Skip to main content

Hormonal and Stromal Regulation of Normal and Neoplastic Prostatic Growth

  • Chapter
Developmental Biology of Neoplastic Growth

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 40))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams JY, Leav I, Lau KM, Ho SM, Pflueger SM (2002) Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate. Prostate 52:69–81

    Article  PubMed  Google Scholar 

  • Arbeit JM, Munger K, Howley PM, Hanahan D (1994) Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol 68:4358–4368

    PubMed  Google Scholar 

  • Basset P, Wolf C, Chambon P (1993) Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review. Breast Cancer Res Treat 24:185–193

    Article  PubMed  Google Scholar 

  • Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2:737–744

    Article  PubMed  Google Scholar 

  • Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young P, Norton CR, Gridley T, Cardiff RD, Cunha GR, Abate-Shen C, Shen MM (1999) Roles for Nkx3.1 in prostate development and cancer. Genes Dev 13:966–977

    PubMed  Google Scholar 

  • Billingham R, Orr J, Woodhouse D (1951) Transplantation of skin components during chemical carcinogenesis with 20-methylcholanthrene. Br J Cancer 5:417–432

    PubMed  Google Scholar 

  • Bissell MJ, Hall HG (1987) Form and function in the mammary gland: The role of extracellular matrix. In: Neville MC, Daniel CW (eds) The mammary gland: development, regulation, and function. Plenum Press, New York, pp 97–146

    Google Scholar 

  • Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OM (2002) The organizing principal: microenvironmental influences in the normal and malignant breast. Differentiation 60:537–546

    Article  Google Scholar 

  • Bosman FT, de Bruine A, Flohil C, van der Wurff A, ten Kate J, Dinjens WW (1993) Epithelial-stromal interactions in colon cancer. Int J Dev Biol 37:203–211

    PubMed  Google Scholar 

  • Brauchle M, Angermeyer K, Hubner G, Werner S (1994) Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene 9:3199–3204

    PubMed  Google Scholar 

  • Brendler CB, Berry SJ, Ewing LL, McCullough AR, Cochran RC, Strandberg JD, Zirkin BR, Coffey DS, Wheaton LG, Hiler ML, Bordy MJ, Niswender GD, Scott WW, Walsh PC (1983) Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate. J Clin Invest 71:1114–1123

    PubMed  Google Scholar 

  • Buchanan DL, Kurita T, Taylor JA, Lubahn DL, Cunha GR, Cooke PS (1998a) Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification and cornification. Endocrinology 139:4345–4352

    Article  PubMed  Google Scholar 

  • Buchanan DL, Setiawan T, Lubahn DL, Taylor JA, Kurita T, Cunha GR, Cooke PS (1998b) Tissue compartment-specific estrogen receptor participation in the mouse uterine epithelial secretory response. Endocrinology 140:484–491

    Article  Google Scholar 

  • Camps JL, Chang SM, Hsu TC, Freeman MR, Hong SJ, Zhau HE, von Eschenbach AC, Chung LW (1990) Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci USA 87:75–79

    PubMed  Google Scholar 

  • Chang WY, Wilson MJ, Birch L, Prins GS (1999) Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate. Endocrinology 140:405–415

    Article  PubMed  Google Scholar 

  • Chaudhuri S, Koprowska I, Rowinski J (1975) Different agglutinability of fibroblasts underlying various precursor lesions of human uterine cervical carcinoma. Cancer Res 35:2350–2354

    PubMed  Google Scholar 

  • Chiquet-Ehrismann R, Mackie EJ, Pearson CA, Sakakura T (1986) Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell 47:131–139

    Article  PubMed  Google Scholar 

  • Chung LW, Chang SM, Bell C, Zhau HE, Ro JY, von Eschenbach AC (1989) Co-inoculation of tumorigenic rat prostate mesenchymal cells with non-tumorigenic epithelial cells results in the development of carcinosarcoma in syngeneic and athymic animals. Int J Cancer 43:1179–1187

    PubMed  Google Scholar 

  • Cohen RJ, Glezerson G, Taylor LF, Grundle HA, Naude JH (1993) The neuroendocrine cell population of the human prostate gland. J Urol 150:365–368

