Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

1. Front Matter

   Pages i-xviii

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2. Protein Misassembly

   • R. John Ellis

   Pages 1-13

3. The Cellular “Networking” of Mammalian Hsp27 and Its Functions in the Control of Protein Folding, Redox State and Apoptosis

   • André-Patrick Arrigo

   Pages 14-26

4. Molecular Interaction Network of the Hsp90 Chaperone System

   • Rongmin Zhao, Walid A. Houry

   Pages 27-36

5. Organization of the Functions and Components of the Endoplasmic Reticulum

   • Yuichiro Shimizu, Linda M. Hendershot

   Pages 37-46

6. Molecular Crime and Cellular Punishment

   • Marie-Pierre Hinault, Pierre Goloubinoff

   Pages 47-54

7. Chaperones as Parts of Cellular Networks

   • Peter Csermely, Csaba Söti, Gregory L. Blatch

   Pages 55-63

8. Chaperones as Parts of Organelle Networks

   • György Szabadkai, Rosario Rizzuto

   Pages 64-77

9. Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways

   • Julius Anckar, Lea Sistonen

   Pages 78-88

10. Chaperone Regulation of the Heat Shock Protein Response

    • Richard Voellmy, Frank Boellmann

    Pages 89-99

11. Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways

    • Sébastien Ian Nadeau, Jacques Landry

    Pages 100-113

12. Membrane-Regulated Stress Response

    • László Vígh, Zsolt Török, Gábor Balogh, Attila Glatz, Stefano Piotto, Ibolya Horváth

    Pages 114-131

13. Beyond the Lipid Hypothesis

    • Scott A. L. Hayward, Patricia A. Murray, Andrew Y. Gracey, Andrew R. Cossins

    Pages 132-142

14. Trehalose As a “Chemical Chaperone”

    • John H. Crowe

    Pages 143-158

15. Chaperones As Part of Immune Networks

    • Zoltán Prohászka

    Pages 159-166

16. The Stress of Misfolded Proteins

    • Heather R. Brignull, James F. Morley, Richard I. Morimoto

    Pages 167-189

17. Hsp90 and Developmental Networks

    • Suzannah Rutherford, Jennifer R. Knapp, Peter Csermely

    Pages 190-197

18. Back Matter

    Pages 199-201

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We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes. The volume starts with an introduction to the concept of molecular chaperones in their original sense: R. John Ellis, the founder of the chaperone concept describes chaperones as mediators of correct assembly and/or misassembly of other macromolecular complexes. This sets the tone of the book, where later chapters give detailed examples of the richness of chaperone ac­ tion by hundreds of other proteins and membrane structures. The reader will learn the role of chaperone classes such as Hsp27 or Hsp90, the action of highly organized chaperone networks in various cellular compartments such as the ER or mitochondrial/ER networks as well as the molecular details of the signaling mechanisms leading to chaperone induction during stress. Various special stress defense mechanisms against oxidative stress or dryness will also be covered. Membranes comprise a surprising mixture of stability and dynamics in the cell. Their role in the regulation of the stress response has been accepted only slowly in the field. Two chapters summarize this important aspect of the stress response showing the importance of membrane hyperstructures, lipid species composition, protein/ membrane interactions and cold adaptation.

• Activation
• Chaperone
• Chaperones
• Csermely
• Lipid
• Organelle
• Response
• Stress
• regulation

• Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

  Peter Csermely

• Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

  László Vígh

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