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Enzymatic Basis of Phase I and Phase II Drug Metabolism

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Enzyme- and Transporter-Based Drug-Drug Interactions

Abstract

Enzyme systems have evolved in humans to maintain cellular homeostasis and to facilitate the disposition of xenobiotics. These enzymes possess complementary, and sometimes overlapping, functions, a feature which can set the stage for drug–drug interactions. In this chapter, we provide an overview of the phase I and phase II families of detoxification enzymes, their potential for induction and inhibition, and the role of genetic variants in the occurrence of drug–drug interactions.

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Authors and Affiliations

  1. Department of Environmental and Occupational Health, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Susan Kadlubar

  2. Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Fred F. Kadlubar

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  1. Susan Kadlubar
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  2. Fred F. Kadlubar
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Correspondence to Fred F. Kadlubar .

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  1. Leslie Dan Fac. Pharmacy, University of Toronto, College Street 144, Toronto, M5S 3M2, Canada

    K. Sandy Pang

  2. Bristol-Myers Squibb Company, Princeton, 08543, U.S.A.

    A. David Rodrigues

  3. AstraZeneca UK, Alderley Park, Macclesfield, Cheshire, SK10 4TF, United Kingdom

    Raimund M. Peter

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Kadlubar, S., Kadlubar, F.F. (2010). Enzymatic Basis of Phase I and Phase II Drug Metabolism. In: Pang , K., Rodrigues, A., Peter, R. (eds) Enzyme- and Transporter-Based Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0840-7_1

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