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Signal Transduction Pathways Involved in Mechanotransduction in Osteoblastic and Mesenchymal Stem Cells

  • Chapter
Mechanosensitive Ion Channels

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 1))

Abstract

Bone remodeling, a process in adults that maintains bone mass through the activity of osteoblasts and osteoclasts, is regulated by mechanical forces. Mechanical loading promotes osteoblast function by increasing proliferation and differentiation of these cells. The cellular responses underlying this mechanism are termed mechanotransduction. Mechanotransduction involves various signal transduction pathways, including the activation of ion channels and other mechanoreceptors in the membrane of the bone cell, resulting in gene regulation in the nucleus. Identification and functional characterization of the mechanotransduction components may improve bone tissue engineering

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Authors
  1. Astrid Liedert
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  2. Lutz Claes
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  3. Anita Ignatius
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Editors and Affiliations

  1. Russian State Medical University, Russia and Humboldt-University, Moscow, Berlin, Germany

    Andre Kamkin  & Irina Kiseleva  & 

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Liedert, A., Claes, L., Ignatius, A. (2008). Signal Transduction Pathways Involved in Mechanotransduction in Osteoblastic and Mesenchymal Stem Cells. In: Kamkin, A., Kiseleva, I. (eds) Mechanosensitive Ion Channels. Mechanosensitivity in Cells and Tissues, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6426-5_11

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