    PubMed  Google Scholar 

  • Cooke P, Buchanan D, Young P, Setiawan T, Brody J, Korach K, Taylor J, Lubahn D, Cunha G (1997) Stromal estrogen receptors (ER) mediate mitogenic effects of estradiol on uterine epithelium. Proc Natl Acad Sci USA 94:6535–6540

    Article  PubMed  Google Scholar 

  • Cooke PS, Young P, Cunha GR (1991a) Androgen receptor expression in developing male reproductive organs. Endocrinology 128:2867–2873

    PubMed  Google Scholar 

  • Cooke PS, Young P, Hess RA, Cunha GR (1991b) Estrogen receptor expression in developing epididymis, efferent ductules and other male reproductive organs. Endocrinology 128:2874–2879

    PubMed  Google Scholar 

  • Cooper M, Pinkus H (1977) Intrauterine transplantation of rat basal cell carcinoma: a model for reconversion of malignant to benign growth. Cancer Res 37:2544–2552

    PubMed  Google Scholar 

  • Cornil I, Theodorescu D, Man S, Herlyn M, Jambrosic J, Kerbel RS (1991) Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression. Proc Natl Acad Sci USA 88:6028–6032

    PubMed  Google Scholar 

  • Couse JF, Korach KS (1999) Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358–417

    Article  PubMed  Google Scholar 

  • Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS (1997) Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology 138:4613–4621

    Article  PubMed  Google Scholar 

  • Coussens LM, Hanahan D, Arbeit JM (1996) Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. Am J Pathol 149:1899–1917

    PubMed  Google Scholar 

  • Cunha GR (1972) Epithelio-mesenchymal interactions in primordial gland structures which become responsive to androgenic stimulation. Anat Rec 172:179–196

    Article  PubMed  Google Scholar 

  • Cunha GR (1984) Androgenic effects upon prostatic epithelium are mediated via trophic influences from stroma. In: Kimball FA, Buhl AE, Carter DB (eds) New approaches to the study of benign prostatic hyperplasia. Liss, New York, pp 81–102

    Google Scholar 

  • Cunha GR (1994) Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate. Cancer 74:1030–1044

    PubMed  Google Scholar 

  • Cunha GR, Young P (1991) Inability of Tfm (testicular feminization) epithelial cells to express androgen-dependent seminal vesicle secretory proteins in chimeric tissue recombinants. Endocrinology 128:3293–3298

    PubMed  Google Scholar 

  • Cunha GR, Reese BA, Sekkingstad M (1980) Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice. Endocrinology 107:1767–1770

    PubMed  Google Scholar 

  • Cunha GR, Fujii H, Neubauer BL, Shannon JM, Sawyer LM, Reese BA (1983a) Epithelialmesenchymal interactions in prostatic development. I. Morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. J Cell Biol 96:1662–1670

    Article  PubMed  Google Scholar 

  • Cunha GR, Sekkingstad M, Meloy BA (1983b) Heterospecific induction of prostatic development in tissue recombinants prepared with mouse, rat, rabbit, and human tissues. Differentiation 24:174–180

    PubMed  Google Scholar 

  • Cunha GR, Donjacour AA, Cooke PS, Mee S, Bigsby RM, Higgins SJ, Sugimura Y (1987) The endocrinology and developmental biology of the prostate. Endocr Rev 8:338–362

    PubMed  Google Scholar 

  • Cunha GR, Alarid ET, Turner T, Donjacour AA, Boutin EL, Foster BA (1992) Normal and abnormal development of the male urogenital tract: role of androgens, mesenchymalepithelial interactions and growth factors. J Androl 13:465–475

    PubMed  Google Scholar 

  • Cunha GR, Hayward SW, Wang Y-Z (2002) Role of stroma in carcinogenesis of the prostate. Differentiation 60:473–485

    Article  Google Scholar 

  • Cunha GR, Hayward SW, Wang YZ, Ricke WA (2003) Role of the stromal microenvironment in carcinogenesis of the prostate. Int J Cancer 107:1–10

