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Control of mRNA Stability by SAPKs

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Stress-Activated Protein Kinases

Part of the book series: Topics in Current Genetics ((TCG,volume 20))

Abstract

Control of mRNA turnover is an essential step in the regulation of gene expression in eukaryotes. The concerted action of many enzymes regulates the way each mRNA is degraded. Moreover, the degradation of each mRNA is influenced by the environment surrounding the cell. The connection between the environment and changes in the half-lives of mRNAs is regulated by the activity of stress activated MAP kinases (SAPKs) and their substrates. Here, we will describe some of those mechanisms, and how SAPKs regulate mRNA stability in eukaryotic cells.

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Authors and Affiliations

  1. Depto. Microbiologia II. Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain

    Miguel A. Rodríguez-Gabriel

  2. Dept. Molecular Biology, The Scripps Research Institute, 92037, La Jolla, CA, USA

    Paul Russell

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  1. Miguel A. Rodríguez-Gabriel
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Correspondence to Paul Russell .

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Francesc Posas Angel R. Nebreda

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Rodríguez-Gabriel, M.A., Russell, P. (2007). Control of mRNA Stability by SAPKs. In: Posas, F., Nebreda, A.R. (eds) Stress-Activated Protein Kinases. Topics in Current Genetics, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2007_0248

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