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Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer

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Genome Instability in Cancer Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 570))

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References

  • Al-Romaih, K., J. Bayani, J. Vorobyova, J. Karaskova, P.C. Park, M. Zielenska, and J.A. Squire. 2003. Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. Cancer Genetics and Cytogenetics. 144:91–99.

    Article  CAS  PubMed  Google Scholar 

  • Andersen, J.S., C.J. Wilkinson, T. Mayor, P. Mortensen, E.A. Nigg, and M. Mann. 2003. Proteomic characterization of the human centrosome by protein correlation profiling. Nature. 426:570–4.

    Article  CAS  PubMed  Google Scholar 

  • Ando, K., T. Ozaki, H. Yamamoto, K. Furuya, M. Hosoda, S. Hayashi, M. Fukuzawa, and A. Nakagawara. 2004. Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J Biol Chem. 279:25549–61.

    CAS  PubMed  Google Scholar 

  • Angus, S.P., A.F. Fribourg, M.P. Markey, S.L. Williams, H.F. Horn, J. DeGregori, T.F. Kowalik, K. Fukasawa, and E.S. Knudsen. 2002. Active RB elicits late G1/S inhibition. Exp Cell Res. 276:201–13.

    Article  CAS  PubMed  Google Scholar 

  • Aumais, J.P., S.N. Williams, W. Luo, M. Nishino, K.A. Caldwell, G.A. Caldwell, S.H. Lin, and L.Y. Yu-Lee. 2003. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci. 116:1991–2003.

    Article  CAS  PubMed  Google Scholar 

  • Avidor-Reiss, T., A.M. Maer, E. Koundakjian, A. Polyanovsky, T. Keil, S. Subramaniam, and C.S. Zuker. 2004. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell. 117:527–39.

    Article  CAS  PubMed  Google Scholar 

  • Bailly, E., J. Pines, T. Hunter, and M. Bornens. 1992. Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J Cell Sci. 101:529–45.

    CAS  PubMed  Google Scholar 

  • Balczon, R., L. Bao, W.E. Zimmer, K. Brown, R.P. Zinkowski, and B.R. Brinkley. 1995. Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells. J Cell Biol. 130:105–15.

    Article  CAS  PubMed  Google Scholar 

  • Balczon, R.C. 2001. Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction. Chromosoma. 110:381–92.

    Article  CAS  PubMed  Google Scholar 

  • Barr, F.A., H.H. Sillje, and E.A. Nigg. 2004. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol. 5:429–40.

    Article  CAS  PubMed  Google Scholar 

  • Bobinnec, Y., A. Khodjakov, L.M. Mir, C.L. Rieder, B. Edde, and M. Bornens. 1998. Centriole Disassembly In Vivo and Its Effect on Centrosome Structure and Function in Vertebrate Cells. J. Cell Biol. 143:1575–1589.

    Article  CAS  PubMed  Google Scholar 

  • Boveri, T. 1914. Zur Frage der Entstehung Maligner Tumoren. Jena: Fischer Verlag (1929 English translation by M. Boveri reprinted as The Origin of malignant tumours, The Williams and Wilkins Co., Baltimore), Baltimore. 119 pp.

    Google Scholar 

  • Brinkley, B.R. 2001. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol. 11:18–21.

    Article  CAS  PubMed  Google Scholar 

  • Carroll, P.E., M. Okuda, H.F. Horn, P. Biddinger, P.J. Stambrook, L.L. Gleich, Y.Q. Li, P. Tarapore, and K. Fukasawa. 1999. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene. 18:1935–44.

    Article  CAS  PubMed  Google Scholar 

  • Casenghi, M., P. Meraldi, U. Weinhart, P.I. Duncan, R. Korner, and E.A. Nigg. 2003. Pololike kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell. 5:113–25.

    Article  CAS  PubMed  Google Scholar 

  • Castedo, M., J.L. Perfettini, T. Roumier, K. Andreau, R. Medema, and G. Kroemer. 2004a. Cell death by mitotic catastrophe: a molecular definition. Oncogene. 23:2825–37.

    CAS  PubMed  Google Scholar 

  • Castedo, M., J.L. Perfettini, T. Roumier, A. Valent, H. Raslova, K. Yakushijin, D. Horne, J. Feunteun, G. Lenoir, R. Medema, W. Vainchenker, and G. Kroemer. 2004b. Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene. 23:4362–70.

    CAS  PubMed  Google Scholar 

  • Cha, H., C. Hancock, S. Dangi, D. Maiguel, F. Carrier, and P. Shapiro. 2004. Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by crossreactive phosphorylation-specific MKK1/MKK2 antibodies. Biochem J. 378:857–65.

    Article  CAS  PubMed  Google Scholar 

  • Chen, C.H., S.L. Howng, T.S. Cheng, M.H. Chou, C.Y. Huang, and Y.R. Hong. 2003. Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle. Biochem Biophys Res Commun. 308:975–83.

    CAS  PubMed  Google Scholar 

  • Chen, Y., D.J. Riley, L. Zheng, P.L. Chen, and W.H. Lee. 2002a. Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. J Biol Chem. 277:49408–16.

    CAS  PubMed  Google Scholar 

  • Chen, Z., V.B. Indjeian, M. McManus, L. Wang, and B.D. Dynlacht. 2002b. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 3:339–50.

    Article  CAS  PubMed  Google Scholar 

  • Crosio, C., G.M. Fimia, R. Loury, M. Kimura, Y. Okano, H. Zhou, S. Sen, C.D. Allis, and P. Sassone-Corsi. 2002. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol. 22:874–85.

    Article  CAS  PubMed  Google Scholar 

  • D’Assoro, A.B., R. Busby, K. Suino, E. Delva, G.J. Almodovar-Mercado, H. Johnson, C. Folk, D.J. Farrugia, V. Vasile, F. Stivala, and J.L. Salisbury. 2004. Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint. Oncogene. 23:4068–4075.