    Article  PubMed  Google Scholar 

  • Dawe CJ (1972) Epithelial-mesenchymal interactions in relation to the genesis of polyoma virus-induced tumours of mouse salivary gland. In: Tarin D (ed) Tissue interactions in carcinogenesis. Academic Press, London, pp 305–358

    Google Scholar 

  • De Cosse J, Gossens CL, Kuzma JF (1973) Breast cancer: induction of differentiation by embryonic tissue. Science 181:1057–1058

    PubMed  Google Scholar 

  • De Cosse JJ, Gossens CL, Kuzma JF, Unsworth BR (1975) Embryonic inductive tissues that cause histological differentiation of murine mammary carcinoma in vitro. J Natl Cancer Inst 54:913–921

    PubMed  Google Scholar 

  • Donjacour AA, Cunha GR (1988) Seminal vesicle mesenchyme induces prostatic morphology and secretion in urinary bladder epithelium. J Cell Biol 107:609a

    Google Scholar 

  • Donjacour AA, Cunha GR (1993) Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen-insensitive mice. Endocrinology 131: 2342–2350

    Article  Google Scholar 

  • Donjacour AA, Cunha GR (1995) Induction of prostatic morphology and secretion in urothelium by seminal vesicle mesenchyme. Development 121:2199–2207

    PubMed  Google Scholar 

  • Donjacour AA, Thomson AA, Cunha GR (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol 261:39–54

    Article  PubMed  Google Scholar 

  • Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161–174

    Article  PubMed  Google Scholar 

  • Ellis MJ, Singer C, Hornby A, Rasmussen A, Cullen KJ (1994) Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer. Breast Cancer Res Treat 31:249–261

    PubMed  Google Scholar 

  • Foster BA, Gingrich JR, Kwon ED, Madias C, Greenberg NM (1997) Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Cancer Res 57:3325–3330

    PubMed  Google Scholar 

  • Foster BA, Evangelou A, Gingrich JR, Kaplan PJ, DeMayo F, Greenberg NM (2002) Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice. Differentiation 60:624–632

    Article  Google Scholar 

  • Frazier KS, Grotendorst GR (1997) Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors. Int J Biochem Cell Biol 29:153–161

    Article  PubMed  Google Scholar 

  • Fujii H, Cunha GR, Norman JT (1982) The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor. J Urol 128:858–861

    PubMed  Google Scholar 

  • Fukamachi H, Mizuno T, Kim YS (1986) Morphogenesis of human colon cancer cells with fetal rat mesenchymes in organ culture. Experientia 42:312–315

    Article  PubMed  Google Scholar 

  • Fukamachi H, Mizuno T, Kim YS (1987) Gland formation of human colon cancer cells combined with foetal rat mesenchyme in organ culture: an ultrastructural study. J Cell Sci 87:615–621

    PubMed  Google Scholar 

  • Gabbert H (1985) Mechanisms of tumor invasion: evidence from in vivo observations. Cancer Metastasis Rev 4:293–309

    Article  PubMed  Google Scholar 

  • Gao J, Arnold JT, Isaacs JT (2001) Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Cancer Res 61:5038–5044

    PubMed  Google Scholar 

  • Gregoire M, Lieubeau B (1995) The role of fibroblasts in tumor behavior. Cancer Metastasis Rev 14:339–350

    Article  PubMed  Google Scholar 

  • Hayashi N, Cunha GR (1991) Mesenchyme-induced changes in neoplastic characteristics of the Dunning prostatic adenocarcinoma. Cancer Res 51:4924–4930

    PubMed  Google Scholar 

  • Hayashi N, Cunha GR, Wong YC (1990) Influence of male genital tract mesenchymes on differentiation of Dunning prostatic adenocarcinoma. Cancer Res 50:4747–4754

    PubMed  Google Scholar 

  • Hayashi N, Cunha GR, Parker M (1993) Permissive and instructive induction of adult rodent prostatic epithelium by heterotypic urogenital sinus mesenchyme. Epithelial Cell Biol 2:66–78

