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Coronaviruses: An Updated Overview of Their Replication and Pathogenesis

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Coronaviruses

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2203))

Abstract

Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. CoVs cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs, and upper respiratory tract and kidney disease in chickens to lethal human respiratory infections. Most recently, the novel coronavirus, SARS-CoV-2, which was first identified in Wuhan, China in December 2019, is the cause of a catastrophic pandemic, COVID-19, with more than 8 million infections diagnosed worldwide by mid-June 2020. Here we provide a brief introduction to CoVs discussing their replication, pathogenicity, and current prevention and treatment strategies. We will also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), which are relevant for understanding COVID-19.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA

    Yuhang Wang, Matthew Grunewald & Stanley Perlman

Authors
  1. Yuhang Wang
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  2. Matthew Grunewald
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  3. Stanley Perlman
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Correspondence to Stanley Perlman .

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Editors and Affiliations

  1. The Pirbright Institute, Surrey, UK

    Helena J. Maier

  2. The Pirbright Institute, Surrey, UK

    Erica Bickerton

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Wang, Y., Grunewald, M., Perlman, S. (2020). Coronaviruses: An Updated Overview of Their Replication and Pathogenesis. In: Maier, H., Bickerton, E. (eds) Coronaviruses. Methods in Molecular Biology, vol 2203. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0900-2_1

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  • DOI: https://doi.org/10.1007/978-1-0716-0900-2_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0899-9

  • Online ISBN: 978-1-0716-0900-2

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