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Enzyme- and Transporter-Based Drug-Drug Interactions

Progress and Future Challenges

  • K. Sandy  Pang
  • A. David  Rodrigues
  • Raimund M. Peter

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Determinants of Drug ADME

  3. Methods For The Study Of Drug-Drug Interactions

    1. Front Matter
      Pages 149-149
    2. Chad L. Stoner, Michael R. Wester, Benjamin J. Burke
      Pages 151-168
    3. John O. Miners, Thomas M. Polasek, Peter I. Mackenzie, Kathleen M. Knights
      Pages 217-236
    4. Kelly Bleasby, Xiaoyan Chu, Raymond Evers
      Pages 237-255
    5. Thomayant Prueksaritanont
      Pages 283-297
    6. Motohiro Kato, Yoshihisa Shitara, Masato Kitajima, Tatsuhiko Tachibana, Masaki Ishigai, Toshiharu Horie et al.
      Pages 299-315
    7. Kazuya Maeda, Yoshihisa Shitara, Toshiharu Horie, Yuichi Sugiyama
      Pages 387-412
  4. Impact Of Drug-Drug Interactions

    1. Front Matter
      Pages 413-413
    2. Catherine K. Yeung, Ping Zhao, Danny D. Shen, Kenneth E. Thummel
      Pages 415-435
    3. R. Scott Obach, Odette A. Fahmi, Robert L. Walsky
      Pages 473-495
    4. Murali Subramanian, Timothy S. Tracy
      Pages 497-515
    5. Jashvant D. Unadkat, Brian J. Kirby, Christopher J. Endres, Joseph K. Zolnerciks
      Pages 517-553
    6. Guohua An, Marilyn E. Morris
      Pages 555-584
    7. Ragini Vuppugalla, Sean Kim, Tatyana Zvyaga, Yong-hae Han, Praveen Balimane, Punit Marathe et al.
      Pages 585-624
    8. David J. Greenblatt, Lisa L. von Moltke
      Pages 625-649
    9. Rachel J. Walsh, Abhishek Srivastava, Daniel J. Antoine, Dominic P. Williams, B. Kevin Park
      Pages 651-664
  5. Regulatory Aspects And Future Developments Involving DDI

    1. Front Matter
      Pages 665-665
    2. Ping Zhao, Lei Zhang, Shiew-Mei Huang
      Pages 667-692
    3. K. Sandy Pang, Raimund M. Peter, A. David Rodrigues
      Pages 701-722
  6. Back Matter
    Pages 723-746

About this book

Introduction

This volume is authored by esteemed experts in the field, and provides state-of-the art knowledge related to enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs. It examines the types of DDIs, methodological approaches to evaluate and view DDIs mechanistically, bioinformatics, clinical and toxicological outcomes, and regulatory recommendations. As much as possible, the future challenges and opportunities that lie ahead are presented and discussed. Special emphases are placed on the quantitative assessment of the roles of different transporters, need for more specific probes and inhibitors, and recognition of extrahepatic eliminating organs. Future approaches should integrate transporters and enzymes to accelerate the development of physiological based-pharmacokinetic models (PBPK-DDI) and information related to inter-subject variability. In addition, the authors look beyond small molecules and consider DDIs involving biologic agents, such as therapeutic antibodies, that can bring about pharmacologically significant drug-cytokine or drug-endocrine interactions.

Keywords

Based Challenges Drug Enzyme Future Interactions Pang Peter Progress Rodrigues Transporter bioavailability biology cytochrome P450

Editors and affiliations

  • K. Sandy  Pang
    • 1
  • A. David  Rodrigues
    • 2
  • Raimund M. Peter
    • 3
  1. 1.Leslie Dan Fac. PharmacyUniversity of TorontoTorontoCanada
  2. 2.Bristol-Myers Squibb CompanyPrincetonU.S.A.
  3. 3.AstraZeneca UKMacclesfield, CheshireUnited Kingdom

Bibliographic information