Papillary thyroid carcinoma (PTC) is a malignant epithelial tumor showing follicular differentiation and distinctive nuclear features.1 Papillary thyroid carcinoma is the most common thyroid carcinoma, accounting for 80% of thyroid carcinomas.2 Numerous variants of PTC have been described, some of which behave more aggressively than conventional PTC. Three distinct molecular alterations are associated with PTC and are mutually exclusive.3 These include somatic BRAF point mutations, RET/PTC rearrangements, and somatic RAS point mutations. These molecular alterations are also associated with particular clinicopathologic features of PTC as well as particular subtypes of PTC.
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Erickson, L.A., Lloyd, R.V. (2010). Well-Differentiated Papillary Thyroid Carcinoma. In: Hunt, J. (eds) Molecular Pathology of Endocrine Diseases. Molecular Pathology Library, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1707-2_8
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Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-1706-5
Online ISBN: 978-1-4419-1707-2
eBook Packages: MedicineMedicine (R0)