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Conformation of Glycopeptides and Glycoproteins

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Glycopeptides and Glycoproteins

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 267))

Abstract

Glycosylation is the most frequent post-translational modification found in proteins. Glycoproteins are involved in a highly diverse spectrum of biological functions, ranging from protein folding and molecular and cellular recognition to attack of pathogens and regulation of biological half-life. Consequently, understanding the structural role of glycosylation provides key insight into biological processes as well as ideas for medicinal applications. Here, we review the current methodology to arrive at high-resolution structures of glycopeptides and glycoproteins. To achieve this, significant obstacles have to be overcome like preparation of sufficient amounts of sufficiently pure and homogeneous material, analyzing highly ambiguous spectroscopic data, and dealing with molecules that show local or global disorder. We will provide an overview of our knowledge of glycoprotein and glycopeptide structure, and illustrate with selected examples the performance and limitations of current methodology.

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Abbreviations

AFGPs:

antifreeze glycoproteins

BEVS:

baculovirus expression vectors

BMRB:

BioMagResBank

CCR:

cross-correlated relaxation

CCSD:

Complex Carbohydrate Structure Database

CD:

circular dichroism

CFG:

Consortium for Functional Glycomics

EPL:

expressed protein ligation

GalT:

galactosyltransferase

GnT:

glucosaminyltransferase

hCG:

human chorionic gonadotropin

HMBC:

heteronuclear multiple-bond correlation

IgSF:

immune globulin superfamily

Kdo:

3-deoxy-D-manno-octulosonic acid

KEGG:

Kyoto Encyclopedia of Genes and Genomes

Ley-Antigen:

Lewisy-antigen

MAS:

magic angle spinning

MD:

molecular dynamics

NCL:

native chemical ligation

NMR:

nuclear magnetic resonance

NOE:

nuclear Overhauser enhancement

PDB:

Protein Data Bank

RDCs:

residual dipolar couplings

SPPS:

solid-phase peptide synthesis

SPR:

surface plasmon resonance

ST:

sialyltransferase

STF-Antigen:

sialyl-Thomsen-Friedenreich-antigen

TF-Antigen:

Thomsen-Friedenreich-antigen, Galβ1-3GalNAcα1-O-Ser/Thr

Tn-Antigen:

Thomsen-antigen, GalNAcα1-O-Ser/Thr

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Authors and Affiliations

  1. Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, 20146, Hamburg, Germany

    Bernd Meyer

  2. Fachbereich Chemie, Universität Konstanz, Universitätsstraße 10, 78457, Konstanz, Germany

    Heiko Möller

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  1. Bernd Meyer
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  2. Heiko Möller
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Correspondence to Heiko Möller .

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Valentin Wittmann

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© 2006 Springer-Verlag Berlin Heidelberg

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Meyer, B., Möller, H. (2006). Conformation of Glycopeptides and Glycoproteins. In: Wittmann, V. (eds) Glycopeptides and Glycoproteins. Topics in Current Chemistry, vol 267. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2006_078

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