    CAS  PubMed  Google Scholar 

  • D’Assoro, A.B., W.L. Lingle, and J.L. Salisbury. 2002. Centrosome amplification and the development of cancer. Oncogene. 21:6146–53.

    CAS  PubMed  Google Scholar 

  • Dai, W., and J.P. Cogswell. 2003. Polo-like kinases and the microtubule organization center: targets for cancer therapies. Prog Cell Cycle Res. 5:327–34.

    PubMed  Google Scholar 

  • Dai, W., Q. Wang, and F. Traganos. 2002. Polo-like kinases and centrosome regulation. Oncogene. 21:6195–200.

    Article  CAS  PubMed  Google Scholar 

  • De Camilli, P., M. Moretti, S.D. Donini, U. Walter, and S.M. Lohmann. 1986. Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex. J Cell Biol. 103:189–203.

    PubMed  Google Scholar 

  • Debec, A., and C. Montmory. 1992. Cyclin B is associated with centrosomes in Drosophila mitotic cells. Biol Cell. 75:121–6.

    Article  CAS  PubMed  Google Scholar 

  • Deng, C.X., and S.G. Brodie. 2000. Roles of BRCA1 and its interacting proteins. Bioessays. 22:728–37.

    Article  CAS  PubMed  Google Scholar 

  • Diviani, D., L.K. Langeberg, S.J. Doxsey, and J.D. Scott. 2000. Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Curr Biol. 10:417–20.

    Article  CAS  PubMed  Google Scholar 

  • Diviani, D., and J.D. Scott. 2001. AKAP signalling complexes at the cytoskeleton. J Cell Sci. 114:1431–7.

    CAS  PubMed  Google Scholar 

  • Dodson, H., E. Bourke, L.J. Jeffers, P. Vagnarelli, E. Sonoda, S. Takeda, W.C. Earnshaw, A. Merdes, and C. Morrison. 2004. Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J.

    Google Scholar 

  • Doxsey, S. 2001a. Re-evaluating centrosome function. Nat Rev Mol Cell Biol. 2:688–98.

    Article  CAS  PubMed  Google Scholar 

  • Doxsey, S.J. 2001b. Centrosomes as command centres for cellular control. Nat Cell Biol. 3:E105–8.

    Article  CAS  PubMed  Google Scholar 

  • Du, J., and G.J. Hannon. 2002. The centrosomal kinase Aurora-A/STK15 interacts with a putative tumour suppressor NM23-H1. Nucleic Acids Res. 30:5465–75.

    Article  CAS  PubMed  Google Scholar 

  • Du, J., and G.J. Hannon. 2004. Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. PNAS. 101:8975–8980.

    CAS  PubMed  Google Scholar 

  • Duensing, S., L.Y. Lee, A. Duensing, J. Basile, S. Piboonniyom, S. Gonzalez, C.P. Crum, and K. Munger. 2000. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci U S A. 97:10002–7.

    Article  CAS  PubMed  Google Scholar 

  • Duensing, S., and K. Munger. 2002a. The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res. 62:7075–82.

    CAS  PubMed  Google Scholar 

  • Duensing, S., and K. Munger. 2002b. Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability. Oncogene. 21:6241–8.

    Article  CAS  PubMed  Google Scholar 

  • Dutertre, S., M. Cazales, M. Quaranta, C. Froment, V. Trabut, C. Dozier, G. Mirey, J.-P. Bouche, N. Theis-Febvre, E. Schmitt, B. Monsarrat, C. Prigent, and B. Ducommun. 2004. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci. 117:2523–2531.

    Article  CAS  PubMed  Google Scholar 

  • Dutertre, S., S. Descamps, and C. Prigent. 2002. On the role of aurora-A in centrosome function. Oncogene. 21:6175–83.

    Article  CAS  PubMed  Google Scholar 

  • Dutertre, S., and C. Prigent. 2003. Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint. Mol Interv. 3:127–30.

    Article  CAS  PubMed  Google Scholar 

  • el-, W.S., T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumour suppression. Cell. 75:817–25.

    Article  CAS  PubMed  Google Scholar 

  • Faragher, A.J., and A.M. Fry. 2003. Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. Mol Biol Cell. 14:2876–89.

    Article  CAS  PubMed  Google Scholar 

  • Fisk, H.A., C.P. Mattison, and M. Winey. 2003. Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. Proc Natl Acad Sci U S A. 100:14875–80.

    Article  CAS  PubMed  Google Scholar 

  • Fisk, H.A., and M. Winey. 2001. The mouse Mps1p-like kinase regulates centrosome duplication. Cell. 106:95–104.

    Article  CAS  PubMed  Google Scholar 

  • Fry, A.M. 2002. The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene. 21:6184–94.

    Article  CAS  PubMed  Google Scholar 

  • Fry, A.M., L. Arnaud, and E.A. Nigg. 1999. Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif. J Biol Chem. 274:16304–10.

    CAS  PubMed  Google Scholar 

  • Fry, A.M., T. Mayor, P. Meraldi, Y.D. Stierhof, K. Tanaka, and E.A. Nigg. 1998a. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol. 141:1563–74.

    Article  CAS  PubMed  Google Scholar 

  • Fry, A.M., T. Mayor, and E.A. Nigg. 2000. Regulating centrosomes by protein phosphorylation. In Centrosome in Cell Replication and Early Development. Vol. 49. 291–312.

    CAS  Google Scholar 

  • Fry, A.M., P. Meraldi, and E.A. Nigg. 1998b. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 17:470–81.

    Article  CAS  PubMed  Google Scholar 

  • Fry, A.M., S.J. Schultz, J. Bartek, and E.A. Nigg. 1995. Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J Biol Chem. 270:12899–905.