    PubMed  Google Scholar 

  • Hayashi N, Tsuji M, Sugimura Y, Kawamura J, Cunha GR (1996) Change in the morphological and functional cytodifferentiation induced by seminal vesicle mesenchyme in cell suspensions of rat Dunning prostatic adenocarcinoma cells. Int J Cancer 68:788–794

    Article  PubMed  Google Scholar 

  • Hayes RB, de Jong FH, Raatgever J, Bogdanovicz J, Schroeder FH, van der Maas P, Oishi K, Yoshida O (1992) Physical characteristics and factors related to sexual development and behaviour and the risk for prostatic cancer. Eur J Cancer Prev 1:239–245

    PubMed  Google Scholar 

  • Hayward S, Wang Y, Cao M, Hom Y, Zhang B, Grossfeld G, Sudilovsky D, Cunha G (2001) Malignant transformation in a non-tumorigenic human prostatic epithelial cell line. Cancer Res 61:8135–8142

    PubMed  Google Scholar 

  • Hayward SW, Baskin LS, Haughney PC, Cunha AR, Foster BA, Dahiya R, Prins GS, Cunha GR (1996a) Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle. Acta Anat 155:81–93

    PubMed  Google Scholar 

  • Hayward SW, Baskin LS, Haughney PC, Foster BA, Cunha AR, Dahiya R, Prins GS, Cunha GR (1996b) Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat. Acta Anat 155:94–103

    PubMed  Google Scholar 

  • Hayward SW, Cunha GR, Dahiya R (1996c) Normal development and carcinogenesis of the prostate: a unifying hypothesis. Ann NY Acad Sci 784:50–62

    PubMed  Google Scholar 

  • Hayward SW, Dahiya R, Cunha GR, Bartek J, Despande N, Narayan P (1995) Establishment and characterization of an immortalized but non-tumorigenic human prostate epithelial cell Line: BPH-1. In Vitro 31A:14–24

    Google Scholar 

  • Hayward SW, Rosen MA, Cunha GR (1997) Stromal-epithelial interactions in normal and neoplastic prostate. Br J Urol 79[Suppl 2]:18–26

    PubMed  Google Scholar 

  • Hayward SW, Haughney PC, Rosen MA, Greulich KM, Weier HU, Dahiya R, Cunha GR (1998) Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model. Differentiation 63:131–140

    PubMed  Google Scholar 

  • Higgins SJ, Young P, Brody JR, Cunha GR (1989) Induction of functional cytodifferentiation in the epithelium of tissue recombinants. I. Homotypic seminal vesicle recombinants. Development 106:219–234

    PubMed  Google Scholar 

  • Ingber DE, Jamieson JD (1982) Tumor formation and malignant invasion: role of basal lamina. In: Liotta L, Hart I (eds) Tumor invasion and metastasis. Nijhoff, The Hague, pp 335–357

    Google Scholar 

  • Isaacs JT (1984) Antagonistic effect of androgen on prostatic cell death. Prostate 5:545–557

    PubMed  Google Scholar 

  • Itoh T, Tanioka M, Yoshida H, Yoshioka T, Nishimoto H, Itohara S (1998) Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res 58:1048–1051

    PubMed  Google Scholar 

  • Itoh T, Tanioka M, Matsuda H, Nishimoto H, Yoshioka T, Suzuki R, Uehira M (1999) Experimental metastasis is suppressed in MMP-9-deficient mice. Clin Exp Metastasis 17:177–181

    Article  PubMed  Google Scholar 

  • Kinbara H, Cunha GR (1995) Ductal heterogeneity in rat dorsal-lateral prostate. Prostate 28:58–64

    Article  Google Scholar 

  • Krtolica A, Campisi J (2002) Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 34:1401–1414

    Article  PubMed  Google Scholar 

  • Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925–5930

    Article  PubMed  Google Scholar 

  • Kurita T, Young P, Brody J, Lydon JP, O'Malley BW, Cunha GR (1998) Stromal progesterone receptors mediate the inhibitory effects of progesterone on estrogen-induced uterine epithelial cell (UtE) proliferation. Endocrinology 139:4708–4713

