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Selenoprotein W in development and oxidative stress

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Selenium

Summary

Dietary selenium deficiency in animals results in significant reduction of selenoprotein W (SEW) expression in their tissues. Selenium supplementation results in SeW accumulation predominantly in skeletal muscle and heart, suggesting a critical metabolic role for this protein in these tissues. SeW is expressed in the developing heart, muscle, brain, neural tube and otic ventricle during mouse development. SeW promoter studies indicated the presence of metal response element consensus sequences and binding sites for factors that suppress SeW expression. SeW exhibits glutathione-dependent redox properties in vivo. Aerobic growth conditions in microbes favor the production of SeW without the attached glutathione, whereas anaerobic growth conditions promote the glutathione-bound form. SeW levels are upregulated under oxidative stress in myoblasts. We suggest that SeW is a scavenger for reactive oxygen species such as hydrogen peroxide during muscle and nervous system development.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA

    Chrissa Kioussi

  2. Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA

    Philip D. Whanger

Authors
  1. Chrissa Kioussi
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  2. Philip D. Whanger
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Editor information

Editors and Affiliations

  1. National Cancer Institute, USA

    Dolph L. Hatfield

  2. University of Hawaii, USA

    Marla J. Berry

  3. Univeristy of Nebraska, USA

    Vadim N. Gladyshev

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© 2006 Springer Science+Business Media, LLC

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Kioussi, C., Whanger, P.D. (2006). Selenoprotein W in development and oxidative stress. In: Hatfield, D.L., Berry, M.J., Gladyshev, V.N. (eds) Selenium. Springer, Boston, MA. https://doi.org/10.1007/0-387-33827-6_12

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