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Polyomavirus in Human Cancer Development

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Polyomaviruses and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

In animal studies, polyoma viruses have been found to be viral agents for oncogenesis and to produce a wide range of pathological lesions in experimental animals, including a variety of neoplastic tumors. The human polyoma viruses (JCV and BKV), along with their simian cousin (SV40), are ubiquitous viruses that are primarily associated with progressive multifocal leukoencephalolopathy (PML) and hemorrhagic cystitis, respectively, under specific conditions in immunocompromized individuals. Currendy, polyoma viruses are now undergoing increasing scrutiny as possible causes for several human cancers. Evidence has been mounting recendy that JCV, BKV as well as SV40 are potential oncogenic viruses in humans as well.

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Authors and Affiliations

  1. Mount Sinai Medical School, New York, New York, USA

    Winston Lee M.D. & Erik Langhoff

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  1. Winston Lee M.D.
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  2. Erik Langhoff
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Editors and Affiliations

  1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, Florida, USA

    Nasimul Ahsan M.D., FACP

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Lee, W., Langhoff, E. (2006). Polyomavirus in Human Cancer Development. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_22

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