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Amino Acid Production Processes

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Microbial Production of l-Amino Acids

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 79))

Abstract

With the exploitation of new uses and the growing markets of amino acids, amino acid production technology has made large progress during the latter half of the 20th century. Fermentation technology has played crucial roles in this progress, and currently the fermented amino acids represent chief products of biotechnology in both volume and value. This area is highly competitive in the world market and process economics are of primary importance. For cost-effective production, many technologies have been developed to establish high-productive fermentation and recovery processes. The producer organisms used in large-scale, well-established processes have been developed to a high level of production efficiency. The tools of genetic engineering of amino acid-producing organisms have been well developed and are now being applied for enlargement of biosynthetic and transport capacity, which is beginning to have a great impact on the amino acid industry. Furthermore, the rapid strides in genome analysis are bound to revolutionize the strain improvement methodology.

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References

  1. Ikeda K (1908) J Tokyo Chem Soc 30:820

    Google Scholar 

  2. Kinoshita S, Udaka S, Shimono M (1957) J Gen Appl Microbiol 3:193

    Article  CAS  Google Scholar 

  3. Nakayama K, Kitada S, Kinoshita S (1961) J Gen Appl Microbiol 7:145

    Article  CAS  Google Scholar 

  4. The Japan Essential Amino Acids Association, Inc (1996)

    Google Scholar 

  5. Sano K, Yokozeki K, Tamura F, Yasuda N, Noda I, Mitsugi K (1977) Appl Environ Microbiol 34:806

    CAS  Google Scholar 

  6. Calmes M, Daunis J (1999) Amino Acids 16:215

    Article  CAS  Google Scholar 

  7. Esaki N, Nakamori S, Kurihara T, Furuyoshi S, Soda K (1996) Enzymology of amino acid production. In: Roehr M (ed) Biotechnology, 2nd edn, vol. 6: Products of primary metabolism. VCH Verlagsgesellschaft mbH, Weinheim, p 503

    Google Scholar 

  8. Chibata I, Tosa T, Sato T (1986) Aspartic acid. In: Aida K, Chibata I, Nakayama K, Takinami K, Yamada H (eds) Biotechnology of amino acid production. Elsevier, Amsterdam Oxford New York Tokyo, p 144

    Google Scholar 

  9. Chibata I, Tosa T, Kakimoto T (1986) Alanine. In: Aida K, Chibata I, Nakayama K, Takinami K, Yamada H (eds) Biotechnology of amino acid production. Elsevier, Amsterdam Oxford New York Tokyo, p 224

    Google Scholar 

  10. Sato T, Takamatsu S, Yamamoto K, Umemura I, Tosa T, Chibata I (1982) Enzyme Eng 6:271

    Google Scholar 

  11. Hodgson J (1994) Bio/Technology 12:152

    Article  CAS  Google Scholar 

  12. Sikyta B (1983) Methods in industrial microbiology. Ellis Horwood, Chichester

    Google Scholar 

  13. Buckland BC, Lilly MD (1993) Fermentation: an overview. In: Stephanopoulos G (ed) Biotechnology, 2nd edition, vol. 3: Bioprocessing. VCH Verlagsgesellschaft mbH, Weinheim, p 7

    Google Scholar 

  14. Einsele A (1978) Proc Biochem 7:1

    Google Scholar 

  15. Enfors SO, Jahic M, Rozkov A, Xu B, Hecker M, Jürgen B, Krüger E, Schwedwe T, Hamer G, O’Beirne D, Noisommit-Rizzi N, Reuss M, Boone L, Hewitt C, MacFarlane C, Nienow A, Fuchs L, Kovacs T, Revstedt J, Trägårdh C, Friberg PC, Hjertager B, Blomsten G, Skogman H, Hjort S, Hoeks F, Struder F, Lin HY, Neubauer P, Riemschneider S, van der Lans R, Luyben K, van der Schot F, Vrabel P, Manelius Å (1998) In: Azevedo SF, Ferreira EC, Luyben KCAM, Osseweijer P (eds) 2nd European Symposium on Biochemical Engineering Science, Portugal, p 7

