Processing diffraction data falls naturally into three distinct steps: First, determining an initial estimate of the unit cell and orientation of the crystal; second, obtaining refined values for these parameters; and third, integrating the diffraction images. The basic principles underlying autoindexing, parameter refinement, and spot integration by summation integration and profile fitting are described.
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Leslie, A.G.W., Powell, H.R. (2007). Processing diffraction data with mosflm. In: Read, R.J., Sussman, J.L. (eds) Evolving Methods for Macromolecular Crystallography. NATO Science Series, vol 245. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6316-9_4
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