    Article  PubMed  Google Scholar 

  • Kurita T, Wang Y-Z, Donjacour AA, Zhao C, Lydon JP, O'Malley BP, Isaacs JT, Dahiya R, Cunha GR (2001) Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ 8:192–200

    Article  PubMed  Google Scholar 

  • Kurita T, Medina RT, Mills AA, Cunha GR (2004) Role of p63 and basal cells in the prostate. Development 131:4955–4964

    Article  PubMed  Google Scholar 

  • Kyprianou N, Bruckheimer EM, Guo Y (2000) Cell proliferation and apoptosis in prostate cancer: significance in disease progression and therapy. Histol Histopathol 15:1211–1223

    PubMed  Google Scholar 

  • Lau KM, Leav I, Ho SM (1998) Rat estrogen receptor-alpha and-beta, and progesterone receptor mRNA expression in various prostatic lobes and microdissected normal and dysplastic epithelial tissues of the Noble rats. Endocrinology 139:424–427

    Article  PubMed  Google Scholar 

  • Lee C (1981) Physiology of castration-induced regression in rat prostate. In: Karr JP, Sandberg AA, Murphy GP (eds) The prostatic cell: structure and function, part A. Liss, New York, pp 145–159

    Google Scholar 

  • Lee C, Sensibar JA, Dudek SM, Hiipakka RA, Liao ST (1990) Prostatic ductal system in rats: regional variation in morphological and functional activities. Biol Reprod 43:1079–1086

    Article  PubMed  Google Scholar 

  • Lipschutz JH, Fukami H, Yamamoto M, Tatematsu M, Sugimura Y, Kusakabe M, Cunha GR (1999) Clonality of urogenital organs as determined by analysis of chimeric mice. Cells Tissues Organs 165:57–66

    Article  PubMed  Google Scholar 

  • Lopes ES, Foster BA, Donjacour AA, Cunha GR (1996) Initiation of secretory activity of rat prostatic epithelium in organ culture. Endocrinology 137:4225–4234

    Article  PubMed  Google Scholar 

  • Lynch CC, Matrisian LM (2002) Matrix metalloproteinases in tumor-host cell communication. Differentiation 70:561–573

    Article  PubMed  Google Scholar 

  • Marker PC, Stephan JP, Lee J, Bald L, Mather JP, Cunha GR (2001) fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis. Dev Biol 233:95–108

    Article  PubMed  Google Scholar 

  • Marker PC, Donjacour AA, Dahiya R, Cunha GR (2003) Hormonal, cellular, and molecular control of prostatic development. Dev Biol 253:165–174

    Article  PubMed  Google Scholar 

  • Masson R, Lefebvre O, Noel A, Fahime ME, Chenard MP, Wendling C, Kebers F, LeMeur M, Dierich A, Foidart JM, Basset P, Rio MC (1998) In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J Cell Biol 140:1535–1541

    Article  PubMed  Google Scholar 

  • McGarvey TW, Stearns ME (1995) Keratinocyte growth factor and receptor mRNA expression in benign and malignant human prostate. Exp Mol Pathol 63:52–62

    Article  PubMed  Google Scholar 

  • McKeehan WL, Kan M, Hou J, Wang F, Adams P, Mansson P-E (1991) Heparin-binding (fibroblast) growth factor/receptor gene expression in the prostate. In: Karr J, Coffey DS, Smith RG, Tindall DJ (eds) Molecular and cell biology of prostate cancer. Plenum Press, New York, pp 115–126

    Google Scholar 

  • McKeehan WL, Wang F, Kan M (1998) The heparan sulfate-fibroblast growth factor family: diversity of structure and function. Prog Nucleic Acid Res Mol Biol 59:135–176

    PubMed  Google Scholar 

  • McNeal JE (1983) The prostate gland: morphology and pathobiology. Monogr Urol 4:3–37

    Google Scholar 

  • Moeller H, Blank B, Lander K, Mates G (1987) Ontogeny of the androgen receptor in rat ventral prostate during sexual development. Res Exp Med 187:287–294

    Article  Google Scholar 

  • Momose H, Uchida K, Kakinuma H, Yura Y, Oyasu R (1990) Involvement of urine in epithelial-stromal interactions in urinary bladder carcinogenesis. Cancer Lett 53:91–96