    Google Scholar 

  16. Schilling BM, Pfeffele W, Backmann B, Leuchtenberger W, Deckwer W-D (1999) Biotechnol Bioeng 64:599

    Article  CAS  Google Scholar 

  17. Yamane T, Shimizu S (1984) Fed-batch techniques in microbial processes. In: Fiechter A (ed) Advances in biochemical engineering/biotechnology. Springer, Berlin Heidelberg New York, p 147

    Google Scholar 

  18. Konstantinov KB, Nishio N, Yoshida T (1990) J Ferment Bioeng 70:253

    Article  CAS  Google Scholar 

  19. Konstantinov KB, Nishio N, Seki T, Yoshida T (1991) J Ferment Bioeng 71:350

    Article  CAS  Google Scholar 

  20. Ikeda M, Katsumata R (1999) Appl Environ Microbiol 65:2497

    CAS  Google Scholar 

  21. Srinivasan VR, Summers RJ (1981) Continuous culture in the fermentation industry. In: Calcott PH (ed) Continuous cultures of cells. CRC Press, Florida, p 97

    Google Scholar 

  22. Aeschlimann A, Di Stasi L, von Stockar U (1990) Enzyme Microbiol Technol 12:926

    Article  CAS  Google Scholar 

  23. Miura A, Yoshida T, Matsuno T, Hashida W, Taguchi H, Otake T, Teramoto S (1963) J Ferment Technol 41:275

    Google Scholar 

  24. Choi YJ, Tribe DE (1982) Biotechnol Lett 4:223

    Article  CAS  Google Scholar 

  25. Park NH, Rogers PL (1986) Chem Eng Commun 45:185

    Article  CAS  Google Scholar 

  26. Toma M, Svinka J, Ruklisa MP, Sakse A, Baburin LA (1984) Prikl Biokhim Mikrobiol 20:95

    CAS  Google Scholar 

  27. Fujimura M, Kato J, Tosa T, Chibata I (1984) Appl Microbiol Biotechnol 19:79

    Article  CAS  Google Scholar 

  28. Azuma T, Nakanishi T, Sugimoto M (1988) J Ferment Technol 3:279

    Article  Google Scholar 

  29. Azuma T, Nakanishi T (1988) J Ferment Technol 3:285

    Article  Google Scholar 

  30. Hirao T, Nakano T, Azuma T, Sugimoto M, Nakanishi T (1989) Appl Microbiol Biotechnol 32:269

    Article  CAS  Google Scholar 

  31. Okamoto K, Kino K, Ikeda M (1997) Biosci Biotechnol Biochem 61:1877

    CAS  Google Scholar 

  32. Hashimoto S, Katsumata R (1999) Appl Environ Microbiol 65:2781

    CAS  Google Scholar 

  33. Ishizaki A, Takasaki S, Furuta Y (1993) J Ferment Bioeng 76:316

    Article  CAS  Google Scholar 

  34. Hirose T, Tsuruta M, Tamura K, Uehara Y, Miwa H (1994) US Patent 5 362 635

    Google Scholar 

  35. Coello N, Pan JG, Lebeault JM (1992) Appl Microbiol Biotechnol 38:34

    CAS  Google Scholar 

  36. Coello N, Pan JG, Lebeault JM (1992) Appl Microbiol Biotechnol 38:259

    CAS  Google Scholar 

  37. Oh N-S. Sernetz M (1993) Appl Microbiol Biotechnol 39:691

    Article  CAS  Google Scholar 

  38. Lee H-W, Pan J-G, Lebefault J-M (1995) Appl Microbiol Biotechnol 43:1019

    Article  CAS  Google Scholar 

  39. Oki T, Kitai A, Kouno K, Ozaki A (1973) J Gen Appl Microbiol 19:79

    Article  CAS  Google Scholar 

  40. Motoyama H, Anazawa H, Katsumata R, Araki K, Teshiba S (1993) Biosci Biotechnol Biochem 57:82

    CAS  Google Scholar 

  41. Schendel FJ, Bremmon CE, Flickinger MC, Guettler M, Hanson RS (1990) Appl Environ Microbiol 56:963

    CAS  Google Scholar 

  42. Suzuki M, Berglund A, Unden A, Heden CG (1977) J Ferment Technol 55:466

    CAS  Google Scholar 

  43. Yamada H, Morinaga Y, Tani Y (1982) Agric Biol Chem 46:47

    CAS  Google Scholar 

  44. Izumi Y, Yoshida T, Miyazaki SS, Mitsunaga T, Ohshiro T, Shimao M, Miyata A, Tanabe T (1993) Appl Microbiol Biotechnol 39:427

    Article  CAS  Google Scholar 

  45. Okamoto K, Ikeda M (2000) J Biosci Bioeng 89:87

    Article  CAS  Google Scholar 

  46. Jain D, Buckland BC (1988) Bioprocess Eng 3:31

    Article  CAS  Google Scholar 

  47. Liebl W, Ehrmann M, Ludwig W, Schleifer KH (1991) Int J Syst Bacterio l41:225

    Google Scholar 

  48. Kinoshita S (1999) Taxonomic position of glutamic acid producing bacteria. In: Flickinger MC, Drew SW (eds) Encyclopedia of bioprocess technology: fermentation, biocatalysis, and bioseparation. Wiley, p 1330

