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Organ-Specific Cancer Metabolism and Its Potential for Therapy

  • Chapter
Metabolic Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 233))

Abstract

Targeting cancer metabolism has the potential to lead to major advances in tumor therapy. Numerous promising metabolic drug targets have been identified. Yet, it has emerged that there is no singular metabolism that defines the oncogenic state of the cell. Rather, the metabolism of cancer cells is a function of the requirements of a tumor. Hence, the tissue of origin, the (epi)genetic drivers, the aberrant signaling, and the microenvironment all together define these metabolic requirements. In this chapter we discuss in light of (epi)genetic, signaling, and environmental factors the diversity in cancer metabolism based on triple-negative and estrogen receptor-positive breast cancer, early- and late-stage prostate cancer, and liver cancer. These types of cancer all display distinct and partially opposing metabolic behaviors (e.g., Warburg versus reverse Warburg metabolism). Yet, for each of the cancers, their distinct metabolism supports the oncogenic phenotype. Finally, we will assess the therapeutic potential of metabolism based on the concepts of metabolic normalization and metabolic depletion.

*Equal contributing authors.

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Acknowledgments

We would like to thank Jörg Büscher, Peter Carmeliet, Katrien De Bock, Mark Keibler, and Sophia Lunt for thoughtful discussions and critical reading of the manuscript. SMF acknowledges support from Marie Curie CIG, FWO-Odysseus II, Concern Foundation, and Bayer HealthCare Pharmaceuticals.

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    1. Vesalius Research Center, VIB, 3000, Leuven, Belgium

      Ilaria Elia, Roberta Schmieder, Stefan Christen & Sarah-Maria Fendt

    2. Department of Oncology, KU Leuven, 3000, Leuven, Belgium

      Ilaria Elia, Roberta Schmieder, Stefan Christen & Sarah-Maria Fendt

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    1. Helmholtz Center Munich, and Heidelberg University Hospital, Professor and Director, Institute for Diabetes and Cancer IDC, and Joint Heidelberg-IDC Translational Diabetes Program, Neuherberg, Germany

      Stephan Herzig

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    Elia, I., Schmieder, R., Christen, S., Fendt, SM. (2015). Organ-Specific Cancer Metabolism and Its Potential for Therapy. In: Herzig, S. (eds) Metabolic Control. Handbook of Experimental Pharmacology, vol 233. Springer, Cham. https://doi.org/10.1007/164_2015_10

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