    Article  PubMed  Google Scholar 

  • Nakamura T, Matsumoto K, Kiritoshi A, Tano Y, Nakamura T (1997) Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res 57:3305–3313

    PubMed  Google Scholar 

  • Norman JT, Cunha GR, Sugimura Y (1986) The induction of new ductal growth in adult prostatic epithelium in response to an embryonic prostatic inductor. Prostate 8:209–220

    PubMed  Google Scholar 

  • Oishi K, Romijn JC, Schroeder FH (1981) The surface character of separated prostatic cells and cultured fibroblasts of prostatic tissue as determined by concanavalin-a hemadsorption. Prostate 2:11–21

    PubMed  Google Scholar 

  • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR (1999) Carcinomaassociated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59:5002–5011

    PubMed  Google Scholar 

  • Phillips J, Hayward S, Wang Y, Vasselli J, Pavlovich C, Padilla-Nash H, Pezullo J, Ghadimi B, Grossfeld G, Rivera A, Linehan W, Cunha G, Ried T (2001) The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. Cancer Res 61:8143–8149

    PubMed  Google Scholar 

  • Picard O, Rolland Y, Poupon MF (1986) Fibroblast-dependent tumorigenicity of cells in nude mice: implication for implantation of metastases. Cancer Res 46:3290–3294

    PubMed  Google Scholar 

  • Podlasek CA, Seo RM, Clemens JQ, Ma L, Maas RL, Bushman W (1999) Hoxa-10 deficient male mice exhibit abnormal development of the accessory sex organs. Dev Dyn 214:1–12

    Article  PubMed  Google Scholar 

  • Ponten F, Ren Z, Nister M, Westermark B, Ponten J (1994) Epithelial-stromal interactions in basal cell cancer: the PDGF system. J Invest Dermatol 102:304–309

    Article  PubMed  Google Scholar 

  • Price D (1963) Comparative aspects of development and structure in the prostate. Natl Cancer Inst Monogr 12:1–27

    PubMed  Google Scholar 

  • Prins G, Birch L (1995) The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen. Endocrinology 136:1303–1314

    Article  PubMed  Google Scholar 

  • Prins G, Birch L (1997) Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology 138:1801–1809

    Article  PubMed  Google Scholar 

  • Prins G, Birch L, Greene G (1991) Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology 129:3187–3199

    PubMed  Google Scholar 

  • Prins GS, Jung MH, Vellanoweth RL, Chatterjee B, Roy AK (1996) Age-dependent expression of the androgen receptor gene in the prostate and its implication in glandular differentiation and hyperplasia. Dev Genet 18:99–106

    Article  PubMed  Google Scholar 

  • Prins G, Marmer M, Woodham C, Chang W, Kuiper G, Gustafsson JA, Birch L (1998) Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats. Endocrinology 139:874–83

    Article  PubMed  Google Scholar 

  • Prins G, Birch L, Couse JF, Choi I, Katzenellenbogen B, Korach KS (2001) Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alpha-ERKO and beta-ERKO mice. Cancer Res 61:6089–6097

    PubMed  Google Scholar 

  • Pupa SM, Menard S, Forti S, Tagliabue E (2002) New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 192:259–267

    Article  PubMed  Google Scholar 

  • Redler P, Lustig ES (1968) Differences in the growth-promoting effect of normal and peritumoral dermis on epidermis in vitro. Dev Biol 17:679–691

    Article  PubMed  Google Scholar 

  • Risbridger G, Wang H, Frydenberg M, Cunha GR (2001a) The metaplastic effects of estrogen on prostate epithelium: proliferation of cells with basal cell phenotype. Endocrinology 142:2443–2450

    Article  PubMed  Google Scholar 

  • Risbridger G, Wang H, Young P, Kurita T, Wong Y, Lubahn D, Gustafsson J-A, Cunha G (2001b) Evidence that epithelial and mesenchymal estrogen receptor-a mediates effects of estrogen on prostatic epithelium. Dev Biol 229:432–442

