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The Effects of Exercise on Lipid Biomarkers

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Physical Exercise and Natural and Synthetic Products in Health and Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2343))

Abstract

The World Health Organization has declared obesity to be a global epidemic that increases cardiovascular disease (CVD) mortality risk factors, such as hypertension, diabetes, dyslipidemia, and atherosclerosis. The increasing ratio of time spent in sedentary activities to that spent performing physically demanding tasks increases the trends to obesity and susceptibility to these risk factors. Dyslipidemia is the foundation of atherosclerotic buildup and lipoproteins serve as cofactors to the inflammatory processes that destabilize plaques. Increasing cardiorespiratory fitness and muscular strength helps attenuate concentrations of low-density lipoproteins (LDLs), such as LDL cholesterol, and increase levels of high-density lipoprotein cholesterol, as well as reduce proprotein convertase subtilisin kexin type 9 expression. Effects of physical activity on the inflammatory pathways of atherosclerosis, specifically C-reactive protein, are more closely related to reducing the levels of adiposity in tandem with increasing fitness, than with exercise training alone. The purpose of this review is to describe the physiology of dyslipidemia and relate it to CVD and exercise therapies.

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Authors and Affiliations

  1. Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines

    Michael Vaughn F. Mendoza

  2. Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA

    Sergey M. Kachur & Carl J. Lavie

  3. Department of Medicine, University of Central Florida School of Medicine, Orlando, FL, USA

    Sergey M. Kachur

Authors
  1. Michael Vaughn F. Mendoza
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  2. Sergey M. Kachur
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  3. Carl J. Lavie
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Correspondence to Carl J. Lavie .

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  1. Charlesworth House, Debden, Essex, UK

    Paul C. Guest

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Mendoza, M.V.F., Kachur, S.M., Lavie, C.J. (2022). The Effects of Exercise on Lipid Biomarkers. In: Guest, P.C. (eds) Physical Exercise and Natural and Synthetic Products in Health and Disease. Methods in Molecular Biology, vol 2343. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1558-4_6

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  • DOI: https://doi.org/10.1007/978-1-0716-1558-4_6

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