    Google Scholar 

  49. Yamada K, Seto A (1988) Japan Patent 63 240 779 A

    Google Scholar 

  50. Murakami Y, Miwa H, Nakamori S (1992) Japan Patent 4 004 887 A

    Google Scholar 

  51. Kelle R, Hermann T, Weuster-Botz D, Eggeling L, Krämer R, Wandrey C (1996) J Biotechnol 50:123

    Article  CAS  Google Scholar 

  52. Ono Y, Sato K (1996) Japan Patent 8 266 295 A

    Google Scholar 

  53. Nakano T, Azuma T, Kuratsu Y (1993) Japan Patent 5 111 386A

    Google Scholar 

  54. Sassi AH, Deschamps AM, Lebeault JM (1996) Process Biochem 31:493

    Article  CAS  Google Scholar 

  55. Eggeling L, Oberle S, Sahm H (1998) Appl Microbiol Biotechnol 49:24

    Article  CAS  Google Scholar 

  56. Yokomori M, Totsuka K, Kawahara Y, Miwa H, Ohsumi T (1994) Japan Patent 6 007 182 A

    Google Scholar 

  57. Shiratsuchi M, Kuronuma H, Kawahara Y, Yoshihara Y, Miwa H, Nakamori S (1995) Biosci Biotechnol Biochem 59:83

    CAS  Google Scholar 

  58. Sugimoto M, Otsuna S, Nagase K, Tsuchiya M, Matsui H, Yoshihara Y, Nakamatsu T (1996) Japan Patent 8 196 280 A

    Google Scholar 

  59. Hayakawa A, Sugimoto M, Yoshihara Y, Nakamatsu T (1998) Japan Patent 10 165 180 A

    Google Scholar 

  60. Araki M, Sugimoto M, Yoshihara Y, Nakamatsu T (1998) Japan Patent 10 215 883 A

    Google Scholar 

  61. Kojima H, Totsuka K (1995) WO9 511 985

    Google Scholar 

  62. Kojima H, Ogawa Y, Kawamura K, Sano K (1999) Japan Patent 11 285 381 A

    Google Scholar 

  63. Lee GH, Hur W, Bremmon CE, Flickinger MC (1996) Biotechnol Bioeng 49:639

    Article  CAS  Google Scholar 

  64. Kimura E, Abe C, Kawahara Y, Yoshihara Y, Nakamatsu T (1995) WO9 523 224

    Google Scholar 

  65. Asakura Y, Kimura E, Abe C, Kawahara Y, Nakamatsu T, Usuda Y, Tsujimoto N, Kurahashi O (1995) WO9 534 672

    Google Scholar 

  66. Matsui K, Izui H (1997) Japan Patent 9 285 293 A

    Google Scholar 

  67. Ogawa T, Hirao N, Furukawa S, Azuma T, Kuratsu Y (1994) Japan Patent 6 000 092 A

    Google Scholar 

  68. Tsuchida T, Ohtsuka N, Takeuchi H, Uctihori H (1990) Japan Patent 2 186 995 A

    Google Scholar 

  69. Chibata I, Kisumi M, Takagi T (1983) Japan Patent 58 009 692 A

    Google Scholar 

  70. Shimizu E, Ohsumi T, Heima H, Tanaka T, Kurashige J, Enei H, Miwa K, Nakamori S (1995) Biosci Biotechnol Biochem 59:1095

    CAS  Google Scholar 

  71. Kurahashi O, Beyou A, Takinami K, Jarry B, Richaud F (1992) Asia-pacific biochemical engineering conference, Japan, p 129

    Google Scholar 

  72. Debabov VG, Kozlov JI, Khurges EM, Livshits VA, Zhdanova NI, Gusyatiner MM, Sokolov AK, Bachina TA, Chistoserdov AJ, Tsigankov JD, Yankovsky NK, Mashko SV, Lapidus AL, Gavrilova OF, Rodionov OA (1994) Eur Patent 593 792

    Google Scholar 

  73. Masuda M, Takamatsu S, Nishimura N, Komatsubara S, Tosa T (1992) Appl Biochem Biotech 37:255

    Article  CAS  Google Scholar 

  74. Katsumata R, Mizukami T, Kikuchi Y, Kino K (1986) Threonine production by the lysine producing strain of Corynebacterium glutamicum with amplified threonine biosynthetic operon. In: Alacevic M, Hranueli D, Toman Z (eds) Genetics of industrial microorganisms. Yugoslavia, p 217