    CAS  PubMed  Google Scholar 

  • Fukasawa, K., T. Choi, R. Kuriyama, S. Rulong, and G.F. Vande Woude. 1996. Abnormal centrosome amplification in the absence of p53. Science. 271:1744–7.

    CAS  PubMed  Google Scholar 

  • Giannakakou, P., D.L. Sackett, Y. Ward, K.R. Webster, M.V. Blagosklonny, and T. Fojo. 2000. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat Cell Biol. 2:709–717.

    Article  CAS  PubMed  Google Scholar 

  • Giet, R., R. Uzbekov, I. Kireev, and C. Prigent. 1999. The Xenopus laevis centrosome aurora/Ipl1-related kinase. Biol Cell. 91:461–70.

    Article  CAS  PubMed  Google Scholar 

  • Gillingham, A.K., and S. Munro. 2000. The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin. Embo Reports. 1:524–529.

    CAS  PubMed  Google Scholar 

  • Gisselsson, D. 2003. Chromosome instability in cancer: How, when, and why? Advances in Cancer Research, Vol 87. 87:1–29.

    CAS  Google Scholar 

  • Gisselsson, D., L. Gorunova, M. Hoglund, N. Mandahl, and P. Elfving. 2004. Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas. Br J Cancer. 91:327–32.

    CAS  PubMed  Google Scholar 

  • Goepfert, T.M., and B.R. Brinkley. 2000. The centrosome-associated Aurora/Ipl-like kinase family. Curr Top Dev Biol. 49:331–42.

    CAS  PubMed  Google Scholar 

  • Goepfert, T.M., M. McCarthy, F.S. Kittrell, C. Stephens, R.L. Ullrich, B.R. Brinkley, and D. Medina. 2000. Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells. Faseb Journal. 14:2221–2229.

    Article  CAS  PubMed  Google Scholar 

  • Golan, A., Y. Yudkovsky, and A. Hershko. 2002. The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem. 277:15552–7.

    Article  CAS  PubMed  Google Scholar 

  • Golsteyn, R.M., K.E. Mundt, A.M. Fry, and E.A. Nigg. 1995. Cell cycle regulation of the activity and subcellular localization of PLK1, a human protein kinase implicated in mitotic spindle function. J. Cell Biol. 129:1617–1628.

    Article  CAS  PubMed  Google Scholar 

  • Golsteyn, R.M., S.J. Schultz, J. Bartek, A. Ziemiecki, T. Ried, and E.A. Nigg. 1994. Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J Cell Sci. 107 ( Pt 6):1509–17.

    CAS  PubMed  Google Scholar 

  • Grigorova, M., J.M. Staines, H. Ozdag, C. Caldas, and P.A. Edwards. 2004. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet Genome Res. 104:333–40.

    Article  CAS  PubMed  Google Scholar 

  • Grimm, D. 2004. Genetics. Disease backs cancer origin theory. Science. 306:389.

    Article  CAS  PubMed  Google Scholar 

  • Hamill, D.R., A.F. Severson, J.C. Carter, and B. Bowerman. 2002. Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains. Dev Cell. 3:673–84.

    Article  CAS  PubMed  Google Scholar 

  • Hanks, S., K. Coleman, S. Reid, A. Plaja, H. Firth, D. Fitzpatrick, A. Kidd, K. Mehes, R. Nash, N. Robin, N. Shannon, J. Tolmie, J. Swansbury, A. Irrthum, J. Douglas, and N. Rahman. 2004. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet. 36:1159–61.

    Article  CAS  PubMed  Google Scholar 

  • Hashizume, R., M. Fukuda, I. Maeda, H. Nishikawa, D. Oyake, Y. Yabuki, H. Ogata, and T. Ohta. 2001. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem. 276:14537–40.

    Article  CAS  PubMed  Google Scholar 

  • Hayward, D.G., R.B. Clarke, A.J. Faragher, M.R. Pillai, I.M. Hagan, and A.M. Fry. 2004. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res. 64:7370–6.

    Article  CAS  PubMed  Google Scholar 

  • Helps, N.R., X. Luo, H.M. Barker, and P.T. Cohen. 2000. NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem J. 349:509–18.

    Article  CAS  PubMed  Google Scholar 

  • Hernando, E., Z. Nahle, G. Juan, E. Diaz-Rodriguez, M. Alaminos, M. Hemann, L. Michel, V. Mittal, W. Gerald, R. Benezra, S.W. Lowe, and C. Cordon-Cardo. 2004. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 430:797–802.

    Article  CAS  PubMed  Google Scholar 

  • Hinchcliffe, E.H., C. Li, E.A. Thompson, J.L. Maller, and G. Sluder. 1999. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts [see comments]. Science. 283:851–4.

    Article  CAS  PubMed  Google Scholar 

  • Hinchcliffe, E.H., F.J. Miller, M. Cham, A. Khodjakov, and G. Sluder. 2001. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science. 291:1547–50.

    Article  CAS  PubMed  Google Scholar 

  • Hirota, T., N. Kunitoku, T. Sasayama, T. Marumoto, D. Zhang, M. Nitta, K. Hatakeyama, and H. Saya. 2003. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 114:585–98.

    Article  CAS  PubMed  Google Scholar 

  • Hoque, A., J. Carter, W. Xia, M.-C. Hung, A.A. Sahin, S. Sen, and S.M. Lippman. 2003. Loss of Aurora A/STK15/BTAK Overexpression Correlates with Transition of in Situ to Invasive Ductal Carcinoma of the Breast. Cancer Epidemiol Biomarkers Prev. 12:1518–1522.

    CAS  PubMed  Google Scholar 

  • Hsu, L.C., and R.L. White. 1998. BRCA1 is associated with the centrosome during mitosis. Proc Natl Acad Sci U S A. 95:12983–8.

    Article  CAS  PubMed  Google Scholar 

  • Huang, A.M., C. Montagna, S. Sharan, Y. Ni, T. Ried, and E. Sterneck. 2004. Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability. Oncogene. 23:1549–57.

