Summary
Selenium is both an essential and a toxic trace element. It has been reported to induce cell growth and cell proliferation, but also cell death by necrosis or apoptosis. The biological action of selenium is dependent on both its specific chemical form and concentration. At high levels, selenium induces oxidation and cross-linking of protein thiol groups and generation of reactive oxygen species, ultimately leading to cell death. Indeed, a shift to a more oxidizing environment induced by selenium is thought to be largely responsible for selenium-induced apoptotic cell death. Selenium compounds capable of oxidizing thiol groups and generating the superoxide anion (O2 ●−) also trigger loss of the mitochondrial function and release of proapoptotic proteins, such as cytochrome c, from mitochondria into the cytosol. In addition, some selenium compounds activate caspase-3, which in turn contributes to morphological changes in the cell and DNA fragmentation characteristic of the late stage of apoptosis. The serial events of selenium-induced apoptosis are thus thought to include the generation of an oxidizing intracellular environment followed by induction of mitochondrial dysfunction, cytochrome c release, caspase-3 activation, and DNA fragmentation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
K Wada 1985 Metal and Human: ecotoxicology and clinical medicine Asakura Shoten Tokyo pp 134
JC King 2001 J Nutr 131:1355S
AC Wilson, HJ Thompson, PJ Schedin, NW Gibson, HE Ganther 1992 Biochem Pharmacol 43:1137
P Garberg, A Stahl, M Warholm, J Hogberg 1988 Biochem Pharmaco 137:3401
EM Ammar, D Couri 1981 Neurotoxicology 2:383
K E Panter, WJ Hartley, LF James, HF Mayland, BL Stegelmeier, PO Kechele 1996 Fundam Appl Toxico 132:217
JE Spallholz 1994 Free Radic Biol Med 17:45
U Tinggi 2003 Toxicol Lett 137:103
ML Penrith, 1995 J S Afr Vet Assoc 66:47
GQ Yang, SZ Wang, RH Zhou, SZ Sun 1983 Am J Clin Nutr 37:872
JE Spallholz 1997 Biomed Environ Sci 10:260
K Ge, G Yang 1993 Am J Clin Nutr 57:259S
I Rosenfeld, OB Beath 1964 Selenium. Genobotany. biochemistry, toxicity, and nutrition Academic Press, New York
TB Goehring, IS Palmer, OE Olson, GW Libal, RC Wahlstrom 1984 J Anim Sci 59:733
LD Koller, JH Exon 1986 Can J Vet Res 503:297
HD Stowe, AJ Eavey, L Granger, S Halstead, B Yamini 1992 J Am Vet Med Assoc 201:292
M Tsunoda, VJ Johnson, RP Sharma 2000 Arch Environ Contam Toxico 139:32
L Bjorkhem-Bergman, K Jonsson, LC Eriksson, JM Olsson, S Lehmann, C Paul, M Bjornstedt 2002 Biochem Pharmaco 163:1875
S Lopez, Y Miyashita, SSJr Simons 1990 J Biol Chem 265:16039
GD Frenkel, A Walcott, C Middleton 1987 Mol Pharmaco 131:112
MP Rayman 2000 Lancet 356:233
HM Shen, CF Yang, CN Ong 1999 Int J Cancer 81:820
L Yan, JE Spailholz 1993 Biochem Pharmaco 145:429
MS Stewart, JE Spallholz, KH Neldner, BC Pence 1999 Free Radic Biol Med 26:42
TS Kim, DW Jeong, BY Yun, IY Kim 2002 Biochem Biophys Res Commun 294:1130
TS Kim, BY Yun, IY Kim 2003 Biochem Pharmaco 166:2301
M Usami, H Tabata, Y Ohno 1999 Teratog Carcinog Mutagen 19:257
C Ip, HE Ganther 1990 Cancer Res 50:1206
ES Henle, S Linn 1997 J Biol Chem 272:19095
S Liu, D Shia, G Liu, H Chen, S Liu, Y Hu 2000 Life Sci 68:603
M Bjomstedt, S Kumar, A Holmgren 1992 J Biol Chem 267:8030
S Kumar, M Bjomstedt, A Holmgren 1992 Eur J Biochem 207:435
HJ Thompson, R Strange, PJ Schedin 1992 Cancer Epidemiol Biomarkers Prev 1:5972
HE Ganther 1999 Carcinogenesis 20:1657
JY Kim, HS Park, SI Kang, EJ Choi, IY Kim 2002 Biochim Biophys Acta 1569:67
J Ghosh 2004 Biochem Biophys Res Commun 315:624
PL Bergad, WB Rathbun 1986 Curr Eye Res 5:919
Y Tashima, M Terui, H Itoh, H Mizunuma, R Kobayashi, F Marumo 1989 J Biochem (Tokyo) 105:358
F Islam, Y Watanabe, H Morii, O Hayaishi 1991 Arch Biochem Biophys 289:161
R Sinha, D Medina 1997 Carcinogenesis 18:1541
R Gopalakrishna, ZH Chen, U Gundimeda 1997 Arch Biochem Biophys 348:37
ML Handel, CK Watts, A deFazio, RO Day, RL Sutherland 1995 Proc Natl Acad Sci U S A 92:4497
IY Kim, TC Stadtman 1997 Proc Natl Acad Sci U S A 94:12904
HS Park, SH Huh, Y Kim, J Shim, SH Lee, IS Park, YK Jung, IY Kim, EJ Choi 2000 J Biol Chem 275:8487
HS Park, E Park, MS Kim, K Ahn, IY Kim, EJ Choi 2000 J Biol Chem 275:2527
RW Johnstone, AA Ruefli, SW Lowe 2002 Cell 108:153
DR Green 2000 Cell 102:1
V Petronilli, P Costantini, L Scorrano, R Colonna, S Passamonti, P Bernardi 1994 J Biol Chem 269:16638
DY Cho, U Jung, AS Chung 1999 Biochem Mol Biol Int 47:781
Z Zhu, W Jiang, HE Ganther, C Ip, HJ Thompson 2000 Biochem Pharmacol 60:1467
MS Stewart, RL Davis, LP Walsh, BC Pence 1997 Cancer Lett 117:35
Z Zhu, M Kimura, Y Itokawa, T Aoki, JA Takahashi, S Nakatsu, Y Oda, H Kikuchi 1996 Biol Trace Elem Res 54:123
U Jung, X Zheng, SO Yoon, AS Chung 2001 Free Radic Biol Med 31:479
HM Shen, CF Yang, WX Ding, J Liu, CN Ong 2001 Free Radic Biol Med 30:9
C Jiang, KH Kim, Z Wang, J Lu 2004 Nutr Cancer 49:174
L Zuo, J Li, Y Yang, X Wang, T Shen, CM Xu, ZN Zhang 2004 Ann Hemato 183:751
M Takahashi, T Sato, F Shinohara, S Echigo, H Rikiishi 2005 Int J Onco 127:489
YW Chung, TS Kim, SY Lee, SH Lee, Y Choi, N Kim, BM Min, DW Jeong, IY Kim 2006 Toxicol Lett 160:143
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Kim, I.Y., Kim, T.S., Chung, Y.W., Jeong, D. (2006). Selenium-induced apoptosis. In: Hatfield, D.L., Berry, M.J., Gladyshev, V.N. (eds) Selenium. Springer, Boston, MA. https://doi.org/10.1007/0-387-33827-6_33
Download citation
DOI: https://doi.org/10.1007/0-387-33827-6_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-33826-2
Online ISBN: 978-0-387-33827-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)