      Pages 1-1
    2. Sybill Patan
      Pages 3-32
    3. Haymo Kurz, Johannes Korn, Bodo Christ
      Pages 33-50
  3. Assessment of Angiogenesis in Neuro-Oncology

    1. Front Matter
      Pages 77-77
    2. Ivan Radovanovic, Maria G. D’Angelo, Adriano Aguzzi
      Pages 97-114
    3. Roland H. Goldbrunner, Martin Bendszus, Jörg-Christian Tonn
      Pages 115-135
    4. Roland H. Goldbrunner, Martin Bendszus, Jörg-Christian Tonn
      Pages 137-138
    5. Roland H. Goldbrunner, Martin Bendszus, Jörg-Christian Tonn
      Pages 139-140
    6. Katrin Lamszus, Oliver Heese, Manfred Westphal
      Pages 141-146
    7. Lucia Morbidelli, Marina Ziche
      Pages 147-151
  4. Brain Tumor Related Angiogenesis

    1. Front Matter
      Pages 153-153
    2. Lucia Morbidelli, Sandra Donnini, Marina Ziche
      Pages 155-167
    3. Katrin Lamszus, Oliver Heese, Manfred Westphal
      Pages 169-190
    4. Marcia Regina Machein, Karl Heinz Plate
      Pages 191-218
    5. Peter Vajkoczy, Michael D. Menger
      Pages 249-262
    6. Lorenzo Bello, Carlo Giussani, Giorgio Carrabba, Mauro Pluderi, Francesco Costa, Andreas Bikfalvi
      Pages 263-284
    7. Matthias Kirsch, Gabriele Schackert, Peter McL. Black
      Pages 285-304
  5. Clinical Application in Neuro-Oncology

  6. Back Matter
    Pages 351-358

About this book


This volume "Angiogenesis in Brain Tumors" is part of the book series "Cancer Treatment and Research" and offers a detailed overview of the biology of angiogenesis in the central nervous system, the role of angiogenesis in brain tumor development and growth, and anti-angiogenic therapeutic applications. Our understanding of the mutual relationship between tumor growth and concomitant neovascularization has provided important insights into the biology of brain tumors and contributed to the development of new treatment strategies. Many of the early experimental findings on angiogenesis were made using brain tumor models. This was largely due to the fact that brain tumors are among the highest vascularized tumors. In addition, until to date all efforts to develop efficient therapies for these highly malignant tumors have met with little if any success . The scientific evidence on the role of angiogenesis in tumor development accumulated until today has already let to the initiation of several clinical trials. Despite the fact that not all expectations have been fulfilled, the results available so far are promising and suggest that anti­ angiogenic therapeutic strategies may be of benefit to our brain tumor patients in the near future. The volume is comprised of four sections . The first section is dedicated to the principles of angiogenesis in the central nervous system and gives an overview on the cellular, physiological and developmental processes of angiogenesis.


angiogenesis brain tumors cancer treatment clinical trial magnetic resonance imaging (MRI) metastasis tumor tumor growth

Editors and affiliations

  • Matthias Kirsch
    • 1
  • Peter McL. Black
    • 2
  1. 1.Neurosurgery Carl Gustav Carus HospitalTechnical University of DresdenDresdenGermany
  2. 2.Neurosurgery Children’s Hospital Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4699-9
  • Online ISBN 978-1-4419-8871-3
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site