    CAS  PubMed  Google Scholar 

  • Hut, H.M., W. Lemstra, E.H. Blaauw, G.W. Van Cappellen, H.H. Kampinga, and O.C. Sibon. 2003. Centrosomes Split in the Presence of Impaired DNA Integrity during Mitosis. Mol Biol Cell. 14:1993–2004.

    Article  CAS  PubMed  Google Scholar 

  • Jackman, M., C. Lindon, E.A. Nigg, and J. Pines. 2003. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol. 5:143–8.

    Article  CAS  PubMed  Google Scholar 

  • Jiang, F., N.P. Caraway, A.L. Sabichi, H.Z. Zhang, A. Ruitrok, H.B. Grossman, J. Gu, S.P. Lerner, S. Lippman, and R.L. Katz. 2003. Centrosomal abnormality is common in and a potential biomarker for bladder cancer. International Journal of Cancer. 106:661–665.

    CAS  Google Scholar 

  • Katayama, H., W.R. Brinkley, and S. Sen. 2003. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 22:451–64.

    Article  PubMed  Google Scholar 

  • Katayama, H., K. Sasai, H. Kawai, Z.M. Yuan, J. Bondaruk, F. Suzuki, S. Fujii, R.B. Arlinghaus, B.A. Czerniak, and S. Sen. 2004. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 36:55–62.

    Article  CAS  PubMed  Google Scholar 

  • Kawamura, K., H. Izumi, Z. Ma, R. Ikeda, M. Moriyama, T. Tanaka, T. Nojima, L.S. Levin, K. Fujikawa-Yamamoto, K. Suzuki, and K. Fukasawa. 2004. Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression. Cancer Res. 64:4800–9.

    Article  CAS  PubMed  Google Scholar 

  • Kawamura, K., M. Moriyama, N. Shiba, M. Ozaki, T. Tanaka, T. Nojima, K. Fujikawa-Yamamoto, R. Ikeda, and K. Suzuki. 2003. Centrosome Hyperamplification and Chromosomal Instability in Bladder Cancer. European Urology. 43:505–515.

    Article  CAS  PubMed  Google Scholar 

  • Kearns, W.G., J.F. Sutton, J.P. Maciejewski, N.S. Young, and J.M. Liu. 2004. Genomic instability in bone marrow failure syndromes. Am J Hematol. 76:220–4.

    Article  PubMed  Google Scholar 

  • Keezer, S.M., and D.M. Gilbert. 2002. Sensitivity of the origin decision point to specific inhibitors of cellular signalling and metabolism. Exp Cell Res. 273:54–64.

    Article  CAS  PubMed  Google Scholar 

  • Keryer, G., R.M. Rios, B.F. Landmark, B. Skalhegg, S.M. Lohmann, and M. Bornens. 1993. A high-affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II in the centrosome of human cells. Exp Cell Res. 204:230–40.

    Article  CAS  PubMed  Google Scholar 

  • Keryer, G., B.S. Skalhegg, B.F. Landmark, V. Hansson, T. Jahnsen, and K. Tasken. 1999. Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area. Exp Cell Res. 249:131–46.

    Article  CAS  PubMed  Google Scholar 

  • Keryer, G., O. Witczak, A. Delouvee, W.A. Kemmner, D. Rouillard, K. Tasken, and M. Bornens. 2003. Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression. Mol. Biol. Cell. 14:2436–2446.

    CAS  PubMed  Google Scholar 

  • Khodjakov, A., and C.L. Rieder. 1999. The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. J Cell Biol. 146:585–96.

    Article  CAS  PubMed  Google Scholar 

  • Khodjakov, A., and C.L. Rieder. 2001. Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J Cell Biol. 153:237–42.

    Article  CAS  PubMed  Google Scholar 

  • Kraft, C., F. Herzog, C. Gieffers, K. Mechtler, A. Hagting, J. Pines, and J.M. Peters. 2003. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J. 22:6598–6609.

    Article  CAS  PubMed  Google Scholar 

  • Kramer, A., K. Neben, and A.D. Ho. 2002. Centrosome replication, genomic instability and cancer. Leukemia. 16:767–75.

    CAS  PubMed  Google Scholar 

  • Kramer, A., S. Schweizer, K. Neben, C. Giesecke, J. Kalla, T. Katzenberger, A. Benner, H.K. Muller-Hermelink, A.D. Ho, and G. Ott. 2003. Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin’s lymphoma. Leukemia. 17:2207–13.

    CAS  PubMed  Google Scholar 

  • Kronenwett, U., J. Castro, U.J. Roblick, K. Fujioka, C. Ostring, F. Faridmoghaddam, N. Laytragoon-Lewin, B. Tribukait, and G. Auer. 2003. Expression of Cyclins A, E and Topoisomerase II alpha correlates with centrosome amplification and genomic instability and influences the reliability of cytometric S-phase determination. BMC Cell Biol. 4:8.

    Article  PubMed  Google Scholar 

  • Kronenwett, U., S. Huwendiek, C. Ostring, N. Portwood, U.J. Roblick, Y. Pawitan, A. Alaiya, R. Sennerstam, A. Zetterberg, and G. Auer. 2004. Improved Grading of Breast Adenocarcinomas Based on Genomic Instability. Cancer Res. 64:904–909.

    Article  CAS  PubMed  Google Scholar 

  • Kufer, T.A., H.H.W. Sillje, R. Korner, O.J. Gruss, P. Meraldi, and E.A. Nigg. 2002. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J. Cell Biol. 158:617–623.

    Article  CAS  PubMed  Google Scholar 

  • Kunitoku, N., T. Sasayama, T. Marumoto, D. Zhang, S. Honda, O. Kobayashi, K. Hatakeyama, Y. Ushio, H. Saya, and T. Hirota. 2003. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell. 5:853–64.

