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Unfolded Protein Response: Contributions to Development and Disease

  • Chapter
Cell Stress Proteins

Part of the book series: Protein Reviews ((PRON,volume 7))

Abstract

The unfolded protein response (UPR) is a multifaceted signal transduction pathway that is activated in all eukaryotic organisms in response to changes in the environment of the endoplasmic reticulum (ER) that adversely affect protein folding and assembly in the secretory pathway. The response is generally thought to protect cells from the transient alterations that can occur in the ER environment and serves to restore homeostatis in this organelle. Under extreme or prolonged stress, apoptotic pathways can be activated to destroy the cell. Recent studies reveal that in addition to protecting cells from adverse physiological conditions, the UPR plays an essential role in the normal development and functioning of some tissues and can be a major contributor to the pathology of some diseases.

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Author information

Authors and Affiliations

  1. Department of Molecular Sciences, University of Tennessee, Health Science Center, Memphis, TN, 38163

    Nan Liao & Linda M. Hendershot

  2. Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, TN, 38105

    Linda M. Hendershot

Authors
  1. Nan Liao
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  2. Linda M. Hendershot
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Harbard Medical School, Beth, Israel

    Stuart K. Calderwood

  2. Deaconess Medical Center, Boston, Massachusetts

    Stuart K. Calderwood

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Liao, N., Hendershot, L.M. (2007). Unfolded Protein Response: Contributions to Development and Disease. In: Calderwood, S.K. (eds) Cell Stress Proteins. Protein Reviews, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39717-7_4

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