Abstract
During the last three decades many mouse lines were created or identified that are deficient in one or more peroxisomal functions. Different methodologies were applied to obtain global, hypomorph, cell type selective, inducible, and knockin mice. Whereas some models closely mimic pathologies in patients, others strongly deviate or no human counterpart has been reported. Often, mice, apparently endowed with a stronger transcriptional adaptation, have to be challenged with dietary additions or restrictions in order to trigger phenotypic changes. Depending on the inactivated peroxisomal protein, several approaches can be taken to validate the loss-of-function. Here, an overview is given of the available mouse models and their most important characteristics.
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This research was funded by grants from the KU Leuven (C14/18/088) and from the Research FoundationāFlanders (FWO G0A8619N).
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Kocherlakota, S., Swinkels, D., Van Veldhoven, P.P., Baes, M. (2023). Mouse Models to Study Peroxisomal Functions and Disorders: Overview, Caveats, and Recommendations. In: Schrader, M. (eds) Peroxisomes. Methods in Molecular Biology, vol 2643. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3048-8_34
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