    Article  CAS  PubMed  Google Scholar 

  • Kuriyama, R., and G.G. Borisy. 1981. Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle. J Cell Biol. 91:822–6.

    CAS  PubMed  Google Scholar 

  • Lacey, K.R., P.K. Jackson, and T. Stearns. 1999. Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci U S A. 96:2817–2822.

    Article  CAS  PubMed  Google Scholar 

  • Lane, H.A., and E.A. Nigg. 1996. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J Cell Biol. 135:1701–13.

    Article  CAS  PubMed  Google Scholar 

  • Lauze, E., B. Stoelcker, F.C. Luca, E. Weiss, A.R. Schutz, and M. Winey. 1995. Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. EMBO J. 14:1655–63.

    CAS  PubMed  Google Scholar 

  • Lee, M., M.J. Daniels, and A.R. Venkitaraman. 2004. Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 23:865–72.

    CAS  PubMed  Google Scholar 

  • Lengauer, C., K. Kinzler, and B. Vogelstein. 1997. Genetic instability in colorectal cancers. Nature. 386:623–627.

    Article  CAS  PubMed  Google Scholar 

  • Li, J.B., J.M. Gerdes, C.J. Haycraft, Y. Fan, T.M. Teslovich, H. May-Simera, H. Li, O.E. Blacque, L. Li, C.C. Leitch, R.A. Lewis, J.S. Green, P.S. Parfrey, M.R. Leroux, W.S. Davidson, P.L. Beales, L.M. Guay-Woodford, B.K. Yoder, G.D. Stormo, N. Katsanis, and S.K. Dutcher. 2004. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell. 117:541–52.

    Article  CAS  PubMed  Google Scholar 

  • Li, J.J., J.S. Weroha, L.L. Lingle, D. Papa, J.L. Salisbury, and S.A. Li. 2005. Estrogen mediates Aurora-A over-expression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats. Proc Natl Acad Sci U S A. (in press).

    Google Scholar 

  • Liby, K., H. Wu, B. Ouyang, S. Wu, J. Chen, and W. Dai. 2001. Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. DNA Seq. 11:527–33.

    CAS  PubMed  Google Scholar 

  • Lin, H.R., N.S. Ting, J. Qin, and W.H. Lee. 2003. M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex. J Biol Chem. 278:35979–87.

    CAS  PubMed  Google Scholar 

  • Lingle, W.L., S.L. Barrett, V.C. Negron, A.B. D’Assoro, K. Boeneman, W. Liu, C.M. Whitehead, C. Reynolds, and J.L. Salisbury. 2002. Centrosome amplification drives chromosomal instability in breast tumour development. Proc Natl Acad Sci U S A. 99:1978–1983.

    Article  CAS  PubMed  Google Scholar 

  • Lingle, W.L., W.H. Lutz, J.N. Ingle, N.J. Maihle, and J.L. Salisbury. 1998. Centrosome hypertrophy in human breast tumours: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A. 95:2950–5.

    Article  CAS  PubMed  Google Scholar 

  • Lingle, W.L., and J.L. Salisbury. 1999. Altered centrosome structure is associated with abnormal mitoses in human breast tumours. Am J Pathol. 155:1941–51.

    CAS  PubMed  Google Scholar 

  • Logarinho, E., and C.E. Sunkel. 1998. The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes. J Cell Sci. 111:2897–909.

    CAS  PubMed  Google Scholar 

  • Lou, Y., W. Xie, D.F. Zhang, J.H. Yao, Z.F. Luo, Y.Z. Wang, Y.Y. Shi, and X.B. Yao. 2004. Nek2A specifies the centrosomal localization of Erk2. Biochem Biophys Res Commun. 321:495–501.

    Article  CAS  PubMed  Google Scholar 

  • Lutz, W., W.L. Lingle, D. McCormick, T.M. Greenwood, and J.L. Salisbury. 2001. Phosphorylation of Centrin during the Cell Cycle and Its Role in Centriole Separation Preceding Centrosome Duplication. J. Biol. Chem. 276:20774–20780.

    Article  CAS  PubMed  Google Scholar 

  • Ma, S., J. Charron, and R.L. Erikson. 2003. Role of Plk2 (Snk) in mouse development and cell proliferation. Mol Cell Biol. 23:6936–43.

    CAS  PubMed  Google Scholar 

  • Massimi, P., D. Pim, C. Kuhne, and L. Banks. 2001. Regulation of the human papillomavirus oncoproteins by differential phosphorylation. Mol Cell Biochem. 227:137–44.

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto, Y., K. Hayashi, and E. Nishida. 1999. Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr Biol. 9:429–32.

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto, Y., and J.L. Maller. 2004. A centrosomal localization signal in cyclin E required for Cdk-2independent S phase entry. Science. 306:885–888.

    Article  CAS  PubMed  Google Scholar 

  • Matyakhina, L., S.M. Lenherr, and C.A. Stratakis. 2002. Protein kinase A and chromosomal stability. Ann N Y Acad Sci. 968:148–57.

    Article  CAS  PubMed  Google Scholar 

  • Mayer, F., H. Stoop, S. Sen, C. Bokemeyer, J.W. Oosterhuis, and L.H. Looijenga. 2003. Aneuploidy of human testicular germ cell tumours is associated with amplification of centrosomes. Oncogene. 22:3859–66.

    Article  CAS  PubMed  Google Scholar 

  • Meraldi, P., R. Honda, and E.A. Nigg. 2002. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/-cells. EMBO J. 21:483–492.

    Article  CAS  PubMed  Google Scholar 

  • Meraldi, P., R. Honda, and E.A. Nigg. 2004. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev. 14:29–36.

    Article  CAS  PubMed  Google Scholar 

  • Meraldi, P., J. Lukas, A. Fry, J. Bartek, and E. Nigg. 1999. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nature Cell Biol. 1:88–93.