    Google Scholar 

  75. Ishida M, Kawashima H, Sato K, Hashiguchi K, Ito H, Enei H, Nakamori S (1994) Biosci Biotechnol Biochem 58:768

    CAS  Google Scholar 

  76. Kino K, Okamoto K, Takeda Y, Kuratsu Y (1993) Japan Patent 5 304 969 A

    Google Scholar 

  77. Nakano T, Nakayama M, Shitashige M, Ikeda M, Furukawa S (1996) Japan Patent 8 009 982 A

    Google Scholar 

  78. Hashiguchi K, Takesada H, Suzuki E, Matsui H (1999) Biosci Biotechnol Biochem 63:672

    Article  CAS  Google Scholar 

  79. Colón GE, Nguyen TT, Jetten MSM, Sinskey AJ, Stephanopoulos G (1995) Appl Microbiol Biotechnol 43:482

    Article  Google Scholar 

  80. Hashimoto S, Katsumata R (1996) In: Proc Ann Meet Agric Chem Soc Japan, p 279

    Google Scholar 

  81. Ajijian AG, Abeteisowa GE, Arushanian AU, Kocharian SM (1992) Japan Patent 4 045 160B4

    Google Scholar 

  82. Tomita F, Yokota A, Hashiguchi K, Ishigooka M, Kurahashi O (1996) WO9 606 926

    Google Scholar 

  83. Hashimoto S, Katsumata R (1998) J Ferment Bioeng 86:385

    Article  CAS  Google Scholar 

  84. Uhlenbusch I, Sahm H, Sprenger GA (1991) Appl Environ Microbiol 57:1360

    CAS  Google Scholar 

  85. Hols P, Kleerebezem M, Schanck AN, Ferain T, Hugenholtz J, Delcour J, de Vos WM (1999) Nature Biotechnol 17:588

    Article  CAS  Google Scholar 

  86. Hagishita T, Yoshida T, Izumi Y, Mitsunaga T (1996) Biosci Biotechnol Biochem 60:1604

    CAS  Google Scholar 

  87. Suga M, Sugimoto M, Osumi T, Nakamatsu T, Hibino W, Ito M (1999) Japan Patent 11 253 187 A

    Google Scholar 

  88. Ikeda M, Katsumata R (1995) Biosci Biotechnol Biochem 59:1600

    CAS  Google Scholar 

  89. Camakaris H, Cowan P, James P (1997) Eur Patent 789 073 A2

    Google Scholar 

  90. Azuma S, Tsunekawa H, Okabe M, Okamoto R, Aiba S (1993) Appl Microbiol Biotechnol 39:471

    Article  CAS  Google Scholar 

  91. Chan E-C, Tsai H-L, Chen S-L, Mou D-G (1993) Appl Microbiol Biotechnol 40:301

    Article  CAS  Google Scholar 

