Its Molecular Biology and Role in Human Health

  • Dolph L. Hatfield
  • Marla J. Berry
  • Vadim N. Gladyshev

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Selenium: A historical perspective

    1. James E. Oldfield
      Pages 1-6
  3. Biosynthesis of selenocysteine and its incorporation into protein

    1. Front Matter
      Pages 7-7
    2. August Böck, Michael Rother, Marc Leibundgut, Nenad Ban
      Pages 9-28
    3. Bradley A. Carlson, Xue-Ming Xu, Rajeev Shrimali, Aniruddha Sengupta, Min-Hyuk Yoo, Robert Irons et al.
      Pages 29-37
    4. Gustavo Salinas, Hétor Romero, Xue-Ming Xu, Bradley A. Carlson, Dolph L. Hatfield, Vadim N. Gladyshev
      Pages 39-50
    5. Donna M. Driscoll, Paul R. Copeland
      Pages 63-72
  4. Selenium-containing proteins

    1. Front Matter
      Pages 97-97
    2. Vadim N. Gladyshev
      Pages 99-110
    3. Raymond F. Burk, Gary E. Olson, Kristina E. Hill
      Pages 111-122
    4. Hwa-Young Kim, Vadim N. Gladyshev
      Pages 123-133
    5. Chrissa Kioussi, Philip D. Whanger
      Pages 135-140
    6. Vyacheslav M. Labunskyy, Vadim N. Gladyshev, Dolph L. Hatfield
      Pages 141-148
    7. Leopold Flohé, Regina Brigelius-Flohé
      Pages 161-172
    8. Arne Holmgren
      Pages 183-193

About this book


Selenium is an essential trace element in the diet of humans and many other life forms. As discussed in this book, selenium plays an important role in preventing certain forms of cancer, heart disease and other cardiovascular and muscle disorders. Evidence points to numerous other health benefits including an indispensable function in development, male reproduction and the immune system. In addition, selenium serves as an antiviral agent and may delay the onset of AIDS in HIV positive patients and delay the aging process. This element occurs primarily in cellular proteins in the form of a novel amino acid selenocysteine. Selenocysteine is the 21st amino acid in the genetic code and is cotranslationally incorporated into protein in response to the codon, UGA. Selenoproteins control redox homeostasis and are involved in variety of cellular pathways. The emphasis of this book is on the current status of the molecular biology of selenium. The importance of this element in human health is also highlighted.


AIDS Diabetes Evolution HIV Proteomics RNA Regulation biosynthesis cancer genes metabolism molecular biology prokaryotes proteins tRNA

Editors and affiliations

  • Dolph L. Hatfield
    • 1
  • Marla J. Berry
    • 2
  • Vadim N. Gladyshev
    • 3
  1. 1.National Cancer InstituteUSA
  2. 2.University of HawaiiUSA
  3. 3.Univeristy of NebraskaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-33826-2
  • Online ISBN 978-0-387-33827-9
  • About this book