    CAS  PubMed  Google Scholar 

  • Meraldi, P., and E.A. Nigg. 2001. Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J Cell Sci. 114:3749–3757.

    CAS  PubMed  Google Scholar 

  • Metcalf, M.M. 1925. Boveri’s work on cancer. JAMA. 84:1140.

    Google Scholar 

  • Mills, G.B., R. Schmandt, M. McGill, A. Amendola, M. Hill, K. Jacobs, C. May, A.M. Rodricks, S. Campbell, and D. Hogg. 1992. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. J Biol Chem. 267:16000–6.

    CAS  PubMed  Google Scholar 

  • Morrison, C., and C.L. Rieder. 2004. Chromosome damage and progression into and through mitosis in vertebrates. DNA Repair. 3:1133–1139.

    Article  CAS  PubMed  Google Scholar 

  • Moudjou, M., N. Bordes, M. Paintrand, and M. Bornens. 1996. gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms. J Cell Sci. 109:875–87.

    CAS  PubMed  Google Scholar 

  • Murphy, K.L., A.P. Dennis, and J.M. Rosen. 2000. A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model. Faseb J. 14:2291–302.

    Article  CAS  PubMed  Google Scholar 

  • Nakajima, H., F. Toyoshima-Morimoto, E. Taniguchi, and E. Nishida. 2003. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J Biol Chem. 278:25277–80.

    Article  CAS  PubMed  Google Scholar 

  • Nakajima, T., M. Moriguchi, Y. Mitsumoto, S. Sekoguchi, T. Nishikawa, H. Takashima, T. Watanabe, T. Katagishi, H. Kimura, T. Okanoue, and K. Kagawa. 2004. Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma. Mod Pathol. 17:722–7.

    Article  CAS  PubMed  Google Scholar 

  • Neben K., B. Tews, G. Wrobel, M. Hahn, F. Kokocinski, C. Giesecke, U. Krause, A.D. Ho, A. Kramer, P. Lichter. 2004. Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changes. [Article] Oncogene. 23:2379–2384.

    Article  CAS  PubMed  Google Scholar 

  • Neef, R., C. Preisinger, J. Sutcliffe, R. Kopajtich, E.A. Nigg, T.U. Mayer, and F.A. Barr. 2003. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol. 162:863–75.

    Article  CAS  PubMed  Google Scholar 

  • Nelsen, C.J., R. Kuriyama, B. Hirsch, V.C. Negron, W.L. Lingle, M.M. Goggin, M.W. Stanley, and J.H. Albrecht. 2004. Short-term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy. J Biol Chem.

    Google Scholar 

  • Nigg, E., G. Schäfer, H. Hilz, and H. Eppenberger. 1985. Cyclic-AMP-dependent protein kinase type II is associated with Golgi complex and with centrosomes. Cell. 41:1039–1051.

    Article  CAS  PubMed  Google Scholar 

  • Nigg, E.A. 2001. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol. 2:21–32.

    Article  CAS  PubMed  Google Scholar 

  • Nigg, E.A. 2002. Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer. 2:815–25.

    Article  CAS  PubMed  Google Scholar 

  • Nigg, E.A. (Editor) 2004. Centrosomes in Development and Disease. Wiley-VCH, Weinheim, Germany.

    Google Scholar 

  • Noguchi, K., H. Fukazawa, Y. Murakami, and Y. Uehara. 2004. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. J Biol Chem. 279:32716–27.

    CAS  PubMed  Google Scholar 

  • O’Connell, M.J., M.J. Krien, and T. Hunter. 2003. Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol. 13:221–8.

    CAS  PubMed  Google Scholar 

  • Ochi, T., T. Suzuki, J.C. Barrett, and T. Tsutsui. 2004. A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells. Toxicology. 203:155–163.

    Article  CAS  PubMed  Google Scholar 

  • Okuda, M. 2002. The role of nucleophosmin in centrosome duplication. Oncogene. 21:6170–4.

    Article  CAS  PubMed  Google Scholar 

  • Okuda, M., H.F. Horn, P. Tarapore, Y. Tokuyama, A.G. Smulian, P.K. Chan, E.S. Knudsen, I.A. Hofmann, J.D. Snyder, K.E. Bove, and K. Fukasawa. 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell. 103:127–40.

    Article  CAS  PubMed  Google Scholar 

  • Ou, Y., M. Zhang, and J.B. Rattner. 2004. The centrosome: The centriole-PCM coalition. Cell Motil Cytoskeleton. 57:1–7.

    Article  CAS  PubMed  Google Scholar 

  • Ouchi, M., N. Fujiuchi, K. Sasai, H. Katayama, Y.A. Minamishima, P.P. Ongusaha, C. Deng, S. Sen, S.W. Lee, and T. Ouchi. 2004. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 279:19643–8.

    Article  CAS  PubMed  Google Scholar 

  • Pan, H., F. Zhou, and S.J. Gao. 2004. Kaposi’s sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells. Cancer Res. 64:4064–8.

    Article  CAS  PubMed  Google Scholar 

  • Pazour, G.J., B.L. Dickert, Y. Vucica, E.S. Seeley, J.L. Rosenbaum, G.B. Witman, and D.G. Cole. 2000. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 151:709–18.

    Article  CAS  PubMed  Google Scholar 

  • Perucca-Lostanlen, D., P. Rostagno, J. Grosgeorge, S. Marcie, P. Gaudray, and C. Turc-Carel. 2004. Distinct MDM2 and P14ARF expression and centrosome amplification in welldifferentiated liposarcomas. Genes Chromosomes Cancer. 39:99–109.

    Article  CAS  PubMed  Google Scholar 

  • Piel, M., P. Meyer, A. Khodjakov, C.L. Rieder, and M. Bornens. 2000. The respective contributions of the mother and daughter centrioles to centrosome activity and behaviour in vertebrate cells. J Cell Biol. 149:317–30.

