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Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways

  • Chapter
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 594))

Abstract

The transition from normal growth conditions to stressful conditions is accompanied by a robust upregulation of heat shock proteins, which dampen the cytotoxicity caused by misfolded and denatured proteins. The most prominent part of this transition occurs on the transcriptional level. In mammals, protein-damaging stress leads to the activation of heat shock factor 1 (HSF1), which binds to upstream regulatory sequences in the promoters of heat shock genes. The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. In addition to its established role as the main regulator of heat shock genes, new data link HSF1 to developmental pathways. In this chapter, we examine the established stress-related functions and prospect the intriguing role of HSF1 as a developmental coordinator.

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Authors and Affiliations

  1. Department of Biology, Åbo Akademi University and Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, P.O. Box 123, FI-20521, Turku, Finland

    Julius Anckar & Lea Sistonen

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  1. Julius Anckar
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  2. Lea Sistonen
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Correspondence to Lea Sistonen .

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Editors and Affiliations

  1. Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

    Peter Csermely

  2. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

    László Vígh

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Anckar, J., Sistonen, L. (2007). Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways. In: Csermely, P., Vígh, L. (eds) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks. Advances in Experimental Medicine and Biology, vol 594. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39975-1_8

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