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Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects

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Cell Biology and Translational Medicine, Volume 18

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1409))

Abstract

A spinal cord injury (SCI) is a very debilitating condition causing loss of sensory and motor function as well as multiple organ failures. Current therapeutic options like surgery and pharmacotherapy show positive results but are incapable of providing a complete cure for chronic SCI symptoms. Tissue engineering, including neuroprotective or growth factors, stem cells, and biomaterial scaffolds, grabs attention because of their potential for regeneration and ability to bridge the gap in the injured spinal cord (SC). Preclinical studies with tissue engineering showed functional recovery and neurorestorative effects. Few clinical trials show the safety and efficacy of the tissue engineering approach. However, more studies should be carried out for potential treatment modalities. In this review, we summarize the pathophysiology of SCI and its current treatment modalities, including surgical, pharmacological, and tissue engineering approaches following SCI in preclinical and clinical phases.

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Authors and Affiliations

  1. Department of Stem Cells and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, India

    Leena R. Chaudhari, Akshay A. Kawale, Shivaji B. Kashte & Meghnad G. Joshi

  2. Department of Obstetrics and Gynecology, Dr. D Y Patil Medical College, Hospital and Research Institute, Kolhapur, Maharashtra, India

    Sangeeta S. Desai

  3. Stem Plus Biotech, SMK Commercial Complex, Sangli, Maharashtra, India

    Meghnad G. Joshi

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  1. Leena R. Chaudhari
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  2. Akshay A. Kawale
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  3. Sangeeta S. Desai
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  4. Shivaji B. Kashte
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  5. Meghnad G. Joshi
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Correspondence to Meghnad G. Joshi .

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  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Chaudhari, L.R., Kawale, A.A., Desai, S.S., Kashte, S.B., Joshi, M.G. (2022). Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 18. Advances in Experimental Medicine and Biology(), vol 1409. Springer, Cham. https://doi.org/10.1007/5584_2022_731

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