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Omics Approaches in Sleep-Wake Regulation

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Sleep-Wake Neurobiology and Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 253))

Abstract

Although sleep seems an obvious and simple behaviour, it is extremely complex involving numerous interactions both at the neuronal and the molecular levels. While we have gained detailed insight into the molecules and neuronal networks responsible for the circadian organization of sleep and wakefulness, the molecular underpinnings of the homeostatic aspect of sleep regulation are still unknown and the focus of a considerable research effort. In the last 20 years, the development of techniques allowing the simultaneous measurement of hundreds to thousands of molecular targets (i.e. ‘omics’ approaches) has enabled the unbiased study of the molecular pathways regulated by and regulating sleep. In this chapter, we will review how the different omics approaches, including transcriptomics, epigenomics, proteomics, and metabolomics, have advanced sleep research. We present relevant data in the framework of the two-process model in which circadian and homeostatic processes interact to regulate sleep. The integration of the different omics levels, known as ‘systems genetics’, will eventually lead to a better understanding of how information flows from the genome, to molecules, to networks, and finally to sleep both in health and disease.

Emma K. O’Callaghan and Edward W. Green contributed equally to this work.

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Acknowledgements

The authors want to thank M. Freyburger, R. Massart, L. Boureau, and A. Blanchet-Cohen for their help in producing the data included in Fig. 2.

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    Authors and Affiliations

    1. Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada

      Emma K. O’Callaghan & Valérie Mongrain

    2. Department of Neuroscience, Université de Montréal, Montreal, QC, Canada

      Emma K. O’Callaghan & Valérie Mongrain

    3. German Cancer Research Center (DKFZ), Heidelberg, Germany

      Edward W. Green

    4. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

      Paul Franken

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    1. Emma K. O’Callaghan
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    2. Edward W. Green
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    3. Paul Franken
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    4. Valérie Mongrain
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    Correspondence to Valérie Mongrain .

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    Editors and Affiliations

    1. Human Sleep Psychopharmacology Laboratory, Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland

      Hans-Peter Landolt

    2. Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

      Derk-Jan Dijk

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    O’Callaghan, E.K., Green, E.W., Franken, P., Mongrain, V. (2018). Omics Approaches in Sleep-Wake Regulation. In: Landolt, HP., Dijk, DJ. (eds) Sleep-Wake Neurobiology and Pharmacology . Handbook of Experimental Pharmacology, vol 253. Springer, Cham. https://doi.org/10.1007/164_2018_125

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