  92. BerryA (1996) Tibtech 14:250

    Google Scholar 

  93. Kurahashi O, Noda-Watanabe M, Toride Y, Takenouchi T, Akashi K, Morinaga Y, Enei H (1987) Agric Biol Chem 51:1791

    CAS  Google Scholar 

  94. Yajima Y, Sakimoto K, Takahashi K (1990) Japan Patent 2 190 182 A

    Google Scholar 

  95. Ikeda M, Katsumata R (1992) Appl Environ Microbiol 58:781

    CAS  Google Scholar 

  96. Ito H, Sato K, Matsui K (1990) Appl Microbiol Biotechnol 33:190

    Article  CAS  Google Scholar 

  97. Igarashi K, Kishino M, Seki M, Takenouchi T, Kureyama M (1993) Japan Patent 5 304 971 A

    Google Scholar 

  98. Konstantinov BK, Nishio N, Yoshida T (1990) J Ferment Technol 70:253

    CAS  Google Scholar 

  99. Choi HK, Kim HY, Lee DJ, Lim BL, Rhym H, Won CH, Choi HG (1992) US Patent 5 304 475

    Google Scholar 

  100. Backman K, O’Connor MJ, Maruya A, Rudd E, McKay D, Balakrishnan R, Radjai M, Di-Pasquantonio V, Shoda D, Hatch R, Venkatasubramanian K (1990) Ann NY Acad Sci 589:16

    Article  CAS  Google Scholar 

  101. Mizukami T, Hamu A, Ikeda M, Oka T, Katsumata R (1994) Biosci Biotechnol Biochem 58:635

    CAS  Google Scholar 

  102. Sugiura M, Suzuki S, Kisumi M (1987) Agric Biol Chem 51:371

    CAS  Google Scholar 

  103. Oka T (1999) Amino acids, production processes. In: Flickinger MC, Drew SW (eds) Encyclopedia of bioprocess technology: fermentation, biocatalysis, and bioseparation. Wiley, p 89

    Google Scholar 

  104. Ohtani M, Kitahara T, Akashi K (1987) French Patent 2 588 016

    Google Scholar 

  105. Katsumata R, Ozaki A, Oka T, Furuya A (1984) J Bacteriol 159:306

    CAS  Google Scholar 

  106. Ozaki A, Katsumata R, Oka T, Furuya A (1984) Mol Gen Genet 196:175

    Article  CAS  Google Scholar 

  107. Santamaria R, Gil JA, Mesas JM, Martin JF (1984) J Gen Microbiol 130:2237

    CAS  Google Scholar 

  108. Yoshihama M, Higashiro K, Rao EA, Akedo M, Shanabruch WG, Folletie MT, Walker GC, Sinskey AJ (1985) J Bacteriol 162:591