    Article  PubMed  Google Scholar 

  • Ronnov-Jessen L, Petersen OW, Bissell MJ (1996) Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 76:69–125

    PubMed  Google Scholar 

  • Ross R, Bernstein L, Judd H, Hanisch R, Pike M, Henderson B (1986) Serum testosterone levels in healthy young black and white men. J Natl Cancer Inst 76:45–48

    PubMed  Google Scholar 

  • Schor SL, Schor AM, Rushton G (1988) Fibroblasts from cancer patients display a mixture of both foetal and adult-like phenotypic characteristics. J Cell Sci 90:401–407

    PubMed  Google Scholar 

  • Sciavolino PJ, Abrams EW, Yang L, Austenberg LP, Shen MM, Abate-Shen C (1997) Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev Dyn 209:127–138

    Article  PubMed  Google Scholar 

  • Seljelid R, Jozefowski S, Sveinbjornsson B (1999) Tumor stroma. Anticancer Res 19:4809–4822

    PubMed  Google Scholar 

  • Shattuck-Brandt RL, Lamps LW, Heppner-Goss KJ, DuBois RN, Matrisian LM (1999) Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. Mol Carcinog 24:177–187

    Article  PubMed  Google Scholar 

  • Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L, Yang A, Montironi R, McKeon F, Loda M (2000) p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 157:1769–1775

    PubMed  Google Scholar 

  • Singer C, Rasmussen A, Smith HS, Lippman ME, Lynch HT, Cullen KJ (1995) Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function. Cancer Res 55:2448–2454

    PubMed  Google Scholar 

  • Staack A, Donjacour AA, Brody J, Cunha GR, Carroll P (2003) Mouse urogenital development: a practical approach. Differentiation 71:402–413

    Article  PubMed  Google Scholar 

  • Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ, Werb Z (1999) The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98:137–146

    Article  PubMed  Google Scholar 

  • Sugimura Y, Cunha GR, Bigsby RM (1986a) Androgenic induction of deoxyribonucleic acid synthesis in prostatic glands induced in the urothelium of testicular feminized (Tfm/y) mice. Prostate 9:217–225

    PubMed  Google Scholar 

  • Sugimura Y, Cunha GR, Donjacour AA (1986b) Morphogenesis of ductal networks in the mouse prostate. Biol Reprod 34:961–971

    Article  PubMed  Google Scholar 

  • Takeda H, Chang C (1991) Immunohistochemical and in situ hybridization analysis of androgen receptor expression during the development of the mouse prostate gland. J Endocrinol 129:83–89

    PubMed  Google Scholar 

  • Tam NNC, Phil M, Wang YZ, Wong YC (1997) The influence of mesenchyme of neonatal seminal vesicle and embryonic urogenital sinus on the morphologic and functional cytodifferentiation of Dunning prostatic adenocarcinoma: roles of growth factors and proto-oncogenes. Urol Oncol 3:85–93

    Google Scholar 

  • Tarin D (1972) Tissue Interactions in Carcinogenesis. Academic Press, London, 483 pp

    Google Scholar 

  • Thomson AA (2001) Role of androgens and fibroblast growth factors in prostatic development. Reproduction 121:187–195

    Article  PubMed  Google Scholar 

  • Thyberg J (1996) Differentiated properties and proliferation of arterial smooth muscle cells in culture. Int Rev Cytol 169:183–265

    PubMed  Google Scholar 

  • Timms BG, Mohs TJ, DiDio JA (1994) Ductal budding and branching patterns in the developing prostate. J Urol 151:1427–1432

    PubMed  Google Scholar 

  • Turner MA, Darragh T, Palefsky JM (1997) Epithelial-stromal interactions modulating penetration of matrigel membranes by HPV 16-immortalized keratinocytes. J Invest Dermatol 109:619–625

    Article  PubMed  Google Scholar 

  • Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR (2002) Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model. Cancer Res 62:3298–3307

    PubMed  Google Scholar 

  • Uchida K, Samma S, Momose H, Kashihara N, Rademaker A, Oyasu R (1990) Stimulation of urinary bladder tumorigenesis by carcinogen-exposed stroma. J Urol 143:618–621

