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Patterns of Metastasis in Human Solid Cancers

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Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 135))

To date, lymph node status is the most important predictor for clinical outcome. Clinical models of cancer metastasis have evolved from Halsted’s lymphatic dominant model in which the regional lymph nodes served as filters for cancer cells. When the filter was filled, the cancer cells would move to the other lymph nodes and distant sites. The Halsted’s model (1) was then replaced by Fisher’s model in which all breast cancers were considered to be systemic from their onset (2).

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Authors and Affiliations

  1. Department of Surgery, University of California San Francisco, 1600 Divisadero Street, 94143, San Francisco, CA, USA

    Director Stanley P. L. Leong MD, FACS, David M. Jablons MD & Julio Garcia-Aguilar MD

  2. Department of Surgery, Brown Medical School, Rhode Island Hospital, Providence, RI, USA

    Blake Cady MD

  3. Lakeland Regional Cancer Center, Lakeland, FL, USA

    Douglas Reintgen MD

  4. Department of Otolaryngology, Head and Neck Surgery, Philipps-University Marburg, Marbug, Germany

    Jochen A. Werner MD, PhD

  5. Department of Surgery, Keio University School of Medicine, Tokyo, Japan

    Yuko Kitagawa MD, PhD

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  1. University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, 94143, San Francisco, CA, USA

    Stanley P. L. Leong MD, FACS

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Leong, S.P.L. et al. (2007). Patterns of Metastasis in Human Solid Cancers. In: Leong, S.P.L. (eds) Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy. Cancer Treatment and Research, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69219-7_16

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