    Article  CAS  PubMed  Google Scholar 

  • Piel, M., J. Nordberg, U. Euteneuer, and M. Bornens. 2001. Centrosome-dependent exit of cytokinesis in animal cells. Science. 291:1550–3.

    Article  CAS  PubMed  Google Scholar 

  • Pihan, G.A., A. Purohit, J. Wallace, H. Knecht, B. Woda, P. Quesenberry, and S.J. Doxsey. 1998. Centrosome defects and genetic instability in malignant tumours. Cancer Res. 58:3974–85.

    CAS  PubMed  Google Scholar 

  • Pihan, G.A., A. Purohit, J. Wallace, R. Malhotra, L. Liotta, and S.J. Doxsey. 2001. Centrosome Defects Can Account for Cellular and Genetic Changes That Characterize Prostate Cancer Progression. Cancer Res. 61:2212–2219.

    CAS  PubMed  Google Scholar 

  • Pihan, G.A., J. Wallace, Y. Zhou, and S.J. Doxsey. 2003. Centrosome Abnormalities and Chromosome Instability Occur Together in Pre-invasive Carcinomas. Cancer Res. 63:1398–404.

    CAS  PubMed  Google Scholar 

  • Pines, J. 1995. Cyclins, CDKs and cancer. Seminars in Cancer Biology. 6:63–72.

    Article  CAS  PubMed  Google Scholar 

  • Pockwinse, S.M., G. Krockmalnic, S.J. Doxsey, J. Nickerson, J.B. Lian, A.J. van Wijnen, J.L. Stein, G.S. Stein, and S. Penman. 1997. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc Natl Acad Sci U S A. 94:3022–7.

    Article  CAS  PubMed  Google Scholar 

  • Preble, A.M., T.M. Giddings, and S.K. Dutcher. 2000. Basal bodies and centrioles: Their function and structure. In Centrosome in Cell Replication and Early Development. Vol. 49. 207–233.

    CAS  Google Scholar 

  • Rao, P.N., J.Y. Zhao, R.K. Ganju, and C.L. Ashorn. 1989. Monoclonal antibody against the centrosome. J Cell Sci. 93:63–9.

    CAS  PubMed  Google Scholar 

  • Rattner, J.B., J. Lew, and J.H. Wang. 1990. p34cdc2 kinase is localized to distinct domains within the mitotic apparatus. Cell Motil Cytoskeleton. 17:227–35.

    Article  CAS  PubMed  Google Scholar 

  • Roh, M., B. Gary, C. Song, N. Said-Al-Naief, A. Tousson, A. Kraft, I.-E. Eltoum, and S.A. Abdulkadir. 2003. Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. Cancer Res. 63:8079–8084.

    CAS  PubMed  Google Scholar 

  • Rosenbaum, J.L., and G.B. Witman. 2002. Intraflagellar transport. Nat Rev Mol Cell Biol. 3:813–25.

    Article  CAS  PubMed  Google Scholar 

  • Saavedra, H.I., B. Maiti, C. Timmers, R. Altura, Y. Tokuyama, K. Fukasawa, and G. Leone. 2003. Inactivation of E2F3 results in centrosome amplification. Cancer Cell. 3:333–46.

    Article  CAS  PubMed  Google Scholar 

  • Salisbury, J.L. 2004. Centrosomes: sfi1p and centrin unravel a structural riddle. Curr Biol. 14:R27–9.

    CAS  PubMed  Google Scholar 

  • Salisbury, J.L., K.M. Suino, R. Busby, and M. Springett. 2002. Centrin-2 is required for centriole duplication in mammalian cells. Curr Biol. 12:1287–92.

    Article  CAS  PubMed  Google Scholar 

  • Sato, N., K. Mizumoto, M. Nakamura, N. Maehara, Y.A. Minamishima, S. Nishio, E. Nagai, and M. Tanaka. 2001. Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells. Cancer Genet Cytogenet. 126:13–9.

    Article  CAS  PubMed  Google Scholar 

  • Schiebel, E. 2000. gamma-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation. Curr Opin Cell Biol. 12:113–8.

    Article  CAS  PubMed  Google Scholar 

  • Schultz, S.J., A.M. Fry, C. Sutterlin, T. Ried, and E.A. Nigg. 1994. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth Differ. 5:625–35.

    CAS  PubMed  Google Scholar 

  • Sen, S. 2000. Aneuploidy and cancer. Curr Opin Oncology. 12:82–88.

    CAS  Google Scholar 

  • Sen, S., H. Zhou, and R.A. White. 1997. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene. 14:2195–200.

    Article  CAS  PubMed  Google Scholar 

  • Sluder, G., and E.H. Hinchcliffe. 1998. The apparent linkage between centriole replication and the S phase of the cell cycle. Cell Biol Int. 22:3–5.

    Article  CAS  PubMed  Google Scholar 

  • Sluder, G., and E.H. Hinchcliffe. 2000. The coordination of centrosome reproduction with nuclear events during the cell cycle. In Centrosome in Cell Replication and Early Development. Vol. 49. 267–289.

    CAS  Google Scholar 

  • Starita, L.M., Y. Machida, S. Sankaran, J.E. Elias, K. Griffin, B.P. Schlegel, S.P. Gygi, and J.D. Parvin. 2004. BRCA1-Dependent Ubiquitination of {gamma}-Tubulin Regulates Centrosome Number. Mol Cell Biol. 24:8457–8466.

    Article  CAS  PubMed  Google Scholar 

  • Stearns, T., L. Evans, and M. Kirschner. 1991. g-Tubulin is a highly conserved component of the centrosome. Cell. 65:825–836.

    Article  CAS  PubMed  Google Scholar 

  • Storchova, Z., and D. Pellman. 2004. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol. 5:45–54.