    CAS  Google Scholar 

  109. Schwarzer A, Pühler A (1991) Bio/Technology 9:84

    Article  CAS  Google Scholar 

  110. Reyes O, Guyonvarch A, Bonamy C, Salti V, David F, Leblon G (1991) Gene 107:61

    Article  CAS  Google Scholar 

  111. Vertés AA, Hatakeyama K, Inui M, Kobayashi M, Kurusu Y, Yukawa H (1993) Biosci Biotechnol Biochem 57:2036

    Google Scholar 

  112. Sugimoto M, Kojima H, Tanaka A, Matsui H, Sato K, Nakamatsu T (1993) Japan Patent 5 007 491 A

    Google Scholar 

  113. Ikeda M, Katsumata R (1998) Microbiology 144:1863

    CAS  Google Scholar 

  114. Ozaki A, Katsumata R, Oka T, Furuya A (1985) Agric Biol Chem 49:2925

    CAS  Google Scholar 

  115. Ikeda M, Ozaki A, Katsumata R (1993) Appl Microbiol Biotechnol 39:318

    Article  CAS  Google Scholar 

  116. Guillouet S, Rodal AA, An G, Lessard PA, Sinskey AJ (1999) Appl Environ Microbiol 65:3100

    CAS  Google Scholar 

  117. Hashimoto S, Katsumata R (1995) In: Proc Ann Meet Agric Chem Soc Japan, p 440

    Google Scholar 

  118. Katsumata R, Ikeda M (1993) Bio/Technology 11:921

    Article  CAS  Google Scholar 

  119. Ikeda M, Nakanishi K, Kino K, Katsumata R (1994) Biosci Biotechnol Biochem 58:674

    CAS  Google Scholar 

  120. Kinoshita S, Tanaka K (1972) Glutamic acid. In: Yamada K (ed) The microbial production of amino acids. Wiley, p 263

    Google Scholar 

  121. Vallino JJ, Stephanopoulos G (1993) Biotechnol Bioeng 41:633

    Article  CAS  Google Scholar 

  122. Yamaguchi K, Ishino S, Araki K, Shirahata K (1986) Agric Biol Chem 50:2453

    CAS  Google Scholar 

  123. Ishino S, Shimomura-Nishimuta J, Yamaguchi K, Shirahata K, Araki K (1991) J Gen Appl Microbiol 37:157

    Article  CAS  Google Scholar 

  124. Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H (1996) Biotechnol Bioeng 49:111

