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Reactor-Produced Medical Radionuclides

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Handbook of Nuclear Chemistry

Abstract

The therapeutic use of radionuclides in nuclear medicine, oncology, and cardiology is the most rapidly growing use of medical radionuclides. Since most therapeutic radionuclides are neutron rich and decay by β− emission, they are reactor-produced. This chapter deals mainly with production approaches with neutrons. Neutron interactions with matter, neutron transmission and activation rates, and neutron spectra of nuclear reactors are discussed in some detail. Further, a short discussion of the neutron-energy dependence of cross sections, reaction rates in thermal reactors, cross section measurements and flux monitoring, and general equations governing the reactor production of radionuclides are presented. Finally, the chapter is concluded by providing a number of examples encompassing the various possible reaction routes for the production of a number of medical radionuclides in a reactor.

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Acknowledgments

Research at ORNL was supported by the U.S. DOE under contract DE-AC05-00OR22725 with UT-Battelle, LLC. Research at BNL was supported by the U.S. DOE under Contract DE-AC02-98CH10886 with Brookhaven Science Associates.

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Authors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, TN, USA

    S. Mirzadeh & M. A. Garland

  2. Brookhaven National Laboratory, Upton, NY, USA

    L. F. Mausner

Authors
  1. S. Mirzadeh
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  2. L. F. Mausner
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  3. M. A. Garland
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Corresponding author

Correspondence to S. Mirzadeh .

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Editors and Affiliations

  1. Institute of Chemistry, Eötvös Loránd University, 32, Budapest, 1518, Hungary

    Attila Vértes (Professor Emeritus) & Sándor Nagy (Professor) (Professor Emeritus) &  (Professor)

  2. Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67, Budapest, 1025, Hungary

    Zoltán Klencsár (Dr.) (Dr.)

  3. Institute of Nuclear Research (ATOMKI), Hungarian Academy of Sciences, 51, Debrecen, 4001, Hungary

    Rezső G. Lovas (Professor) (Professor)

  4. Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany

    Frank Rösch (Professor) (Professor)

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Mirzadeh, S., Mausner, L.F., Garland, M.A. (2011). Reactor-Produced Medical Radionuclides. In: Vértes, A., Nagy, S., Klencsár, Z., Lovas, R.G., Rösch, F. (eds) Handbook of Nuclear Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0720-2_38

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