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Biomedical radioisotope generator systems

  • Medical and Industrial Applications
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Abstract

Although the99Mo→99mTc radionuclide generator system has evolved as the workhorse of nuclear medicine over the past three decades, recent developments in radionuclide generator technology have provided positron emitters for PET studies, radionuclides for therapy, and ultra short-lived radionuclides for repeated clinical applications. Attention is being paid to development ofin vivo generator systems and potential use of tandem generator systems. Separation of radionuclides in a generator system exploits differences in chemical properties of the parent-daughter pair; information is presented for these generator types based on the three chemical categories of chromatography, extraction, and volatilization and sublimation methods. This review focuses on chromatography-based systems.

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  1. Nuclear Medicine Group, Oak Ridge National Laboratory (ORNL), 37830-6229, Oaka Ridge, TN, (USA)

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Mirzadeh, S., Knapp, F.F. Biomedical radioisotope generator systems. Journal of Radioanalytical and Nuclear Chemistry, Articles 203, 471–488 (1996). https://doi.org/10.1007/BF02041524

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