    PubMed  Google Scholar 

  • Van Kempen LCL, Rhee J-S, Dehne K, Lee J, Edwards DR, Coussens LM (2002) Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment. Differentiation 60:610–623

    Article  Google Scholar 

  • Walsh PC (1975) Physiologic basis for hormonal therapy in carcinoma of the prostate. Urol Clin North Am 2:125–131

    PubMed  Google Scholar 

  • Wang Y, Hayward S, Cao M, Thayer K, Cunha G (2001a) Cell differentiation lineage in the prostate. Differentiation 68:270–279

    Article  PubMed  Google Scholar 

  • Wang Y, Hayward SW, Donjacour AA, Young P, Jacks T, Sage J, Dahiya R, Cardiff R, Day ML, Cunha GR (2000) Hormonal carcinogenesis of the Rb-knockout mouse prostate. Cancer Res 60:6008–6017

    PubMed  Google Scholar 

  • Wang Y, Sudilovsky D, Zhang B, Haughney PC, Rosen MA, Wu DS, Cunha TJ, Dahiya R, Cunha GR, Hayward SW (2001b) A human prostatic epithelial model of hormonal carcinogenesis. Cancer Res. 61:6064–6072

    PubMed  Google Scholar 

  • Wang YZ, Hayward SW, Cao M, Young P, Cardiff R, Cunha G (2001c) Role of estrogen signaling in prostatic hormonal carcinogenesis. J Urol 165:1320

    Google Scholar 

  • Weihua Z, Makela S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA (2001) A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 98:6330–6335

    Article  PubMed  Google Scholar 

  • Werb Z, Ashkenas J, MacAuley A, Wiesen JF (1996) Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis. Braz J Med Biol Res 29:1087–1097

    Google Scholar 

  • Wilson CL, Heppner KJ, Labosky PA, Hogan BL, Matrisian LM (1997) Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci USA 94:1402–1407

    Article  PubMed  Google Scholar 

  • Wong YC, Tam NNC (2002) Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesis. Differentiation 60:633

    Article  Google Scholar 

  • Wong YC, Cunha GR, Hayashi N (1992) Effects of mesenchyme of embryonic urogenital sinus and neonatal seminal vesicle on the cytodifferentiation of the Dunning tumor: ultrastructural study. Acta Anat 143:139–150

    PubMed  Google Scholar 

  • Wright JH, McDonnell S, Portella G, Bowden GT, Balmain A, Matrisian LM (1994) A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression. Mol Carcinog 10:207–215

    PubMed  Google Scholar 

  • Xue Y, van der Laak J, Smedts F, Schoots C, Verhofstad A, de la Rosette J, Schalken J (2000) Neuroendocrine cells during human prostate development: does neuroendocrine cell density remain constant during fetal as well as postnatal life? Prostate 42:116–123

    Article  PubMed  Google Scholar 

  • Yan G, Fukabori Y, Nikolaropoulos S, Wang F, McKeehan WL (1992) Heparin-binding keratinocyte growth factor is a candidate stromal to epithelial cell andromedin. Mol Endocrinol 6:2123–2128

    Article  PubMed  Google Scholar 

  • Yan G, Fukabori Y, McBride G, Nikolaropoulos S, McKeehan W (1993) Exon switching and activation of stromal and embryonic FGF/FGF receptor genes in prostate epithelial cells accompanies stromal independence and malignancy. Mol Cell Biol 13:4513–4522

    PubMed  Google Scholar 

  • Yee D, Paik S, Lebovic GS, Marcus RR, Favoni RE, Cullen KJ, Lippman ME, Rosen N (1989) Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol 3:509–517

    PubMed  Google Scholar 

  • Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C (2002) Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci USA 99:13498–13503

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ricke, W., Wang, Y., Kurita, T., Hayward, S., Cunha, G. (2005). Hormonal and Stromal Regulation of Normal and Neoplastic Prostatic Growth. In: Macieira-Coelho, A. (eds) Developmental Biology of Neoplastic Growth. Progress in Molecular and Subcellular Biology, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27671-8_8

Download citation

Publish with us

Policies and ethics