    Article  CAS  PubMed  Google Scholar 

  • Stucke, V.M., H.H. Sillje, L. Arnaud, and E.A. Nigg. 2002. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication EMBO J. 21:1723–32.

    Article  CAS  PubMed  Google Scholar 

  • Stucke, V.M., C. Baumann, and E.A. Nigg. 2004. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma. 113:1–15.

    Article  CAS  PubMed  Google Scholar 

  • Sunkel, C.E., and D.M. Glover. 1988. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci. 89:25–38.

    PubMed  Google Scholar 

  • Tarapore, P., M. Okuda, and K. Fukasawa. 2002. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell Cycle. 1:75–81.

    CAS  PubMed  Google Scholar 

  • Toji, S., N. Yabuta, T. Hosomi, S. Nishihara, T. Kobayashi, S. Suzuki, K. Tamai, and H. Nojima. 2004. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells. 9:383–97.

    Article  CAS  PubMed  Google Scholar 

  • Toyoshima-Morimoto, F., E. Taniguchi, and E. Nishida. 2002. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep. 3:341–8.

    Article  CAS  PubMed  Google Scholar 

  • Toyoshima-Morimoto, F., E. Taniguchi, N. Shinya, A. Iwamatsu, and E. Nishida. 2001. Pololike kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature. 410:215–20.

    Article  CAS  PubMed  Google Scholar 

  • Tsvetkov, L., X. Xu, J. Li, and D.F. Stern. 2003. Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody. J. Biol. Chem. 278:8468–8475.

    Article  CAS  PubMed  Google Scholar 

  • Tugendreich, S., J. Tomkiel, W. Earnshaw, and P. Hieter. 1995. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell. 81:261–8.

    Article  CAS  PubMed  Google Scholar 

  • Tutt, A., A. Gabriel, D. Bertwistle, F. Connor, H. Paterson, J. Peacock, G. Ross, and A. Ashworth. 1999. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr Biol. 9:1107–10.

    Article  CAS  PubMed  Google Scholar 

  • Vandre, D.D., Y. Feng, and M. Ding. 2000. Cell cycle-dependent phosphorylation of centrosomes: Localization of phosphopeptide specific antibodies to the centrosome. Microscopy Research and Technique. 49:458–466.

    CAS  PubMed  Google Scholar 

  • Verde, F., J.C. Labbe, M. Doree, and E. Karsenti. 1990. Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs. Nature. 343:233–8.

    Article  CAS  PubMed  Google Scholar 

  • Walter, A.O., W. Seghezzi, W. Korver, J. Sheung, and E. Lees. 2000. The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene. 19:4906–16.

    Article  CAS  PubMed  Google Scholar 

  • Wang, Q., Y. Hirohashi, K. Furuuchi, H.W. Zhao, Q.D. Liu, H.T. Zhang, R. Murali, A. Berezov, X.L. Du, B. Li, and M.I. Greene. 2004. The centrosome in normal and transformed cells. DNA and Cell Biology. 23:475–489.

    Article  CAS  PubMed  Google Scholar 

  • Wang, X.J., D.A. Greenhalgh, A. Jiang, D. He, L. Zhong, B.R. Brinkley, and D.R. Roop. 1998. Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function. Mol Carcinog. 23:185–92.

    Article  CAS  PubMed  Google Scholar 

  • Warnke, S., S. Kemmler, R.S. Hames, H.-L. Tsai, U. Hoffmann-Rohrer, A.M. Fry, and I. Hoffmann. 2004. Polo-like Kinase-2 Is Required for Centriole Duplication in Mammalian Cells. Current Biology. 14: 1200-1207.

    Google Scholar 

  • Weber, R.G., J.M. Bridger, A. Benner, D. Weisenberger, V. Ehemann, G. Reifenberger, and P. Lichter. 1998. Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumours with TP53 mutations. Cytogenet Cell Genet. 83:266–9.

    Article  CAS  PubMed  Google Scholar 

  • Wilson, E.B. 1925. The Cell in Development and Heredity. Macmillan Company, New York. 1232 pp.

    Google Scholar 

  • Winey, M., L. Goetsch, P. Baum, and B. Byers. 1991. MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. J Cell Biol. 114:745–54.

    Article  CAS  PubMed  Google Scholar 

  • Winey, M., and B.J. Huneycutt. 2002. Centrosomes and checkpoints: the MPS1 family of kinases. Oncogene. 21:6161–9.

    Article  CAS  PubMed  Google Scholar 

  • Witczak, O., B.S. Skalhegg, G. Keryer, M. Bornens, K. Tasken, T. Jahnsen, and S. Orstavik. 1999. Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J. 18:1858–68.

    Article  CAS  PubMed  Google Scholar 

  • Xu, X., Z. Weaver, S.P. Linke, C. Li, J. Gotay, X.W. Wang, C.C. Harris, T. Ried, and C.X. Deng. 1999. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 3:389–95.

    CAS  PubMed  Google Scholar 

  • Yanai, A., E. Arama, G. Kilfin, and B. Motro. 1997. ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis. Oncogene. 14:2943–50.

    Article  CAS  PubMed  Google Scholar 

  • Yarm, F.R. 2002. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. Mol Cell Biol. 22:6209–21.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, H., J. Kuang, L. Zhong, W.L. Kuo, J.W. Gray, A. Sahin, B.R. Brinkley, and S. Sen. 1998. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet. 20:189–93.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, T., J.P. Aumais, X. Liu, L.Y. Yu-Lee, and R.L. Erikson. 2003. A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 5:127–38.

    Article  CAS  PubMed  Google Scholar 

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Lingle, W.L., Lukasiewicz, K., Salisbury, J.L. (2005). Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer. In: Back, N., Cohen, I.R., Kritchevsky, D., Lajtha, A., Paoletti, R., Nigg, E.A. (eds) Genome Instability in Cancer Development. Advances in Experimental Medicine and Biology, vol 570. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3764-3_14

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