    Article  CAS  Google Scholar 

  125. Gubler M, Jetten G, Lee S, Sinskey AJ (1994) Appl Environ Microbiol 60:2494

    CAS  Google Scholar 

  126. Peters-Wendisch PG, Eikmanns BJ, Thierbach G, Backmann B, Sahm H (1993) FEMS Microbiol Lett 112:269

    Article  CAS  Google Scholar 

  127. Gubler M, Park SM, Jetten M, Stephanopoulos G, Sinskey AJ (1994) Appl Microbiol Biotechnol 40:857

    Article  CAS  Google Scholar 

  128. Jetten MSM, Pitoc GA, Follettie MT, Sinskey AJ (1994) Appl Microbiol Biotechnol 41:47

    CAS  Google Scholar 

  129. Park SM, Shaw-Reid C, Sinskey AJ, Stephanopoulos G (1997) Appl Microbiol Biotechnol 47:430

    Article  CAS  Google Scholar 

  130. Peters-Wendisch PG, Wendisch VF, Paul S, Eikmanns BJ, Sahm H (1997) Microbiology 143:1095

    CAS  Google Scholar 

  131. Cocaign-Bousquet M, Guyonvarch A, Lindley ND (1996) Appl Environ Microbiol 62:429

    CAS  Google Scholar 

  132. Ihnen ED, Demain AL (1969) J Bacteriol 98:1151

    CAS  Google Scholar 

  133. Ikeda M, Okamoto K, Katsumata R (1998) Appl Microbiol Biotechnol 50:375

    Article  CAS  Google Scholar 

  134. Fraenkel DG, Vinopal RT (1973) Annu Rev Microbiol 27:69

    Article  CAS  Google Scholar 

  135. Ikeda M, Okamoto K, Katsumata R (1999) Appl Microbiol Biotechnol 51:201

    Article  CAS  Google Scholar 

  136. Ikeda M, Okamoto K, Nakano T, Kamada N (2000) Japan Patent 12 014 396 A

    Google Scholar 

  137. Kimura E, Abe C, Kawahara Y, Nakamatsu T (1996) Biosci Biotechnol Biochem 60:1565

    CAS  Google Scholar 

  138. Kawahara Y, Takahashi-Fuke K, Shimizu E, Nakamatsu T, Nakamori S (1997) Biosci Biotechnol Biochem 61:1109

    CAS  Google Scholar 

  139. Kimura E, Abe C, Kawahara Y, Nakamatsu T, Tokuda H (1997) Biochem Biophys Res Commun 234:157

    Article  CAS  Google Scholar 

  140. Kimura E, Yagoshi C, Kawahara Y, Ohsumi T, Nakamatsu T, Tokuda H (1999) Biosci Biotechnol Biochem 63:1274

    Article  CAS  Google Scholar 

  141. NCBI sequence database, GenBank, http://www.ncbi.nlm.nih.gov

  142. O’Regan M, Thierbach G, Bachmann B, Villeval D, Lepage P, Viret JF, Lemoine Y (1989) Gene 77:237

    Article  CAS  Google Scholar 

  143. Eikmanns BJ, Follettie MT, Girot MU, Sinskey AJ (1989) Mol Gen Genet 218:330

    Article  CAS  Google Scholar 

  144. von der Osten CH, Barbas CF, Wong CH, Sinskey AJ (1989) Mol Microbiol 3:1625

    Article  Google Scholar 

  145. Eikmanns BJ (1992) J Bacteriol 174:6076

    CAS  Google Scholar 

  146. Eikmanns BJ, Rittmann D, Sahm H (1995) J Bacteriol 177:774

    CAS  Google Scholar 

  147. Usuda Y, Tujimoto N, Abe C, Asakura Y, Kimura E, Kawahara Y, Kurahashi O, Matsui H (1996) Microbiology 142:3347

    CAS  Google Scholar 

  148. Peters-Wendisch PG, Kreutzer C, Kalinowski J, Pátek M, Sahm H, Eikmanns BJ (1997) Microbiology 144:915

    Article  Google Scholar 

  149. Ikeda M, Kamada N, Takano Y, Nakano T (1999) Biosci Biotechnol Biochem 63:1806

    Article  CAS  Google Scholar 

  150. Nakagawa S, Mizoguchi H, Ando S, Hayashi M, Hattori M, Shiba T, Sakaki Y, Yokoi H, Ozaki A (2000) Genomes 2000: International conference on microbial and model genomes, Paris, p 36

