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Tumour Markers in Andrology

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Andrology for the Clinician

Summary

Prostate specific antigen (PSA), α-fetoprotein (AFP) and human chorionic gonadotrophin (hCG) are important circulating tumour markers in the management of prostatic and testicular carcinomas. Their success is due to an attractive combination of sensitivity and specificity, ranking them among the best tools available in the clinical laboratory for the detection and therapeutic follow-up of these tumours. PSA, a member of the kallikrein superfamily with high specificity for the prostate, is probably the best circulating tumour marker available. Its performance is expected to be improved by introducing new methods into the clinical laboratory to assess PSA subfractions and other kallikreins, and by the application of artificial neural networks that integrate classic and new markers towards a powerful clinical output. While both AFP and hCG are useful for the follow-up of non-seminoma germ cell tumours of the testis, only hCG performs well in seminomas. New trends are set by technologies such as proteomics analysis of serum and polymerase chain reactions (PCR) to detect circulating cancer cells via their unique marker expression profiles.

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Authors and Affiliations

  1. Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    M. E. Bracke

  2. Laboratory Nuytinck, Reibroekstraat 13, 9940, Evergem, Belgium

    M. E. Bracke

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  1. M. E. Bracke
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Editors and Affiliations

  1. Center of Dermatology and Andrology, Justus Liebig University Giessen, Gaffystraße 14, 35385, Giessen, Germany

    Wolf-Bernhard Schill

  2. Center for Medical and Urological Andrology and Reproductive Endocrinology, University Hospital Ghent 6K12IE, De Pintelaan 185, 9000, Ghent, Belgium

    Frank Comhaire

  3. Department of Oncology, University of Edinburgh, Western General Hospital, Human Genetics Building, Edinburgh, EH4 2XU, Scotland UK

    Timothy B. Hargreave

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© 2006 Springer-Verlag Berlin Heidelberg

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Bracke, M.E. (2006). Tumour Markers in Andrology. In: Schill, WB., Comhaire, F., Hargreave, T.B. (eds) Andrology for the Clinician. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-33713-X_76

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  • DOI: https://doi.org/10.1007/3-540-33713-X_76

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