Sunlight, Vitamin D and Skin Cancer

1. Front Matter

   Pages i-xxi

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2. Sunlight, UV-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need?

   • Michael F. Holick

   Pages 1-15

3. Solar Ultraviolet Irradiance and Cancer Incidence and Mortality

   • William B. Grant

   Pages 16-30

4. Vitamin D Status and Cancer Incidence and Mortality

   • Edward Giovannucci

   Pages 31-42

5. Sun Exposure and Cancer Survival in Norway: Changes in the Risk of Death with Season of Diagnosis and Latitude

   • Alina Carmen Porojnicu, Arne Dahlback, Johan Moan

   Pages 43-54

6. Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes

   • Heike A. Bischoff-Ferrari

   Pages 55-71

7. Ultraviolet Exposure Scenarios: Risks of Erythema from Recommendations on Cutaneous Vitamin D Synthesis

   • Ann R. Webb, Ola Engelsen

   Pages 72-85

8. At What Time Should One Go Out in the Sun?

   • Johan Moan, Arne Dahlback, Alina Carmen Porojnicu

   Pages 86-88

9. Epidemiology of Melanoma and Nonmelanoma Skin Cancer—The Role of Sunlight

   • Ulrike Leiter, Claus Garbe

   Pages 89-103

10. Ultraviolet Radiation and Malignant Melanoma

    • Johan Moan, Alina Carmen Porojnicu, Arne Dahlback

    Pages 104-116

11. Solar UV Exposure and Mortality from Skin Tumors

    • Marianne Berwick, Anne Lachiewicz, Claire Pestak, Nancy Thomas

    Pages 117-124

12. Health Initiatives for the Prevention of Skin Cancer

    • Rüdiger Greinert, Eckhard W. Breitbart, Peter Mohr, Beate Volkmer

    Pages 125-136

13. Sunscreens

    • Guido Bens

    Pages 137-161

14. UV Damage and DNA Repair in Malignant Melanoma and Nonmelanoma Skin Cancer

    • Knuth Rass, Jörg Reichrath

    Pages 162-178

15. Role of Viruses in the Development of Squamous Cell Cancer and Melanoma

    • Ulrich R. Hengge

    Pages 179-186

16. Melanoma and Nonmelanoma Skin Cancers and the Immune System

    • Diana Santo Domingo, Elma D. Baron

    Pages 187-202

17. Solar UV-Radiation, Vitamin D and Skin Cancer Surveillance in Organ Transplant Recipients (OTRs)

    • Jörg Reichrath, Bernd Nürnberg

    Pages 203-214

18. Histology of Melanoma and Nonmelanoma Skin Cancer

    • Cornelia S. L. Mueller, Jörg Reichrath

    Pages 215-226

19. Cytogenetics of Melanoma and Nonmelanoma Skin Cancer

    • Melanie A. Carless, Lyn R. Griffiths

    Pages 227-240

20. Molecular Biology of Basal and Squamous Cell Carcinomas

    • Jingwu Xie

    Pages 241-251

UV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun—a serious problem—for a connection between vitamin D deficiency and various types of cancer (e. g. , colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer.

• apoptosis
• cancer
• carcinoma
• cell
• cytogenetics
• endocrinology
• epidemiology
• genetics
• histology
• melanoma
• molecular biology
• mortality
• pathology
• prevention
• skin cancer

From the reviews:

"Small print, information dense and richly referenced volume … of the current knowledge on this controversial topic. The text covers history, epidemiology, biochemistry, histology, immunology, and molecular biology. … Lactation consultants depend on advice from public health officials to counsel their clients as well as to care for their own families. They can confidently use the content of this book to pressure officials to formulate recommendations that are more in line with the needs of the general population, including breastfeeding babies." (Nicole J Bernshaw, International Lactation Consultant Association Print and Multimedia Reviews, August, 2008)

• Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg/Saar, Germany

  Jörg Reichrath

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