Genome Instability in Cancer Development

1. Front Matter

   Pages i-xv

   PDF

2. The Problem of Genome Instability

   1. The Multiplicity of Mutations in Human Cancers

      • Ranga N. Venkatesan, Lawrence A. Loeb

      Pages 3-17

   2. Monitoring Chromosome Rearrangements

      • Michael R. Speicher

      Pages 19-41

3. DNA Repair and Mutagenesis

   1. Nucleotide Excision Repair and its Connection with Cancer and Ageing

      • Jaan-Olle Andressoo, Jan H.J. Hoeijmakers, Harm de Waard

      Pages 45-83

   2. DNA Mismatch Repair and Colon Cancer

      • Giancarlo Marra, Josef Jiricny

      Pages 85-123

   3. Base Excision Repair

      • Lisiane B. Meira, Nicholas E. Burgis, Leona D. Samson

      Pages 125-173

   4. Genomic Instability in Cancer Development

      • Penny A. Jeggo

      Pages 175-197

   5. Translesion Synthesis And Errorprone Polymerases

      • Catherine M. Green, Alan R. Lehmann

      Pages 199-223

4. Cell Cycle Progression and Chromosome Aberration

   1. The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?

      • Ana del Gutierrez Arroyo, Gordon Peters

      Pages 227-247

   2. DNA Replication and Genomic Instability

      • Wenge Zhu, Tarek Abbas, Anindya Dutta

      Pages 249-279

   3. The Dream of Every Chromosome: Equal Segregation for a Healthy Life of the Host

      • Tomohiro Matsumoto, Mitsuhiro Yanagida

      Pages 281-310

   4. Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis

      • Roger A. Greenberg, K. Lenhard Rudolph

      Pages 311-341

   5. Gene Amplification Mechanisms

      • Michelle Debatisse, Bernard Malfoy

      Pages 343-361

   6. DNA Methylation and Cancer-associated Genetic Instability

      • Melanie Ehrlich

      Pages 363-392

   7. Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer

      • Wilma L. Lingle, Kara Lukasiewicz, Jeffrey L. Salisbury

      Pages 393-421

5. Genome Integrity Checkpoints

   1. Mammalian DNA Damage Response Pathway

      • Zhenkun Lou, Junjie Chen

      Pages 425-455

   2. ATM and Cellular Response to DNA Damage

      • Martin F. Lavin, Sergei Kozlov, Nuri Gueven, Cheng Peng, Geoff Birrell, Phillip Chen et al.

      Pages 457-476

   3. Mitotic Checkpoint, Aneuploidy and Cancer

      • Tim J. Yen, Gary D. Kao

      Pages 477-499

6. Back Matter

   Pages 501-511

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Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.

• Chromosom
• DNA
• Telomere
• aging
• dynamics
• genes

• State University of New York, Buffalo

  Nathan Back

• The Weizmann Institute of Science, Israel

  Irun R. Cohen

• Wistar Institute, USA

  David Kritchevsky

• N. S. Kline Institute for Psychiatric Research, USA

  Abel Lajtha

• University of Milan, Italy

  Rodolfo Paoletti

• Max-Planck Institute of Biochemistry, Martinsried, Germany

  Erich A. Nigg

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