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Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics

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Aptamers in Biotechnology

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 174))

Abstract

Defining target product profiles (TPPs) for aptamer-based diagnostics is crucial to the success or failure of aptamer businesses or products. A well-conceived TPP will place the aptamer in an assay for a target against which antibodies are ill-suited or have difficulty detecting the analyte, such as some highly related proteins or poorly immunogenic small molecule haptens. Strong TPPs can also take advantage of the unique nucleic acid nature of aptamers, to produce assays with longer shelf life or special chemical properties and ability to be modified versus protein-based antibodies. The following chapter reviews the essence of well-conceived TPPs especially with respect to aptamer targets for diagnostics and illustrates several examples of commercial aptamer diagnostic success.

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Author information

Author notes

  1. Harleen Kaur and Bandhan Chaterjee contributed equally to this work.

Authors and Affiliations

  1. Aurobindo Biologics, Hyderabad, India

    Harleen Kaur

  2. Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India

    Bandhan Chaterjee & Tarun Kumar Sharma

  3. Nanohmics Inc., Austin, TX, USA

    John G. Bruno

Authors
  1. Harleen Kaur
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  2. Bandhan Chaterjee
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  3. John G. Bruno
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  4. Tarun Kumar Sharma
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Corresponding author

Correspondence to Tarun Kumar Sharma .

Editor information

Editors and Affiliations

  1. Basel, Switzerland

    Katharina Urmann

  2. University Hannover, Gottfried-Wilhelm Leibniz, Hannover, Niedersachsen, Germany

    Johanna-Gabriela Walter

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Kaur, H., Chaterjee, B., Bruno, J.G., Sharma, T.K. (2019). Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics. In: Urmann, K., Walter, JG. (eds) Aptamers in Biotechnology. Advances in Biochemical Engineering/Biotechnology, vol 174. Springer, Cham. https://doi.org/10.1007/10_2019_104

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