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Role of NCAM in Emotion and Learning

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Structure and Function of the Neural Cell Adhesion Molecule NCAM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 663))

Abstract

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regulation - among other developmental functions - of neurite outgrowth and stabilization of synaptic connections. A large body of work has also demonstrated that NCAM is required in the adult brain for different behavioral functions. In this review, we focus on those studies that have shown a role of NCAM and PSA-NCAM in the regulation of emotional responses and in the learning and memory processes.

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Authors and Affiliations

  1. Laboratory of Behavioral Genetics, Brain and Mind Institute, Swiss Federal Institute of Technology (EPFL), 1015, Lausanne, Switzerland

    Lisa Conboy

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  1. Lisa Conboy
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  2. Reto Bisaz
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  3. Kamila Markram
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  4. Carmen Sandi
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Correspondence to Lisa Conboy .

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  1. Panum Institute, Dept. Regenerative Medicine, University of Copenhagen, Blegdamsvej 3C, Koebenhavn N, 2200, Denmark

    Vladimir Berezin

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Conboy, L., Bisaz, R., Markram, K., Sandi, C. (2010). Role of NCAM in Emotion and Learning. In: Berezin, V. (eds) Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology, vol 663. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1170-4_18

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