    Google Scholar 

  151. Frost JW (1992) US Patent 5 168 056

    Google Scholar 

  152. Backman KC (1992) US Patent 5 169 768

    Google Scholar 

  153. Koehn SJ, Evans TM, Nelson RA, Taylor PP(1994) WO9 428 154

    Google Scholar 

  154. Liao JC (1996) WO9 608 567

    Google Scholar 

  155. Sprenger G, Siewe R, Sahm H, Karutz M, Sonke T (1998) WO9 818 936

    Google Scholar 

  156. Sprenger G, Siewe R, Sahm H, Karutz M, Sonke T (1998) WO9 818 937

    Google Scholar 

  157. Patnaik R, Liao JC (1994) Appl Environ Microbiol 60:3903

    CAS  Google Scholar 

  158. Ikeda M, Katsumata R (1994) J Ferment Bioeng 78:420

    Article  CAS  Google Scholar 

  159. Sumantran VN, Schweizer HP, Datta P (1990) JBacteriol 172:4288

    CAS  Google Scholar 

  160. Reinscheid DJ, Kronemeyer W, Eggeling L, Eikmanns BJ, Sahm H (1994) Appl Environ Microbiol 60:126

    CAS  Google Scholar 

  161. Palmieri L, Berns D, Krämer R, Eikmanns M (1996) Arch Microbiol 165:48

    Article  CAS  Google Scholar 

  162. Krämer R (1994) Arch Microbiol 162:1

    Article  Google Scholar 

  163. Krämer R, Boles E, Eggeling L, Erdmann A, Gutmann M, Kronemeyer W, Palmieri L, Zittrich S (1994) Biochim Biophys Acta 1187:245

    Article  Google Scholar 

  164. Vrljic M, Kronemeyer W, Sahm H, Eggeling L (1995) JBacteriol 177:4021

    CAS  Google Scholar 

  165. Vrljic M, Sahm H, Eggeling L (1996) Mol Microbiol 22:815

    Article  CAS  Google Scholar 

  166. Aleshin VV, Zakataeva NP, Livshits VA (1999) Trends Biochem Sci 24:133

    Article  CAS  Google Scholar 

  167. Zakataeva NP, Aleshin VV, Tokmakova IL, Troshin PV, Livshits VA (1999) FEBS Lett 452:228

    Article  CAS  Google Scholar 

  168. Leinfelder W, Winterhalter C (1999) Japan Patent 11 056 381 A

    Google Scholar 

  169. Russell JB, Cook GM (1995) Microbiol Rev 59:48

    CAS  Google Scholar 

  170. Yokota A, Terasawa Y, Takaoka N, Shimizu H, Tomita F (1994) Biosci Biotechnol Biochem 58:2164

    Article  CAS  Google Scholar 

  171. Kalinowski J, Cremer J, Bachmann B, Eggeling L, Sahm H, Pühler A (1991) Mol Microbiol 5:1197

    Article  CAS  Google Scholar 

  172. Omori K, Suzuki S, Imai Y, Komatsubara S (1992) J Gen Microbiol 138:693

    CAS  Google Scholar 

  173. Omori K, Suzuki S, Imai Y, Komatsubara S (1993) J Bacteriol 175:785

    CAS  Google Scholar 

  174. Sugimoto M, Ogawa Y, Suzuki T, Tanaka A, Matsui H (1994) Japan Patent 6 062 866 A

    Google Scholar 

  175. Sugimoto M, Suzuki T, Matsui H (1996) Japan Patent 8 070 860 A

    Google Scholar 

  176. Kikuchi Y, Tsujimoto K, Kurahashi O (1997) Appl Environ Microbiol 63:761

    CAS  Google Scholar 

  177. Nakamori S, Kobayashi S, Nishimura T, Takagi H (1999) Appl Microbiol Biotechnol 52:179

    Article  CAS  Google Scholar 

  178. Nakagawa S, Mizoguchi H, Ando S, Hayashi M, Ochiai K, Yokoi H, Tateishi N, Senoh A, Ikeda M, Ozaki A (2001) Eur Patent 1 108 790

    Google Scholar 

  179. Ohnishi J, Mitsuhashi S, Hayashi M, Ando S, Yokoi H, Ochiai K, Ikeda M (2002) Appl Microbiol Biotechnol 58:217

    Article  CAS  Google Scholar 

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Ikeda, M. (2003). Amino Acid Production Processes. In: Faurie, R., et al. Microbial Production of l-Amino Acids. Advances in Biochemical Engineering/Biotechnology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45989-8_1

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  • DOI: https://doi.org/10.1007/3-540-45989-8_1

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