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Melanoma and Nonmelanoma Skin Cancers and the Immune System

  • Chapter
Sunlight, Vitamin D and Skin Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 624))

Abstract

A connection between tumorigenesis and the immune system has been known to exist since the late 1960s. Two pioneers in this concept were Lewis Thomas and F. Macfarlane Burnett. In 1967 Burnett introduced the concept of immunosurveillance.1 This idea is based on the concept that an intact immune system actively recognizes and rids the body of tumor cells.2,3 This concept raises several questions. If the body is indeed able to eliminate transformed cells, why do some survive, proliferate and even metastisize? Does neoplastic growth result from a breakdown on the part of the immune system or a coup on the part of the tumor cells? What circumstances lead to spontaneous regression vs. metastatic malignancy? Furthermore, if tumor cells originate from cells that were previously seen as “self” what is the significance of autoimmunity and regulation of these “surveillance” mechanisms?

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Authors and Affiliations

  1. Department of Dermatology, Case Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Ave., Lakeside 3500, Cleveland, OH, USA

    Diana Santo Domingo & Elma D. Baron

  2. Dermatology Department, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA

    Elma D. Baron

Authors
  1. Diana Santo Domingo
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  2. Elma D. Baron
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  1. Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg/Saar, Germany

    Jörg Reichrath

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Domingo, D.S., Baron, E.D. (2008). Melanoma and Nonmelanoma Skin Cancers and the Immune System. In: Reichrath, J. (eds) Sunlight, Vitamin D and Skin Cancer. Advances in Experimental Medicine and Biology, vol 624. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77574-6_15

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